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cs.AI, q-bio.NC updates on arXiv.org
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From User Interface to Agent Interface: Efficiency Optimization of UI Representations for LLM Agents
arXiv:2512.13438v1 Announce Type: cross Abstract: While Large Language Model (LLM) agents show great potential for automated UI navigation such as automated UI testing and AI assistants, their efficiency has been largely overlooked. Our motivating study reveals that inefficient UI representation creates a critical performance bottleneck. However, UI representation optimization, formulated as the task of automatically generating programs that transform UI representations, faces two unique challe
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(Multiomics OR Omics) AND (Pancreatic)
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Efficient discovery of robust prognostic biomarkers and signatures in solid tumors
Cancer Lett. 2025 Mar 31;613:217502. doi: 10.1016/j.canlet.2025.217502. Epub 2025 Jan 24.ABSTRACTRecent advancements in multi-omics and big-data technologies have facilitated the discovery of numerous cancer prognostic biomarkers and gene signatures. However, their clinical application remains limited due to poor reproducibility and insufficient independent validation. Despite the availability of high-quality datasets, achieving reliable biomarker identification across multiple cohorts continues
Efficient discovery of robust prognostic biomarkers and signatures in solid tumors
Cancer Lett. 2025 Mar 31;613:217502. doi: 10.1016/j.canlet.2025.217502. Epub 2025 Jan 24.
ABSTRACT
Recent advancements in multi-omics and big-data technologies have facilitated the discovery of numerous cancer prognostic biomarkers and gene signatures. However, their clinical application remains limited due to poor reproducibility and insufficient independent validation. Despite the availability of high-quality datasets, achieving reliable biomarker identification across multiple cohorts continues to be a significant challenge. To address these issues, we developed a comprehensive platform, SurvivalML, designed to support the discovery and validation of prognostic biomarkers and gene signatures using large-scale and harmonized data from 21 cancer types. Through SurvivalML, we identified DCLRE1B as a novel prognostic biomarker for hepatocellular carcinoma, with experimental confirmation of its role in promoting tumor progression. Additionally, we developed the Chinese glioblastoma prognostic signature (CGPS) and its simplified version, SCGPS, a three-gene model. Both demonstrated superior predictive performance compared to other glioblastoma signatures in our in-house cohort and five independent Chinese datasets. The SCGPS model was further validated in 109 clinical samples using multiplex immunofluorescence, showing strong consistency with the original CGPS model. Overall, SurvivalML provides a robust platform for the identification and validation of prognostic biomarkers and gene signatures, offering a valuable resource for advancing cancer research and clinical application.
PMID:39864538 | DOI:10.1016/j.canlet.2025.217502