Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
Multi-Agent Intelligence for Multidisciplinary Decision-Making in Gastrointestinal Oncology
arXiv:2512.08674v1 Announce Type: new Abstract: Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal Large Language Models (MLLMs), they frequently encounter challenges such as context dilution and hallucination when confronted with intricate, heterogeneous medical histories. In order to address these limitati
-
Omics In Lung
-
Extended Insights Into Advancing Multi-Omics and Prognostic Methods for Cancer Prognosis Forecasting
Front Biosci (Landmark Ed). 2025 Aug 30;30(8):44091. doi: 10.31083/FBL44091.ABSTRACTZhang et al.'s recent article utilizes comprehensive single-cell data to identify differences in tumor cell populations, highlighting the CKS1B+ malignant cell subcluster as a potential target for immunotherapy. It develops a prognostic and immunotherapeutic signature (PIS) based on this subcluster, demonstrating good performance in predicting lung adenocarcinoma (LUAD) prognosis. The study also validates the rol
Extended Insights Into Advancing Multi-Omics and Prognostic Methods for Cancer Prognosis Forecasting
Front Biosci (Landmark Ed). 2025 Aug 30;30(8):44091. doi: 10.31083/FBL44091.
ABSTRACT
Zhang et al.'s recent article utilizes comprehensive single-cell data to identify differences in tumor cell populations, highlighting the CKS1B+ malignant cell subcluster as a potential target for immunotherapy. It develops a prognostic and immunotherapeutic signature (PIS) based on this subcluster, demonstrating good performance in predicting lung adenocarcinoma (LUAD) prognosis. The study also validates the role of PSMB7 in LUAD progression. However, there are areas for improvement. There is a lack of clarity regarding the relationship between the CKS1B+ malignant cell subcluster and the PIS, particularly in terms of why PSMB7 was selected for functional studies. The sequencing data are retrospectively obtained from public databases and lack prospective clinical validation. It is suggested to collect LUAD patient tissues for RT-qPCR and RNA-seq analysis and seek external multi-center validations. Additionally, integrating emerging multi-omics methods is recommended to further validate the findings. Despite these limitations, the study represents progress in understanding LUAD and treatment strategies, and continuous evaluation and refinement of multi-omics and machine learning methods are expected for future research and clinical practice.
PMID:40917070 | DOI:10.31083/FBL44091