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Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA

Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by noninvasive liquid biopsy. However, traditional methylation analysis meth...

Spatial genomics maps the structure, nature and evolution of cancer clones

Nature, Published online: 09 November 2022; doi:10.1038/s41586-022-05425-2

A workflow centred around base-specific in situ sequencing generates detailed maps of, and can phenotypically characterize, the unique set of subclones of cancers.
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