Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
Benchmarking Egocentric Clinical Intent Understanding Capability for Medical Multimodal Large Language Models
arXiv:2601.06750v1 Announce Type: cross Abstract: Medical Multimodal Large Language Models (Med-MLLMs) require egocentric clinical intent understanding for real-world deployment, yet existing benchmarks fail to evaluate this critical capability. To address these challenges, we introduce MedGaze-Bench, the first benchmark leveraging clinician gaze as a Cognitive Cursor to assess intent understanding across surgery, emergency simulation, and diagnostic interpretation. Our benchmark addresses thre
-
cs.AI, q-bio.NC updates on arXiv.org
-
SciEvalKit: An Open-source Evaluation Toolkit for Scientific General Intelligence
arXiv:2512.22334v1 Announce Type: new Abstract: We introduce SciEvalKit, a unified benchmarking toolkit designed to evaluate AI models for science across a broad range of scientific disciplines and task capabilities. Unlike general-purpose evaluation platforms, SciEvalKit focuses on the core competencies of scientific intelligence, including Scientific Multimodal Perception, Scientific Multimodal Reasoning, Scientific Multimodal Understanding, Scientific Symbolic Reasoning, Scientific Code Gene
SciEvalKit: An Open-source Evaluation Toolkit for Scientific General Intelligence
-
(Multiomics OR Omics) AND (Pancreatic)
-
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma
Cell Death Dis. 2025 May 15;16(1):382. doi: 10.1038/s41419-025-07720-y.ABSTRACTM2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment (TME) drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to clarify the regulatory impacts of tumor-derived exosomes to TAMs. After the intratumoral injection to subcutaneous
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma
Cell Death Dis. 2025 May 15;16(1):382. doi: 10.1038/s41419-025-07720-y.
ABSTRACT
M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment (TME) drive their formation, the role of PDAC-derived exosomes in this process remains unclear. We aim to clarify the regulatory impacts of tumor-derived exosomes to TAMs. After the intratumoral injection to subcutaneous tumor of C57BL/6 mice, we demonstrated PDAC-derived exosomes exacerbate PDAC progression, accompanied with upregulated M2 phenotype of TAMs and unaffected proliferation signatures. Through intratumoral injection model and multi-Omics analyses, we identified CCT6A as a novel tumor-derived exosomal protein, bridging TAMs M2 polarization and PDAC prognosis. Co-culture with exosomes derived from CCT6Ahigh PDAC leads to greater M2 phenotype of TAMs via PI3K-AKT signaling. According to proteomics data, chemokines' abundance reduces over tenfold once exosomal CCT6A absence, including CXCL1, CXCL3, CCL20 and CCL5, whose interaction with CCT6A in PDAC cells was confirmed by interactomics data. Moreover, we found silencing CCT6A abrogated the antagonism effects of CD47 antibody immunotherapy. Our findings implied that the subunit of the T-complex protein Ring Complex (TRiC) CCT6A serves as a matchmaker during exosome-mediated chemokines transfer from PDAC to TAMs. Silencing CCT6A effectively sensitized PDAC to CD47 antibody immunotherapy in vivo.
PMID:40374617 | PMC:PMC12081750 | DOI:10.1038/s41419-025-07720-y
-
Cell Death Discovery nature.com science feeds
-
The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity
Cell Death Discovery, Published online: 03 July 2024; doi:10.1038/s41420-024-02075-3The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity
The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity
Cell Death Discovery, Published online: 03 July 2024; doi:10.1038/s41420-024-02075-3
The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity