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A Goal-Driven Survey on Root Cause Analysis

arXiv:2510.19593v1 Announce Type: cross Abstract: Root Cause Analysis (RCA) is a crucial aspect of incident management in large-scale cloud services. While the term root cause analysis or RCA has been widely used, different studies formulate the task differently. This is because the term "RCA" implicitly covers tasks with distinct underlying goals. For instance, the goal of localizing a faulty service for rapid triage is fundamentally different from identifying a specific functional bug for a definitive fix. However, previous surveys have largely overlooked these goal-based distinctions, conventionally categorizing papers by input data types (e.g., metric-based vs. trace-based methods). This leads to the grouping of works with disparate objectives, thereby obscuring the true progress and gaps in the field. Meanwhile, the typical audience of an RCA survey is either laymen who want to know the goals and big picture of the task or RCA researchers who want to figure out past research under the same task formulation. Thus, an RCA survey that organizes the related papers according to their goals is in high demand. To this end, this paper presents a goal-driven framework that effectively categorizes and integrates 135 papers on RCA in the context of cloud incident management based on their diverse goals, spanning the period from 2014 to 2025. In addition to the goal-driven categorization, it discusses the ultimate goal of all RCA papers as an umbrella covering different RCA formulations. Moreover, the paper discusses open challenges and future directions in RCA.

Early Screening and Subtype Identification of High-Risk Lung Nodules via Breathprint by Graphene eNose Platform: A Large Cohort Study

ACS Sens. 2025 Apr 25;10(4):3101-3111. doi: 10.1021/acssensors.5c00314. Epub 2025 Apr 7.

ABSTRACT

Early screening of individuals with high-risk lung nodules can significantly improve the prognosis of lung cancer patients, and accurate identification of lung nodule subtypes can provide guidance for medical treatment. Exhaled breath (EB) analysis via eNoses offers a quick and noninvasive approach, but current eNose technology lacks quality control and solid validation in large population studies. Herein, an eNose platform integrated with a metal ion-decorated graphene sensor array and a breath sampling accessory was established. EB samples from 427 healthy subjects and 2586 subjects with lung nodules, including various benign and malignant subtypes, were collected through the breath sampling accessory for quality control. The large-cohort clinical EB samples were analyzed by the eNose platform to acquire the cross-reactive resistance response. Breathprint analysis for high-risk lung nodules using SVM and age-matched training sets yielded strong and robust performance. Combined with baseline data, the model achieved an AUC of 0.93 (95% CI, 0.89-0.96) on the external test set, with 97% sensitivity and 73% specificity. Moreover, dimensionality reduction analysis of breathprints demonstrated separability across different lung nodule subtypes. This study demonstrates the reliability of the graphene eNose platform to identify high-risk lung nodules and classify lung nodule subtypes in a noninvasive and rapid method.

PMID:40193324 | DOI:10.1021/acssensors.5c00314

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