Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
BLM$_1$: A Boundless Large Model for Cross-Space, Cross-Task, and Cross-Embodiment Learning
arXiv:2510.24161v1 Announce Type: new Abstract: Multimodal large language models (MLLMs) have advanced vision-language reasoning and are increasingly deployed in embodied agents. However, significant limitations remain: MLLMs generalize poorly across digital-physical spaces and embodiments; vision-language-action models (VLAs) produce low-level actions yet lack robust high-level embodied reasoning; and most embodied large language models (ELLMs) are constrained to digital-space with poor genera
-
cs.AI, q-bio.NC updates on arXiv.org
-
From Cross-Task Examples to In-Task Prompts: A Graph-Based Pseudo-Labeling Framework for In-context Learning
arXiv:2510.24528v1 Announce Type: new Abstract: The capability of in-context learning (ICL) enables large language models (LLMs) to perform novel tasks without parameter updates by conditioning on a few input-output examples. However, collecting high-quality examples for new or challenging tasks can be costly and labor-intensive. In this work, we propose a cost-efficient two-stage pipeline that reduces reliance on LLMs for data labeling. Our approach first leverages readily available cross-task
From Cross-Task Examples to In-Task Prompts: A Graph-Based Pseudo-Labeling Framework for In-context Learning
-
cs.AI, q-bio.NC updates on arXiv.org
-
Generative AI for Healthcare: Fundamentals, Challenges, and Perspectives
arXiv:2510.24551v1 Announce Type: new Abstract: Generative Artificial Intelligence (GenAI) is taking the world by storm. It promises transformative opportunities for advancing and disrupting existing practices, including healthcare. From large language models (LLMs) for clinical note synthesis and conversational assistance to multimodal systems that integrate medical imaging, electronic health records, and genomic data for decision support, GenAI is transforming the practice of medicine and the
Generative AI for Healthcare: Fundamentals, Challenges, and Perspectives
-
cs.AI, q-bio.NC updates on arXiv.org
-
Genotype-Phenotype Integration through Machine Learning and Personalized Gene Regulatory Networks for Cancer Metastasis Prediction
arXiv:2510.23620v1 Announce Type: cross Abstract: Metastasis is the leading cause of cancer-related mortality, yet most predictive models rely on shallow architectures and neglect patient-specific regulatory mechanisms. Here, we integrate classical machine learning and deep learning to predict metastatic potential across multiple cancer types. Gene expression profiles from the Cancer Cell Line Encyclopedia were combined with a transcription factor-target prior from DoRothEA, focusing on nine me
Genotype-Phenotype Integration through Machine Learning and Personalized Gene Regulatory Networks for Cancer Metastasis Prediction
-
cs.AI, q-bio.NC updates on arXiv.org
-
Integrating Genomics into Multimodal EHR Foundation Models
arXiv:2510.23639v1 Announce Type: cross Abstract: This paper introduces an innovative Electronic Health Record (EHR) foundation model that integrates Polygenic Risk Scores (PRS) as a foundational data modality, moving beyond traditional EHR-only approaches to build more holistic health profiles. Leveraging the extensive and diverse data from the All of Us (AoU) Research Program, this multimodal framework aims to learn complex relationships between clinical data and genetic predispositions. The
Integrating Genomics into Multimodal EHR Foundation Models
-
cs.AI, q-bio.NC updates on arXiv.org
-
Quanvolutional Neural Networks for Pneumonia Detection: An Efficient Quantum-Assisted Feature Extraction Paradigm
arXiv:2510.23660v1 Announce Type: cross Abstract: Pneumonia poses a significant global health challenge, demanding accurate and timely diagnosis. While deep learning, particularly Convolutional Neural Networks (CNNs), has shown promise in medical image analysis for pneumonia detection, CNNs often suffer from high computational costs, limitations in feature representation, and challenges in generalizing from smaller datasets. To address these limitations, we explore the application of Quanvoluti
