Normal view

Received — 10 February 2026 ⏭ Favourites

Cell
EcDNA-borne structural variants drive oncogenic fusion transcript amplification Hyerim Yi · Shu Zhang · Jason Swinderman · Yanbo Wang · Vishnupriya Kanakaveti · King L. Hung · Ivy Tsz-Lo Wong · Suhas Srinivasan · Ellis J. Curtis · Aarohi Bhargava-Shah · Rui Li · Matthew G. Jones · Jens Luebeck · Chris Bailey · Yanding Zhao · Julia A. Belk · Katerina Kraft · Quanming Shi · Xiaowei Yan · Simon K. Pritchard · Kabir S. Mahajan · Frances Liang · Mariam Jamal-Hanjani · Dean W. Felsher · Luke A. Gilbert · Vineet Bafna · Paul S. Mischel · Howard Y. Chang
Extrachromosomal DNA (ecDNA) is a major source of oncogenic fusions across cancer types, generating tissue-specific fusion landscapes with diagnostic potential. EcDNA-borne PVT1 5′-end fusions stabilize partner RNAs and boost oncogene output.
7 January 2026 at 08:00

EcDNA-borne structural variants drive oncogenic fusion transcript amplification

Cell

By: Hyerim Yi · Shu Zhang · Jason Swinderman · Yanbo Wang · Vishnupriya Kanakaveti · King L. Hung · Ivy Tsz-Lo Wong · Suhas Srinivasan · Ellis J. Curtis · Aarohi Bhargava-Shah · Rui Li · Matthew G. Jones · Jens Luebeck · Chris Bailey · Yanding Zhao · Julia A. Belk · Katerina Kraft · Quanming Shi · Xiaowei Yan · Simon K. Pritchard · Kabir S. Mahajan · Frances Liang · Mariam Jamal-Hanjani · Dean W. Felsher · Luke A. Gilbert · Vineet Bafna · Paul S. Mischel · Howard Y. Chang

7 January 2026 at 08:00

Extrachromosomal DNA (ecDNA) is a major source of oncogenic fusions across cancer types, generating tissue-specific fusion landscapes with diagnostic potential. EcDNA-borne PVT1 5′-end fusions stabilize partner RNAs and boost oncogene output.