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cs.AI, q-bio.NC updates on arXiv.org
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BEDI: A Comprehensive Benchmark for Evaluating Embodied Agents on UAVs
arXiv:2505.18229v2 Announce Type: replace-cross Abstract: With the rapid advancement of low-altitude remote sensing and Vision-Language Models (VLMs), Embodied Agents based on Unmanned Aerial Vehicles (UAVs) have shown significant potential in autonomous tasks. However, current evaluation methods for UAV-Embodied Agents (UAV-EAs) remain constrained by the lack of standardized benchmarks, diverse testing scenarios and open system interfaces. To address these challenges, we propose BEDI (Benchmar
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(Multiomics OR Omics) AND (Pancreatic)
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Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer
iScience. 2025 May 15;28(6):112681. doi: 10.1016/j.isci.2025.112681. eCollection 2025 Jun 20.ABSTRACTMetabolic reprogramming is a defining feature of pancreatic cancer, influencing tumor progression and the tumor microenvironment. By integrating single-cell transcriptomics, spatial transcriptomics, and spatial metabolomics, this study visualized the spatial co-localization of metabolites and gene expression within tumor samples, uncovering metabolic heterogeneity and intercellular interactions.
Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer
iScience. 2025 May 15;28(6):112681. doi: 10.1016/j.isci.2025.112681. eCollection 2025 Jun 20.
ABSTRACT
Metabolic reprogramming is a defining feature of pancreatic cancer, influencing tumor progression and the tumor microenvironment. By integrating single-cell transcriptomics, spatial transcriptomics, and spatial metabolomics, this study visualized the spatial co-localization of metabolites and gene expression within tumor samples, uncovering metabolic heterogeneity and intercellular interactions. Spatial transcriptomics identified distinct pathological regions, which were further characterized using single-cell transcriptomic data and pathologist annotations. Pseudotime trajectory analysis revealed metabolic shifts along the malignant progression, while single-cell Metabolism (scMetabolism) delineated metabolic differences between pathological regions, classifying them as hypermetabolic or hypometabolic. Notably, aberrant cell communication between cancer cells, macrophages, and fibroblasts was observed, with key receptor-ligand pairs significantly co-expressed in malignant regions and correlated with poor prognosis. Spatial metabolomics imaging identified signature metabolites, highlighting metabolic alterations in amino acid metabolism, polyamine metabolism, fatty acid synthesis, and phospholipid metabolism. This integrated analysis provides critical insights into pancreatic cancer metabolism, offering potential avenues for targeted therapeutic interventions.
PMID:40538442 | PMC:PMC12177182 | DOI:10.1016/j.isci.2025.112681