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Received — 24 December 2024 ⏭ Favourites

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

✇Nature - Issue - nature.com science feeds
By: Hengxing Chen · Yun Li · Huafu Li · Xiancong Chen · Huafeng Fu · Deli Mao · Wei Chen · Linxiang Lan · Chunming Wang · Kaishun Hu · Jia Li · Chengming Zhu · Ian Evans · Eddie Cheung · Daning Lu · Yulong He · Axel Behrens · Dong Yin · Changhua Zhang
3 July 2024 at 08:00

Nature, Published online: 03 July 2024; doi:10.1038/s41586-024-07620-9

Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.

Detection of ovarian cancer using plasma cell-free DNA methylomes

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By: Huaiwu Lu， Yunyun Liu， Jingyu Wang， Shaliu Fu， Lingping Wang， Chunxian Huang， Jing Li， Lingling Xie， Dongyan Wang， Dan Li， Hui Zhou and Qunxian Rao
9 June 2022 at 08:00
Ovarian cancer (OC) is a highly lethal gynecologic cancer, and it is hard to diagnose at an early stage. Clinically, there are no ovarian cancer-specific markers for early detection. Here, we demonstrate the u...
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