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Received — 10 September 2026 ⏭ Nature Nanotechnology

Nature Nanotechnology
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles Dengpan Liang · Yalin Qi · Hesong Han · Negar Ahmadian · Kewa Gao · Kaycee Sapasap · Yuxi Zhang · Silin Guo · Atip Lawanprasert · Sopida Pimcharoen · Sheng Zhao · Milan T. Del Buono · He Xia · Zoe O. Enders · Benjamin W. Burgstone · Antonino Calio · Neel Dankar · Bingwei Lu · Lei S. Qi · Aijun Wang · Niren Murthy
Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02262-6Charge-switching S-lipids generate S-lipid nanoparticles that are neutral or negative at physiological pH but become cationic in acidic endosomes, enabling nucleic acid delivery with reduced inflammation compared with conventional LNPs.
8 September 2026 at 08:00

Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles

By: Dengpan Liang · Yalin Qi · Hesong Han · Negar Ahmadian · Kewa Gao · Kaycee Sapasap · Yuxi Zhang · Silin Guo · Atip Lawanprasert · Sopida Pimcharoen · Sheng Zhao · Milan T. Del Buono · He Xia · Zoe O. Enders · Benjamin W. Burgstone · Antonino Calio · Neel Dankar · Bingwei Lu · Lei S. Qi · Aijun Wang · Niren Murthy

8 September 2026 at 08:00

Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02262-6

Charge-switching S-lipids generate S-lipid nanoparticles that are neutral or negative at physiological pH but become cationic in acidic endosomes, enabling nucleic acid delivery with reduced inflammation compared with conventional LNPs.