arXiv:2511.14256v1 Announce Type: new Abstract: Knowledge graph reasoning (KGR) is the task of inferring new knowledge by performing logical deductions on knowledge graphs. Recently, large language models (LLMs) have demonstrated remarkable performance in complex reasoning tasks. Despite promising success, current LLM-based KGR methods still face two critical limitations. First, existing methods often extract reasoning paths indiscriminately, without assessing their different importance, which may introduce irrelevant noise that misleads LLMs. Second, while many methods leverage LLMs to dynamically explore potential reasoning paths, they require high retrieval demands and frequent LLM calls. To address these limitations, we propose PathMind, a novel framework designed to enhance faithful and interpretable reasoning by selectively guiding LLMs with important reasoning paths. Specifically, PathMind follows a "Retrieve-Prioritize-Reason" paradigm. First, it retrieves a query subgraph from KG through the retrieval module. Next, it introduces a path prioritization mechanism that identifies important reasoning paths using a semantic-aware path priority function, which simultaneously considers the accumulative cost and the estimated future cost for reaching the target. Finally, PathMind generates accurate and logically consistent responses via a dual-phase training strategy, including task-specific instruction tuning and path-wise preference alignment. Extensive experiments on benchmark datasets demonstrate that PathMind consistently outperforms competitive baselines, particularly on complex reasoning tasks with fewer input tokens, by identifying essential reasoning paths.

arXiv:2511.14112v1 Announce Type: cross Abstract: Automatic ICD coding from clinical text is a critical task in medical NLP but remains hindered by the extreme long-tail distribution of diagnostic codes. Thousands of rare and zero-shot ICD codes are severely underrepresented in datasets like MIMIC-III, leading to low macro-F1 scores. In this work, we propose a data-centric framework that generates high-quality synthetic discharge summaries to mitigate this imbalance. Our method constructs realistic multi-label code sets anchored on rare codes by leveraging real-world co-occurrence patterns, ICD descriptions, synonyms, taxonomy, and similar clinical notes. Using these structured prompts, we generate 90,000 synthetic notes covering 7,902 ICD codes, significantly expanding the training distribution. We fine-tune two state-of-the-art transformer-based models, PLM-ICD and GKI-ICD, on both the original and extended datasets. Experiments show that our approach modestly improves macro-F1 while maintaining strong micro-F1, outperforming prior SOTA. While the gain may seem marginal relative to the computational cost, our results demonstrate that carefully crafted synthetic data can enhance equity in long-tail ICD code prediction.

arXiv:2511.14445v1 Announce Type: cross Abstract: We present Tell Me, a mental well-being system that leverages advances in large language models to provide accessible, context-aware support for users and researchers. The system integrates three components: (i) a retrieval-augmented generation (RAG) assistant for personalized, knowledge-grounded dialogue; (ii) a synthetic client-therapist dialogue generator conditioned on client profiles to facilitate research on therapeutic language and data augmentation; and (iii) a Well-being AI crew, implemented with CrewAI, that produces weekly self-care plans and guided meditation audio. The system is designed as a reflective space for emotional processing rather than a substitute for professional therapy. It illustrates how conversational assistants can lower barriers to support, complement existing care, and broaden access to mental health resources. To address the shortage of confidential therapeutic data, we introduce synthetic client-therapist dialogue generation conditioned on client profiles. Finally, the planner demonstrates an innovative agentic workflow for dynamically adaptive, personalized self-care, bridging the limitations of static well-being tools. We describe the architecture, demonstrate its functionalities, and report evaluation of the RAG assistant in curated well-being scenarios using both automatic LLM-based judgments and a human-user study. This work highlights opportunities for interdisciplinary collaboration between NLP researchers and mental health professionals to advance responsible innovation in human-AI interaction for well-being.

Nature, Published online: 18 November 2025; doi:10.1038/d41586-025-03718-w

A thorough examination of artificial intelligence’s promise in politics rests on a thorny premise: democracy is an information system.

