Nature, Published online: 20 October 2025; doi:10.1038/s41586-025-09713-5Parity and lactation induce T cell mediated breast cancer protection

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04160-0More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.

Nature, Published online: 04 April 2023; doi:10.1038/d41586-023-00954-wResearchers are looking to drug combinations, vaccines and gene therapy as they forge the next generation of treatments for the condition.

Nature, Published online: 16 November 2022; doi:10.1038/s41586-022-05435-0Spatial profiling and single-cell RNA sequencing are used to map the spatial distribution of the microbiota within human tumours, revealing how intratumoral microbial communities contribute to tumour heterogeneity and cancer progression.

Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05202-1A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05311-xIntratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

Over the past decade, bioethicists, legal scholars and social scientists have started to investigate the potential implications of epigenetic research and technologies on medicine and society. There is growing...