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Received β€” 10 September 2026 ⏭ ACS Applied Nano Materials advanceAccess

Sialic Acid-Functionalized Iron-Based Metal–Organic Framework Nanoprobe for Tumor-Targeted Near-Infrared Fluorescence/Magnetic Resonance Imaging of Cervical Cancer

βœ‡ACS Applied Nano Materials advanceAccess
9 September 2026 at 01:00
Abstract
Accurate localization and delineation of cervical cancer lesions are essential for precise surgical planning. However, conventional magnetic resonance imaging (MRI) often provides insufficient molecular specificity for tumor delineation, whereas near-infrared fluorescence (NIRF) imaging is restricted by shallow tissue penetration. Herein, we developed a sialic acid (N-Acetylneuraminic acid, Neu5Ac)-functionalized nanoscale iron-based metal–organic framework (MOF) nanoprobe, NH2-MIL-101(Fe)/Neu5Ac/Cy7, for tumor-targeted NIRF/MR dual-modal imaging of cervical cancer. The nanoscale Fe-MOF framework provides intrinsic T2-weighted MR contrast and serves as a functional scaffold for PEG/Neu5Ac surface modification and Cy7 loading. In SiHa cells, the Neu5Ac-functionalized nanoprobe exhibited approximately 2.1-fold and 3.9-fold higher intracellular fluorescence than the non-Neu5Ac-modified counterpart at 8 and 12 h, respectively. Time-dependent in vivo NIRF imaging further identified 8 h postinjection as a suitable imaging time point. In SiHa tumor-bearing mice, NH2-MIL-101(Fe)/Neu5Ac/Cy7 showed enhanced tumor-associated accumulation compared with control probes, as evidenced by pronounced T2-weighted MR signal attenuation and a 4.36-fold higher ex vivo tumor fluorescence intensity than the non-Neu5Ac-modified counterpart. Collectively, this nanoscale dual-modal imaging platform combines MRI-based deep-tissue localization with NIRF imaging sensitivity, offering a promising strategy for cervical cancer lesion visualization and tumor-region delineation.
  • βœ‡ACS Applied Nano Materials advanceAccess
  • Nanostructured Zirconia-Based Aerogels for High-Temperature Thermal Insulation
    AbstractZirconia-based aerogels are lightweight, porous materials made up of interconnected zirconia nanoparticles, forming continuous three-dimensional nanoporous networks. Their high melting point, low density, high porosity, and low thermal conductivity make them promising candidates for high-temperature thermal insulation and protection in extreme environments such as spacecraft thermal protection systems, high-speed aircraft, and high-temperature industrial equipment. However, their nanosca
     
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Nanostructured Zirconia-Based Aerogels for High-Temperature Thermal Insulation

βœ‡ACS Applied Nano Materials advanceAccess
7 September 2026 at 13:01
Abstract
Zirconia-based aerogels are lightweight, porous materials made up of interconnected zirconia nanoparticles, forming continuous three-dimensional nanoporous networks. Their high melting point, low density, high porosity, and low thermal conductivity make them promising candidates for high-temperature thermal insulation and protection in extreme environments such as spacecraft thermal protection systems, high-speed aircraft, and high-temperature industrial equipment. However, their nanoscale frameworks become unstable at high temperatures. Processes such as nanoparticle sintering, grain coarsening, and temperature-driven phase changes can cause pore collapse, structural damage, and a reduced level of insulation. This Review evaluates zirconia-based aerogels from a failure-mechanism-guided, application-focused perspective. It highlights recent progress in fabrication techniques, nanoscale structural control, and thermal insulation performance with a focus on strategies that enhance phase stability and preserve nanopores. The text reviews strategies like heteroelement doping, structural control, surface and interface modifications, core–shell architectures, and fiber reinforcement, focusing on their impact on sintering resistance, phase evolution, mechanical properties, and heat transfer. It highlights challenges and future opportunities for developing thermally stable zirconia-based aerogels for extreme-environment thermal protection.
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