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Received today — 7 October 2026 ⏭ Nature Cancer

Nature Cancer
An iron-regulated methionine redox axis governs adipose browning and cancer cachexia Jung Seung Nam · Sung Shin Ahn · Yeonoh Shin · Ariana Vargas-Castillo · Maya S. Dixon · Pardis Ahmadi · Kathrin Schilling · Fereshteh Zandkarimi · Alex Chen · Nal Ae Yoon · Harrison Cullen · Yanping Sun · Thomas C. Caffrey · Kelsey A. Klute · Benjamin J. Swanson · Jordan Lu · Samuel Pan · Yuxuan Chen · Shu Ichimiya · Geena Kim · Jeanine M. Genkinger · Kazuki Sugahara · Michael D. Kluger · Paul Grandgenett · Michael A. Hollingsworth · Luke Berchowitz · Anthony W. Ferrante Jr. · Lori M. Zeltser · Sabrina Diano · Iok In Christine Chio
Nature Cancer, Published online: 22 September 2026; doi:10.1038/s43018-026-01234-yChio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide reductase A as an important and targetable factor in this process.
22 September 2026 at 08:00

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

By: Jung Seung Nam · Sung Shin Ahn · Yeonoh Shin · Ariana Vargas-Castillo · Maya S. Dixon · Pardis Ahmadi · Kathrin Schilling · Fereshteh Zandkarimi · Alex Chen · Nal Ae Yoon · Harrison Cullen · Yanping Sun · Thomas C. Caffrey · Kelsey A. Klute · Benjamin J. Swanson · Jordan Lu · Samuel Pan · Yuxuan Chen · Shu Ichimiya · Geena Kim · Jeanine M. Genkinger · Kazuki Sugahara · Michael D. Kluger · Paul Grandgenett · Michael A. Hollingsworth · Luke Berchowitz · Anthony W. Ferrante Jr. · Lori M. Zeltser · Sabrina Diano · Iok In Christine Chio

22 September 2026 at 08:00

Nature Cancer, Published online: 22 September 2026; doi:10.1038/s43018-026-01234-y

Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide reductase A as an important and targetable factor in this process.