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Received β€” 26 March 2026 ⏭ cs.AI, q-bio.NC updates on arXiv.org

Rethinking the Role of Entropy in Optimizing Tool-Use Behaviors for Large Language Model Agents

arXiv:2602.02050v3 Announce Type: replace Abstract: Tool-using agents based on Large Language Models (LLMs) excel in tasks such as mathematical reasoning and multi-hop question answering. However, in long trajectories, agents often trigger excessive and low-quality tool calls, increasing latency and degrading inference performance, making managing tool-use behavior challenging. In this work, we conduct entropy-based pilot experiments and observe a strong positive correlation between entropy reduction and high-quality tool calls. Building on this finding, we propose using entropy reduction as a supervisory signal and design two reward strategies to address the differing needs of optimizing tool-use behavior. Sparse outcome rewards provide coarse, trajectory-level guidance to improve efficiency, while dense process rewards offer fine-grained supervision to enhance performance. Experiments across diverse domains show that both reward designs improve tool-use behavior: the former reduces tool calls by 72.07% compared to the average of baselines, while the latter improves performance by 22.27%. These results position entropy reduction as a key mechanism for enhancing tool-use behavior, enabling agents to be more adaptive in real-world applications.

LoD-Loc v3: Generalized Aerial Localization in Dense Cities using Instance Silhouette Alignment

arXiv:2603.19609v2 Announce Type: replace-cross Abstract: We present LoD-Loc v3, a novel method for generalized aerial visual localization in dense urban environments. While prior work LoD-Loc v2 achieves localization through semantic building silhouette alignment with low-detail city models, it suffers from two key limitations: poor cross-scene generalization and frequent failure in dense building scenes. Our method addresses these challenges through two key innovations. First, we develop a new synthetic data generation pipeline that produces InsLoD-Loc - the largest instance segmentation dataset for aerial imagery to date, comprising 100k images with precise instance building annotations. This enables trained models to exhibit remarkable zero-shot generalization capability. Second, we reformulate the localization paradigm by shifting from semantic to instance silhouette alignment, which significantly reduces pose estimation ambiguity in dense scenes. Extensive experiments demonstrate that LoD-Loc v3 outperforms existing state-of-the-art (SOTA) baselines, achieving superior performance in both cross-scene and dense urban scenarios with a large margin. The project is available at https://nudt-sawlab.github.io/LoD-Locv3/.
Received β€” 25 February 2026 ⏭ cs.AI, q-bio.NC updates on arXiv.org

AI-driven Large-scale Electron Microscopy enables Whole-tissue Subcellular Digitization

By: Li Xiao Β· Liqing Liu Β· Hongjun Wu Β· Jiayi Zhong Β· Xixia Li Β· Yan Zhang Β· Junjie Hu Β· Sun Fei Β· Ge Yang Β· Tao Xu
24 February 2026 at 13:00
arXiv:2511.02860v2 Announce Type: replace-cross Abstract: The distribution and interactions of cellular organelles play a critical role in mediating cellular physiology and pathology. Large-scale electron microscopy enables visualization of organelle distribution and interactions at the tissue level with nanometer resolution, but robust and efficient computational analysis tools are lacking. Here, we present a deep learning tool for universal large-scale 2D/3D electron microscopy analysis, DeepOrganelle. This new tool enables high-throughput, cell-resolved spatiotemporal mapping and digitization of organelle distribution and interactions. When applied to spermatogenesis across 12 stages and 22 differentiation status of the germ cells, DeepOrganelle uncovered previously unrecognized, stage-dependent dynamics of mitochondria-endoplasmic reticulum contact sites within one subphase of prophase I during meiosis. It also revealed coordinated organelle redistribution in Sertoli cells towards the blood-testis barrier, digitizing the remodeling dynamics of the tissue. This study demonstrates that DeepOrganelle provides a powerful framework that captures subcellular dynamics at the whole-tissue level.
Received β€” 17 February 2026 ⏭ cs.AI, q-bio.NC updates on arXiv.org

PT-RAG: Structure-Fidelity Retrieval-Augmented Generation for Academic Papers

arXiv:2602.13647v1 Announce Type: cross Abstract: Retrieval-augmented generation (RAG) is increasingly applied to question-answering over long academic papers, where accurate evidence allocation under a fixed token budget is critical. Existing approaches typically flatten academic papers into unstructured chunks during preprocessing, which destroys the native hierarchical structure. This loss forces retrieval to operate in a disordered space, thereby producing fragmented contexts, misallocating tokens to non-evidential regions under finite token budgets, and increasing the reasoning burden for downstream language models. To address these issues, we propose PT-RAG, an RAG framework that treats the native hierarchical structure of academic papers as a low-entropy retrieval prior. PT-RAG first inherits the native hierarchy to construct a structure-fidelity PaperTree index, which prevents entropy increase at the source. It then designs a path-guided retrieval mechanism that aligns query semantics to relevant sections and selects high relevance root-to-leaf paths under a fixed token budget, yielding compact, coherent, and low-entropy retrieval contexts. In contrast to existing RAG approaches, PT-RAG avoids entropy increase caused by destructive preprocessing and provides a native low-entropy structural basis for subsequent retrieval. To assess this design, we introduce entropy-based structural diagnostics that quantify retrieval fragmentation and evidence allocation accuracy. On three academic question-answering benchmarks, PT-RAG achieves consistently lower section entropy and evidence alignment cross entropy than strong baselines, indicating reduced context fragmentation and more precise allocation to evidential regions. These structural advantages directly translate into higher answer quality.
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