Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome
5 October 2022 at 08:00
Nature, Published online: 05 October 2022; doi:10.1038/s41586-022-05169-z
Cleaved and intact type I collagen have different effects on pancreatic ductal adenocarcinoma (PDAC), and remodelling of type I collagen—mediated through DDR1 signalling—is a prognostic indicator for the survival of patients with PDAC.