Quanvolutional Neural Networks for Pneumonia Detection: An Efficient Quantum-Assisted Feature Extraction Paradigm
-
cs.AI, q-bio.NC updates on arXiv.org
-
Closing Gaps: An Imputation Analysis of ICU Vital Signs
arXiv:2510.24217v1 Announce Type: cross Abstract: As more Intensive Care Unit (ICU) data becomes available, the interest in developing clinical prediction models to improve healthcare protocols increases. However, the lack of data quality still hinders clinical prediction using Machine Learning (ML). Many vital sign measurements, such as heart rate, contain sizeable missing segments, leaving gaps in the data that could negatively impact prediction performance. Previous works have introduced num
Closing Gaps: An Imputation Analysis of ICU Vital Signs
-
MRD
-
Dynamic Monitoring of Recurrent Ovarian Cancer Using Serial ctDNA: A Real-World Case Series
Curr Oncol. 2025 Oct 21;32(10):585. doi: 10.3390/curroncol32100585.ABSTRACTRecurrent ovarian cancer (OC) is challenging to detect early using current methods like CA-125 and imaging. Circulating tumor DNA (ctDNA) may improve disease monitoring. Here, we assess the real-world clinical utility of serial ctDNA analyses in patients with recurrent OC. We analyzed serial plasma samples (N = 23) from six patients with recurrent OC using a tumor-informed next-generation sequencing assay targeting 68 can
Dynamic Monitoring of Recurrent Ovarian Cancer Using Serial ctDNA: A Real-World Case Series
Curr Oncol. 2025 Oct 21;32(10):585. doi: 10.3390/curroncol32100585.
ABSTRACT
Recurrent ovarian cancer (OC) is challenging to detect early using current methods like CA-125 and imaging. Circulating tumor DNA (ctDNA) may improve disease monitoring. Here, we assess the real-world clinical utility of serial ctDNA analyses in patients with recurrent OC. We analyzed serial plasma samples (N = 23) from six patients with recurrent OC using a tumor-informed next-generation sequencing assay targeting 68 cancer-related genes developed at the University of Washington. ctDNA variant allele frequencies (VAFs) were correlated with CA-125 levels, radiographic findings, and clinical outcomes. ctDNA levels generally reflected clinical status, accurately mirroring disease progression and therapeutic response. In one patient, rising ctDNA preceded clinical recurrence by four months, despite normal CA-125 and imaging, highlighting its potential advantage. Conversely, some patients exhibited clinical progression with undetectable ctDNA, indicating limitations in assay sensitivity, biological factors, or metastatic sites (e.g., brain metastases). ctDNA and CA-125 showed complementary value in most cases, suggesting potential combined use in clinical monitoring. Our findings demonstrate that ctDNA is a promising biomarker to complement existing monitoring approaches for recurrent OC. In some cases, capable of predicting relapse and treatment response ahead of current clinical indicators. However, identified discordances underscore technical and biological challenges that warrant further investigation. Larger prospective studies are necessary to refine ctDNA's clinical utility and integration into personalized OC care.
PMID:41149505 | PMC:PMC12563156 | DOI:10.3390/curroncol32100585
-
cs.AI, q-bio.NC updates on arXiv.org
-
Tongyi DeepResearch Technical Report
arXiv:2510.24701v1 Announce Type: cross Abstract: We present Tongyi DeepResearch, an agentic large language model, which is specifically designed for long-horizon, deep information-seeking research tasks. To incentivize autonomous deep research agency, Tongyi DeepResearch is developed through an end-to-end training framework that combines agentic mid-training and agentic post-training, enabling scalable reasoning and information seeking across complex tasks. We design a highly scalable data syn
Tongyi DeepResearch Technical Report
-
cs.AI, q-bio.NC updates on arXiv.org
-
Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
arXiv:2510.24702v1 Announce Type: cross Abstract: Public research results on large-scale supervised finetuning of AI agents remain relatively rare, since the collection of agent training data presents unique challenges. In this work, we argue that the bottleneck is not a lack of underlying data sources, but that a large variety of data is fragmented across heterogeneous formats, tools, and interfaces. To this end, we introduce the agent data protocol (ADP), a light-weight representation languag
Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
-
cs.AI, q-bio.NC updates on arXiv.org
-
The Confidence Paradox: Can LLM Know When It's Wrong
arXiv:2506.23464v2 Announce Type: replace Abstract: Document Visual Question Answering (DocVQA) models often produce overconfident or ethically misaligned responses, especially under uncertainty. Existing models like LayoutLMv3, UDOP, and DONUT focus on accuracy but lack ethical calibration. We propose HonestVQA, a model-agnostic, self-supervised framework that aligns model confidence with correctness using weighted loss and contrastive learning. We introduce two new metrics Honesty Score (H-Sc
The Confidence Paradox: Can LLM Know When It's Wrong
-
Omics in Gastric
-
The Role of Omentin in Gastrointestinal Cancer: Diagnostic, Prognostic, and Therapeutic Perspectives
Metabolites. 2025 Sep 30;15(10):649. doi: 10.3390/metabo15100649.ABSTRACTBackground/Objectives: Omentin, also known as intelectin-1, is a secreted adipokine with anti-inflammatory, insulin-sensitizing, and immune-modulatory functions, primarily expressed in visceral adipose tissue. While omentin has been associated with favorable metabolic outcomes, its role in cancer pathogenesis appears context-dependent and remains poorly understood. This review investigates the biological functions, expressi
The Role of Omentin in Gastrointestinal Cancer: Diagnostic, Prognostic, and Therapeutic Perspectives
Metabolites. 2025 Sep 30;15(10):649. doi: 10.3390/metabo15100649.
ABSTRACT
Background/Objectives: Omentin, also known as intelectin-1, is a secreted adipokine with anti-inflammatory, insulin-sensitizing, and immune-modulatory functions, primarily expressed in visceral adipose tissue. While omentin has been associated with favorable metabolic outcomes, its role in cancer pathogenesis appears context-dependent and remains poorly understood. This review investigates the biological functions, expression patterns, and clinical relevance of omentin across gastrointestinal malignancies. Methods: A comprehensive review of the literature was conducted using PubMed, Scopus, and Web of Science up to August 2025 to evaluate the role of omentin in gastrointestinal cancers. Both preclinical and clinical studies evaluating omentin, its analogues and omentin-enhancing agents in gastric, colorectal, hepatic, pancreatic, and esophageal cancers were included. Results: Omentin exhibits anti-proliferative, anti-inflammatory, and anti-angiogenic effects within the tumor microenvironment in several GI malignancies. However, evidence also indicates a dual role. High intratumoral omentin expression correlates with improved prognosis in colorectal, gastric, and hepatic cancers; in contrast, elevated circulating levels-particularly in colorectal and pancreatic cancers-have been paradoxically associated with increased cancer risk and poor outcomes. Mechanistically, omentin modulates PI3K/Akt, NF-κB, AMPK, and oxidative stress pathways, and interacts with TMEM207. However, most available studies are small-scale and heterogeneous, with methodological inconsistencies and limited multi-omics integration, leaving major knowledge gaps. Conclusions: This review highlights omentin's distinct systemic and local roles across GI cancers, underscoring its translational implications. Omentin emerges as a promising but context-dependent biomarker and therapeutic target, with future research needed to address heterogeneity, standardize assays, and validate its clinical utility in large-scale prospective studies.
