Normal view

Received — 24 December 2024 ⏭ Favourites

Nature - Issue - nature.com science feeds
Reprogramming tumour-associated macrophages to outcompete cancer cells Xian Zhang · Shun Li · Isha Malik · Mytrang H. Do · Liangliang Ji · Chun Chou · Wei Shi · Kristelle J. Capistrano · Jing Zhang · Ting-Wei Hsu · Briana G. Nixon · Ke Xu · Xinxin Wang · Andrea Ballabio · Laura S. Schmidt · W. Marston Linehan · Ming O. Li
Nature, Published online: 28 June 2023; doi:10.1038/s41586-023-06256-5In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1 signalling in MYC-overexpressing cancer cells through cell competition, serving as an innate immune defence mechanism to slow tumour growth.
28 June 2023 at 08:00

Reprogramming tumour-associated macrophages to outcompete cancer cells

Nature - Issue - nature.com science feeds

By: Xian Zhang · Shun Li · Isha Malik · Mytrang H. Do · Liangliang Ji · Chun Chou · Wei Shi · Kristelle J. Capistrano · Jing Zhang · Ting-Wei Hsu · Briana G. Nixon · Ke Xu · Xinxin Wang · Andrea Ballabio · Laura S. Schmidt · W. Marston Linehan · Ming O. Li

28 June 2023 at 08:00

Nature, Published online: 28 June 2023; doi:10.1038/s41586-023-06256-5

In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1 signalling in MYC-overexpressing cancer cells through cell competition, serving as an innate immune defence mechanism to slow tumour growth.