Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Virus Infection Attack on LLMs: Your Poisoning Can Spread "VIA" Synthetic Data
arXiv:2509.23041v2 Announce Type: replace-cross Abstract: Synthetic data refers to artificial samples generated by models. While it has been validated to significantly enhance the performance of large language models (LLMs) during training and has been widely adopted in LLM development, potential security risks it may introduce remain uninvestigated. This paper systematically evaluates the resilience of synthetic-data-integrated training paradigm for LLMs against mainstream poisoning and backdo
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Nature Biotechnology - Issue - nature.com science feeds
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Scaling DNA synthesis with a microchip-based massively parallel synthesis system
Nature Biotechnology, Published online: 01 October 2025; doi:10.1038/s41587-025-02844-0A microchip-based DNA synthesis method enables scalable production of complex DNA constructs.
Scaling DNA synthesis with a microchip-based massively parallel synthesis system
Nature Biotechnology, Published online: 01 October 2025; doi:10.1038/s41587-025-02844-0
A microchip-based DNA synthesis method enables scalable production of complex DNA constructs.-
Omics In Lung
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Cell-free epigenomes enhanced fragmentomics-based model for early detection of lung cancer
Clin Transl Med. 2025 Feb;15(2):e70225. doi: 10.1002/ctm2.70225.ABSTRACTBACKGROUND: Lung cancer is a leading cause of cancer mortality, highlighting the need for innovative non-invasive early detection methods. Although cell-free DNA (cfDNA) analysis shows promise, its sensitivity in early-stage lung cancer patients remains a challenge. This study aimed to integrate insights from epigenetic modifications and fragmentomic features of cfDNA using machine learning to develop a more accurate lung ca
Cell-free epigenomes enhanced fragmentomics-based model for early detection of lung cancer
Clin Transl Med. 2025 Feb;15(2):e70225. doi: 10.1002/ctm2.70225.
ABSTRACT
BACKGROUND: Lung cancer is a leading cause of cancer mortality, highlighting the need for innovative non-invasive early detection methods. Although cell-free DNA (cfDNA) analysis shows promise, its sensitivity in early-stage lung cancer patients remains a challenge. This study aimed to integrate insights from epigenetic modifications and fragmentomic features of cfDNA using machine learning to develop a more accurate lung cancer detection model.
METHODS: To address this issue, a multi-centre prospective cohort study was conducted, with participants harbouring suspicious malignant lung nodules and healthy volunteers recruited from two clinical centres. Plasma cfDNA was analysed for its epigenetic and fragmentomic profiles using chromatin immunoprecipitation sequencing, reduced representation bisulphite sequencing and low-pass whole-genome sequencing. Machine learning algorithms were then employed to integrate the multi-omics data, aiding in the development of a precise lung cancer detection model.
RESULTS: Cancer-related changes in cfDNA fragmentomics were significantly enriched in specific genes marked by cell-free epigenomes. A total of 609 genes were identified, and the corresponding cfDNA fragmentomic features were utilised to construct the ensemble model. This model achieved a sensitivity of 90.4% and a specificity of 83.1%, with an AUC of 0.94 in the independent validation set. Notably, the model demonstrated exceptional sensitivity for stage I lung cancer cases, achieving 95.1%. It also showed remarkable performance in detecting minimally invasive adenocarcinoma, with a sensitivity of 96.2%, highlighting its potential for early detection in clinical settings.
CONCLUSIONS: With feature selection guided by multiple epigenetic sequencing approaches, the cfDNA fragmentomics-based machine learning model demonstrated outstanding performance in the independent validation cohort. These findings highlight its potential as an effective non-invasive strategy for the early detection of lung cancer.
KEYPOINTS: Our study elucidated the regulatory relationships between epigenetic modifications and their effects on fragmentomic features. Identifying epigenetically regulated genes provided a critical foundation for developing the cfDNA fragmentomics-based machine learning model. The model demonstrated exceptional clinical performance, highlighting its substantial potential for translational application in clinical practice.
PMID:39909829 | PMC:PMC11798665 | DOI:10.1002/ctm2.70225
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Nature - Issue - nature.com science feeds
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Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer
Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07379-zTumor-selective activity of RAS-GTP inhibition in pancreatic cancer
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer
Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07379-z
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer