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Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations

Complex disorders require precise strategies for their characterization. AI-based digital phenotypes from biosensors can be used to predict psychiatric disorders and identify GWAS loci.

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1

The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.
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