Characterization of microbiome genomes at the species level in over 4,000 metastatic tumor biopsies identifies the distribution and diversity features of tumor-resident bacterial DNA at a pan-cancer scale, highlighting the associations between microbial community dynamics and tumor immunity and immunotherapy efficacy.

Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06054-zThe genomic differences between primary and metastatic tumours are assessed across 23 cancer types using pan-cancer whole-genome analysis.