Nature Cancer, Published online: 14 September 2026; doi:10.1038/s43018-026-01235-xWe identified a metabolic signaling axis that enables pancreatic cancer cells to survive chemotherapy by suppressing ferroptosis. Targeting of the valine catabolism enzyme MMSDH reverses this chemoresistance and shows promise as a potential component of combination strategies against refractory tumors.

Nature Cancer, Published online: 14 September 2026; doi:10.1038/s43018-026-01237-9Marsoni et al. evaluated the feasibility of a dynamic circulating tumor DNA-guided adjuvant and postadjuvant treatment strategy in patients with resected microsatellite-stable, high-risk stage II or III colon cancer in the phase 2 PEGASUS trial.

Nature Cancer, Published online: 11 September 2026; doi:10.1038/s43018-026-01236-wZheng et al. describe how hypoxia-induced methylmalonate semialdehyde dehydrogenase lactylation promotes acyl-CoA synthetase long-chain family member 4 propionylation and degradation, thereby suppressing ferroptosis induced by chemotherapy, and develop a blocking peptide that increased chemotherapy efficacy in pancreatic ductal adenocarcinoma.