Nature, Published online: 02 July 2025; doi:10.1038/s41586-025-09096-7The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Single-cell datasets are increasing in number and size. To leverage this rich resource, new workflows can reveal novel insights and discoveries. This perspective discusses the computational challenges and opportunities for single-cell reference-mapping algorithms that may eventually replace manual and laborious unsupervised clustering pipelines.

Nature Biotechnology, Published online: 25 May 2023; doi:10.1038/s41587-023-01767-yReference mapping is extended beyond scRNA-seq to single-cell epigenetic and proteomic data.

Nature Biotechnology, Published online: 19 December 2022; doi:10.1038/s41587-022-01588-5Cell surface protein expression and multiple epigenetic features are mapped simultaneously in single cells.