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Received — 10 September 2026 ⏭ Nature Biomedical Engineering

Nature Biomedical Engineering
Engineered autophagy receptors administered with extracellular vesicles eliminate pathological Tau and TDP-43 Huishan Guo · Alexandre Savard · Charlotte Manser · Kallol Dutta · James A. Taylor · Maxime W. C. Rousseaux · Silvia Pozzi · Jean-Pierre Julien · Stephen Baird · Derrick Gibbings
Nature Biomedical Engineering, Published online: 26 August 2026; doi:10.1038/s41551-026-01774-9Autophagy receptors are engineered fusing LC3 to cytoplasm-stable antibody variants and are delivered via small extracellular vesicles or adeno-associated virus to eliminate pathological Tau and TDP-43 in animal disease models.
26 August 2026 at 08:00

Engineered autophagy receptors administered with extracellular vesicles eliminate pathological Tau and TDP-43

By: Huishan Guo · Alexandre Savard · Charlotte Manser · Kallol Dutta · James A. Taylor · Maxime W. C. Rousseaux · Silvia Pozzi · Jean-Pierre Julien · Stephen Baird · Derrick Gibbings

26 August 2026 at 08:00

Nature Biomedical Engineering, Published online: 26 August 2026; doi:10.1038/s41551-026-01774-9

Autophagy receptors are engineered fusing LC3 to cytoplasm-stable antibody variants and are delivered via small extracellular vesicles or adeno-associated virus to eliminate pathological Tau and TDP-43 in animal disease models.