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Received — 27 May 2026 ⏭ Nature Cancer

Nature Cancer
Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance Hui Tang · Ping Xie · Jihae Ahn · Mi-Ran Choi · Jie Fan · Siqi Chen · Yi Zhang · Bin Zhang
Nature Cancer, Published online: 19 May 2026; doi:10.1038/s43018-026-01174-7Tang et al. identify cysteinyl leukotriene receptor 1 (CysLTR1) as a critical regulator of tumor-induced myelopoiesis, suggesting CysLTR1 targeting to sensitize tumors to immune checkpoint blockade.
19 May 2026 at 08:00

Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance

By: Hui Tang · Ping Xie · Jihae Ahn · Mi-Ran Choi · Jie Fan · Siqi Chen · Yi Zhang · Bin Zhang

19 May 2026 at 08:00

Nature Cancer, Published online: 19 May 2026; doi:10.1038/s43018-026-01174-7

Tang et al. identify cysteinyl leukotriene receptor 1 (CysLTR1) as a critical regulator of tumor-induced myelopoiesis, suggesting CysLTR1 targeting to sensitize tumors to immune checkpoint blockade.