PMID:41149627 | PMC:PMC12566161 | DOI:10.3390/metabo15100649
-
cs.AI, q-bio.NC updates on arXiv.org
-
A Comprehensive Survey on Reinforcement Learning-based Agentic Search: Foundations, Roles, Optimizations, Evaluations, and Applications
arXiv:2510.16724v2 Announce Type: replace Abstract: The advent of large language models (LLMs) has transformed information access and reasoning through open-ended natural language interaction. However, LLMs remain limited by static knowledge, factual hallucinations, and the inability to retrieve real-time or domain-specific information. Retrieval-Augmented Generation (RAG) mitigates these issues by grounding model outputs in external evidence, but traditional RAG pipelines are often single turn
A Comprehensive Survey on Reinforcement Learning-based Agentic Search: Foundations, Roles, Optimizations, Evaluations, and Applications
-
cs.AI, q-bio.NC updates on arXiv.org
-
Understanding AI Trustworthiness: A Scoping Review of AIES & FAccT Articles
arXiv:2510.21293v2 Announce Type: replace Abstract: Background: Trustworthy AI serves as a foundational pillar for two major AI ethics conferences: AIES and FAccT. However, current research often adopts techno-centric approaches, focusing primarily on technical attributes such as reliability, robustness, and fairness, while overlooking the sociotechnical dimensions critical to understanding AI trustworthiness in real-world contexts. Objectives: This scoping review aims to examine how the AIES
Understanding AI Trustworthiness: A Scoping Review of AIES & FAccT Articles
-
cs.AI, q-bio.NC updates on arXiv.org
-
Multi-Agent Evolve: LLM Self-Improve through Co-evolution
arXiv:2510.23595v2 Announce Type: replace Abstract: Reinforcement Learning (RL) has demonstrated significant potential in enhancing the reasoning capabilities of large language models (LLMs). However, the success of RL for LLMs heavily relies on human-curated datasets and verifiable rewards, which limit their scalability and generality. Recent Self-Play RL methods, inspired by the success of the paradigm in games and Go, aim to enhance LLM reasoning capabilities without human-annotated data. Ho
Multi-Agent Evolve: LLM Self-Improve through Co-evolution
-
cs.AI, q-bio.NC updates on arXiv.org
-
Learned, Lagged, LLM-splained: LLM Responses to End User Security Questions
arXiv:2411.14571v2 Announce Type: replace-cross Abstract: Answering end user security questions is challenging. While large language models (LLMs) like GPT, LLAMA, and Gemini are far from error-free, they have shown promise in answering a variety of questions outside of security. We studied LLM performance in the area of end user security by qualitatively evaluating 3 popular LLMs on 900 systematically collected end user security questions. While LLMs demonstrate broad generalist ``knowledge'
Learned, Lagged, LLM-splained: LLM Responses to End User Security Questions
-
cs.AI, q-bio.NC updates on arXiv.org
-
Multimodal 3D Genome Pre-training
arXiv:2504.09060v2 Announce Type: replace-cross Abstract: Deep learning techniques have driven significant progress in various analytical tasks within 3D genomics in computational biology. However, a holistic understanding of 3D genomics knowledge remains underexplored. Here, we propose MIX-HIC, the first multimodal foundation model of 3D genome that integrates both 3D genome structure and epigenomic tracks, which obtains unified and comprehensive semantics. For accurate heterogeneous semantic
Multimodal 3D Genome Pre-training
-
cs.AI, q-bio.NC updates on arXiv.org
-
Robustness is Important: Limitations of LLMs for Data Fitting
arXiv:2508.19563v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) are being applied in a wide array of settings, well beyond the typical language-oriented use cases. In particular, LLMs are increasingly used as a plug-and-play method for fitting data and generating predictions. Prior work has shown that LLMs, via in-context learning or supervised fine-tuning, can perform competitively with many tabular supervised learning techniques in terms of predictive performance. Howev
Robustness is Important: Limitations of LLMs for Data Fitting
-
cs.AI, q-bio.NC updates on arXiv.org
-
Energy-Efficient Domain-Specific Artificial Intelligence Models and Agents: Pathways and Paradigms
arXiv:2510.22052v1 Announce Type: new Abstract: The field of artificial intelligence (AI) has taken a tight hold on broad aspects of society, industry, business, and governance in ways that dictate the prosperity and might of the world's economies. The AI market size is projected to grow from 189 billion USD in 2023 to 4.8 trillion USD by 2033. Currently, AI is dominated by large language models that exhibit linguistic and visual intelligence. However, training these models requires a massive a
Energy-Efficient Domain-Specific Artificial Intelligence Models and Agents: Pathways and Paradigms
-
cs.AI, q-bio.NC updates on arXiv.org
-
Embracing Trustworthy Brain-Agent Collaboration as Paradigm Extension for Intelligent Assistive Technologies
arXiv:2510.22095v1 Announce Type: new Abstract: Brain-Computer Interfaces (BCIs) offer a direct communication pathway between the human brain and external devices, holding significant promise for individuals with severe neurological impairments. However, their widespread adoption is hindered by critical limitations, such as low information transfer rates and extensive user-specific calibration. To overcome these challenges, recent research has explored the integration of Large Language Models (