Nature Biotechnology, Published online: 06 November 2025; doi:10.1038/s41587-025-02895-3Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.

Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision outlines their design and collaborative development, promising to transform biological research through high-fidelity simulations, accelerating discoveries, and fostering interdisciplinary open science collaborations.

Nature, Published online: 26 June 2024; doi:10.1038/s41586-024-07552-4A bispecific non-coding RNA expressed by the IS110 family of mobile genetic elements forms the basis of a programmable genome-editing system that enables the insertion, excision or inversion of specific target DNA sequences.