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Received β€” 5 March 2026 ⏭ cs.AI, q-bio.NC updates on arXiv.org

Performance of Conventional EEG Biomarkers Across Different Clinical Phases of Major Depressive Disorder: A Comprehensive Evaluation

arXiv:2603.03864v1 Announce Type: new Abstract: While EEG features differentiate Major Depressive Disorder (MDD) from healthy controls (HC), their clinical utility as biomarkers depends on a monotonic trajectory across the disease spectrum, from the acute (AC) phase to the maintenance (MA) phase and finally to the healthy baseline. However, the progression of the MA phase remains poorly understood in traditional marker analysis. Analyzing EEG data from 74 individuals (24 AC, 23 MA, and 27 HC), this study provides a comprehensive evaluation of classic ERP and resting-state indices across AC, MA, and HC groups. Our results demonstrate that almost no conventional metrics strictly satisfy the criterion of monotonic progression, likely due to profound inter-individual heterogeneity. These findings highlight the inherent limitations of group-level feature extraction and provide critical insights for developing future paradigms and algorithms to identify neurobiological markers with genuine clinical utility.
Received β€” 25 February 2026 ⏭ cs.AI, q-bio.NC updates on arXiv.org

Pushing the Limits of Inverse Lithography with Generative Reinforcement Learning

arXiv:2602.19027v1 Announce Type: cross Abstract: Inverse lithography (ILT) is critical for modern semiconductor manufacturing but suffers from highly non-convex objectives that often trap optimization in poor local minima. Generative AI has been explored to warm-start ILT, yet most approaches train deterministic image-to-image translators to mimic sub-optimal datasets, providing limited guidance for escaping non-convex traps during refinement. We reformulate mask synthesis as conditional sampling: a generator learns a distribution over masks conditioned on the design and proposes multiple candidates. The generator is first pretrained with WGAN plus a reconstruction loss, then fine-tuned using Group Relative Policy Optimization (GRPO) with an ILT-guided imitation loss. At inference, we sample a small batch of masks, run fast batched ILT refinement, evaluate lithography metrics (e.g., EPE, process window), and select the best candidate. On \texttt{LithoBench} dataset, the proposed hybrid framework reduces EPE violations under a 3\,nm tolerance and roughly doubles throughput versus a strong numerical ILT baseline, while improving final mask quality. We also present over 20\% EPE improvement on \texttt{ICCAD13} contest cases with 3$\times$ speedup over the SOTA numerical ILT solver. By learning to propose ILT-friendly initializations, our approach mitigates non-convexity and advances beyond what traditional solvers or GenAI can achieve.

MemOCR: Layout-Aware Visual Memory for Efficient Long-Horizon Reasoning

By: Yaorui Shi Β· Shugui Liu Β· Yu Yang Β· Wenyu Mao Β· Yuxin Chen Β· Qi GU Β· Hui Su Β· Xunliang Cai Β· Xiang Wang Β· An Zhang
24 February 2026 at 13:00
arXiv:2601.21468v3 Announce Type: replace Abstract: Long-horizon agentic reasoning necessitates effectively compressing growing interaction histories into a limited context window. Most existing memory systems serialize history as text, where token-level cost is uniform and scales linearly with length, often spending scarce budget on low-value details. To this end, we introduce MemOCR, a multimodal memory agent that improves long-horizon reasoning under tight context budgets by allocating memory space with adaptive information density through visual layout. Concretely, MemOCR maintains a structured rich-text memory (e.g., headings, highlights) and renders it into an image that the agent consults for memory access, visually prioritizing crucial evidence while aggressively compressing auxiliary details. To ensure robustness across varying memory budgets, we train MemOCR with reinforcement learning under budget-aware objectives that expose the agent to diverse compression levels. Across long-context multi-hop and single-hop question-answering benchmarks, MemOCR outperforms strong text-based baselines and achieves more effective context utilization under extreme budgets.

Lean Finder: Semantic Search for Mathlib That Understands User Intents

arXiv:2510.15940v2 Announce Type: replace-cross Abstract: We present Lean Finder, a semantic search engine for Lean and mathlib that understands and aligns with the intents of mathematicians. Progress in formal theorem proving is often hindered by the difficulty of locating relevant theorems and the steep learning curve of the Lean 4 language, making advancement slow and labor-intensive. Existing Lean search engines, though helpful, rely primarily on informalizations (natural language translation of the formal statements), while largely overlooking the mismatch with real-world user queries. In contrast, we propose a user-centered semantic search tailored to the needs of mathematicians. Our approach begins by analyzing and clustering the semantics of public Lean discussions, then fine-tuning text embeddings on synthesized queries that emulate user intents. We further align Lean Finder with mathematicians' preferences using diverse feedback signals, encoding it with a rich awareness of their goals from multiple perspectives. Evaluations on real-world queries, informalized statements, and proof states demonstrate that our Lean Finder achieves over $30\%$ relative improvement compared to previous search engines and GPT-4o. In addition, Lean Finder is compatible with LLM-based theorem provers, bridging retrieval with formal reasoning. Lean Finder is available at: https://leanfinder.github.io
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