Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09478-xDNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription interact to shape cell identity and tissue development.

Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.