Signal transduction plays a pivotal role in modulating a myriad of critical processes, including the tumour microenvironment (TME), cell cycle arrest, proliferation and apoptosis of tumour cells, as well as th...

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08636-5Systems-level Worm Perturb-Seq of metabolic genes reveals design principles of transcriptional metabolic rewiring, many of which can be explained by a compensation–repression model.

Nature, Published online: 14 February 2024; doi:10.1038/s41586-024-07054-3The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.