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Whole-genome sequencing of 490,640 UK Biobank participants

Nature, Published online: 06 August 2025; doi:10.1038/s41586-025-09272-9

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Large-scale plasma proteomics comparisons through genetics and disease associations

Nature, Published online: 04 October 2023; doi:10.1038/s41586-023-06563-x

Comparisons of phenotypic and genetic association with protein levels from Icelandic and UK Biobank cohorts show that using multiple analysis platforms and stratifying populations by ancestry improves the detection of associations and allows the refinement of their location within the genome.
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