In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunotherapies tailored for the evolving immune systems of children.

Cell Death Discovery, Published online: 14 March 2024; doi:10.1038/s41420-024-01896-6Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study