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cs.AI, q-bio.NC updates on arXiv.org
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Tongyi DeepResearch Technical Report
arXiv:2510.24701v1 Announce Type: cross Abstract: We present Tongyi DeepResearch, an agentic large language model, which is specifically designed for long-horizon, deep information-seeking research tasks. To incentivize autonomous deep research agency, Tongyi DeepResearch is developed through an end-to-end training framework that combines agentic mid-training and agentic post-training, enabling scalable reasoning and information seeking across complex tasks. We design a highly scalable data syn
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Deep learning and inflammatory markers predict early response to immunotherapy in unresectable NSCLC: A multicenter study
Biomol Biomed. 2025 Jun 10. doi: 10.17305/bb.2025.12324. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICIs) demonstrate substantial interpatient variability in clinical efficacy for unresectable non-small cell lung cancer (NSCLC), underscoring the unmet need for noninvasive biomarkers to predict early therapeutic responses and improve survival outcomes. To address this, we developed a CT-based deep learning model integrated with the systemic immune-inflammatory-nutritional index (
Deep learning and inflammatory markers predict early response to immunotherapy in unresectable NSCLC: A multicenter study
Biomol Biomed. 2025 Jun 10. doi: 10.17305/bb.2025.12324. Online ahead of print.
ABSTRACT
Immune checkpoint inhibitors (ICIs) demonstrate substantial interpatient variability in clinical efficacy for unresectable non-small cell lung cancer (NSCLC), underscoring the unmet need for noninvasive biomarkers to predict early therapeutic responses and improve survival outcomes. To address this, we developed a CT-based deep learning model integrated with the systemic immune-inflammatory-nutritional index (SIINI) for early prediction of ICI response. In a retrospective multicenter study of 265 patients treated with ICIs (incorporating chest CT and laboratory data), the cohort was divided into training (70%), internal validation (30%), and external validation sets. The combined model-leveraging DenseNet121-derived deep radiomic features alongside SIINI-achieved strong predictive performance, with AUCs of 0.865 (95% CI: 0.7709-0.9595) in the internal validation cohort and 0.823 (95% CI: 0.6627-0.9827) in the external validation cohort. Gradient-weighted class activation mapping (Grad-CAM) highlighted key CT regions contributing to model predictions, enhancing interpretability for clinical application. These findings highlight the potential of integrating deep learning with inflammatory biomarkers to support personalized ICI therapy in unresectable NSCLC. Future directions include incorporating multi-omics biomarkers, expanding multicenter validation, and increasing sample sizes to further improve predictive accuracy and facilitate clinical translation.
PMID:40525631 | DOI:10.17305/bb.2025.12324
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Nature - Issue - nature.com science feeds
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7-Dehydrocholesterol dictates ferroptosis sensitivity
Nature, Published online: 31 January 2024; doi:10.1038/s41586-023-06983-97-Dehydrocholesterol (7-DHC) is a natural anti-ferroptotic metabolite and pharmacological manipulation of 7-DHC levels shows promise as a therapeutic strategy for cancer and ischaemia–reperfusion injury.
7-Dehydrocholesterol dictates ferroptosis sensitivity
Nature, Published online: 31 January 2024; doi:10.1038/s41586-023-06983-9
7-Dehydrocholesterol (7-DHC) is a natural anti-ferroptotic metabolite and pharmacological manipulation of 7-DHC levels shows promise as a therapeutic strategy for cancer and ischaemia–reperfusion injury.-
Most Recent Articles: Clinical Epigenetics
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Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer
To explore the possible carcinogenesis and help better diagnose and treat patients with synchronous multiple primary lung cancers (sMPLC), we systematically investigated the genetic and DNA methylation profile...