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IoT-LLM: a framework for enhancing Large Language Model reasoning from real-world sensor data

arXiv:2410.02429v4 Announce Type: replace Abstract: Large Language Models excel in textual tasks but often struggle with physical-world reasoning tasks. Inspired by human cognition, where perception is fundamental to reasoning, we explore augmenting LLMs with enhanced perception abilities using Internet of Things (IoT) data and pertinent knowledge. In this work, we systematically study LLMs' capability to address IoT-sensory tasks by augmenting their perception and knowledge base, and then propose a unified framework, IoT-LLM, to enhance such capability. In IoT-LLM, we customize three steps: preprocessing IoT data into suitable formats, expanding LLMs knowledge via IoT-oriented retrieval-augmented generation and activating LLMs commonsense knowledge through chain-of-thought prompting. We design a benchmark comprising five real-world tasks with varying data types and reasoning complexities to evaluate the performance of IoT-LLM. Experimental results reveal that IoT-LLM significantly improves the performance of IoT-sensory task reasoning of LLMs, with models like GPT-4o-mini showing a 49.4% average improvement over previous methods.

KnowMol: Advancing Molecular Large Language Models with Multi-Level Chemical Knowledge

arXiv:2510.19484v1 Announce Type: cross Abstract: The molecular large language models have garnered widespread attention due to their promising potential on molecular applications. However, current molecular large language models face significant limitations in understanding molecules due to inadequate textual descriptions and suboptimal molecular representation strategies during pretraining. To address these challenges, we introduce KnowMol-100K, a large-scale dataset with 100K fine-grained molecular annotations across multiple levels, bridging the gap between molecules and textual descriptions. Additionally, we propose chemically-informative molecular representation, effectively addressing limitations in existing molecular representation strategies. Building upon these innovations, we develop KnowMol, a state-of-the-art multi-modal molecular large language model. Extensive experiments demonstrate that KnowMol achieves superior performance across molecular understanding and generation tasks. GitHub: https://github.com/yzf-code/KnowMol Huggingface: https://hf.co/datasets/yzf1102/KnowMol-100K

Integrative spatial analysis reveals tumor heterogeneity and immune colony niche related to clinical outcomes in small cell lung cancer

Cancer Cell. 2025 Feb 14:S1535-6108(25)00030-3. doi: 10.1016/j.ccell.2025.01.012. Online ahead of print.

ABSTRACT

Recent advances have shed light on the molecular heterogeneity of small cell lung cancer (SCLC), yet the spatial organizations and cellular interactions in tumor immune microenvironment remain to be elucidated. Here, we employ co-detection by indexing (CODEX) and multi-omics profiling to delineate the spatial landscape for 165 SCLC patients, generating 267 high-dimensional images encompassing over 9.3 million cells. Integrating CODEX and genomic data reveals a multi-positive tumor cell neighborhood within ASCL1+ (SCLC-A) subtype, characterized by high SLFN11 expression and associated with poor prognosis. We further develop a cell colony detection algorithm (ColonyMap) and reveal a spatially assembled immune niche consisting of antitumoral macrophages, CD8+ T cells and natural killer T cells (MT2) which highly correlates with superior survival and predicts improving immunotherapy response in an independent cohort. This study serves as a valuable resource to study SCLC spatial heterogeneity and offers insights into potential patient stratification and personalized treatments.

PMID:39983726 | DOI:10.1016/j.ccell.2025.01.012

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

Nature, Published online: 05 October 2022; doi:10.1038/s41586-022-05169-z

Cleaved and intact type I collagen have different effects on pancreatic ductal adenocarcinoma (PDAC), and remodelling of type I collagen—mediated through DDR1 signalling—is a prognostic indicator for the survival of patients with PDAC.
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