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Rare variant associations with plasma protein levels in the UK Biobank

Nature, Published online: 04 October 2023; doi:10.1038/s41586-023-06547-x

A set of three papers in Nature reports a new proteomics resource from the UK Biobank and initial analysis of common and rare genetic variant associations with plasma protein levels.

Plasma proteomic associations with genetics and health in the UK Biobank

Nature, Published online: 04 October 2023; doi:10.1038/s41586-023-06592-6

The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor interactions and pathway perturbations across a diverse collection of cytokines and complement networks.
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