Scientists discovered that alcohol activates a sugar-producing pathway in the body, creating fructose that may reinforce addictive drinking. The enzyme responsible, KHK, appears to drive both alcohol cravings and liver injury. When this enzyme was blocked in mice, their drinking decreased and their livers showed far less damage.

arXiv:2407.04055v2 Announce Type: replace-cross Abstract: The prediction modeling of drug-target interactions is crucial to drug discovery and design, which has seen rapid advancements owing to deep learning technologies. Recently developed methods, such as those based on graph neural networks (GNNs) and Transformers, demonstrate exceptional performance across various datasets by effectively extracting structural information. However, the benchmarking of these novel methods often varies significantly in terms of hyperparameter settings and datasets, which limits algorithmic progress. In view of these, we conducted a comprehensive survey and benchmark for drug-target interaction modeling from a structural perspective via integrating tens of explicit (i.e., GNN-based) and implicit (i.e., Transformer-based) structure learning algorithms. We conducted a macroscopical comparison between these two classes of encoding strategies as well as the different featurization techniques that inform molecules' chemical and physical properties. We then carry out the microscopical comparison between all the integrated models across the six datasets via comprehensively benchmarking their effectiveness and efficiency. To ensure fairness, we investigate model performance under individually optimized configuration. Remarkably, the summarized insights from the benchmark studies lead to the design of model combos. We demonstrate that our combos can achieve new state-of-the-art performance on various datasets associated with cost-effective memory and computation.

The Ryder Cup is an almost-century-old tournament pitting Europe against the United States in an elite showcase of golf skill and strategy. At the 2025 event, nearly a quarter of a million spectators gathered to watch three days of fierce competition on the fairways.

From a technology and logistics perspective, pulling off an event of this scale is no easy feat. The Ryder Cup’s infrastructure must accommodate the tens of thousands of network users who flood the venue (this year, at Bethpage Black in Farmingdale, New York) every day.

To manage this IT complexity, Ryder Cup engaged technology partner HPE to create a central hub for its operations. The solution centered around a platform where tournament staff could access data visualization supporting operational decision-making. This dashboard, which leveraged a high-performance network and private-cloud environment, aggregated and distilled insights from diverse real-time data feeds.

It was a glimpse into what AI-ready networking looks like at scale—a real-world stress test with implications for everything from event management to enterprise operations. While models and data readiness get the lion’s share of boardroom attention and media hype, networking is a critical third leg of successful AI implementation, explains Jon Green, CTO of HPE Networking. “Disconnected AI doesn’t get you very much; you need a way to get data into it and out of it for both training and inference,” he says.

As businesses move toward distributed, real-time AI applications, tomorrow’s networks will need to parse even more massive volumes of information at ever more lightning-fast speeds. What played out on the greens at Bethpage Black represents a lesson being learned across industries: Inference-ready networks are a make-or-break factor for turning AI’s promise into real-world performance.

Making a network AI inference-ready

More than half of organizations are still struggling to operationalize their data pipelines. In a recent HPE cross-industry survey of 1,775  IT leaders, 45% said they could run real-time data pushes and pulls for innovation. It’s a noticeable change over last year’s numbers (just 7% reported having such capabilities in 2024), but there’s still work to be done to connect data collection with real-time decision-making.

The network may hold the key to further narrowing that gap. Part of the solution will likely come down to infrastructure design. While traditional enterprise networks are engineered to handle the predictable flow of business applications—email, browsers, file sharing, etc.—they’re not designed to field the dynamic, high-volume data movement required by AI workloads. Inferencing in particular depends on shuttling vast datasets between multiple GPUs with supercomputer-like precision.

“There’s an ability to play fast and loose with a standard, off-the-shelf enterprise network,” says Green. “Few will notice if an email platform is half a second slower than it might’ve been. But with AI transaction processing, the entire job is gated by the last calculation taking place. So it becomes really noticeable if you’ve got any loss or congestion.”

Networks built for AI, therefore, must operate with a different set of performance characteristics, including ultra-low latency, lossless throughput, specialized equipment, and adaptability at scale. One of these differences is AI’s distributed nature, which affects the seamless flow of data.

The Ryder Cup was a vivid demonstration of this new class of networking in action. During the event, a Connected Intelligence Center was put in place to ingest data from ticket scans, weather reports, GPS-tracked golf carts, concession and merchandise sales, spectator and consumer queues, and network performance. Additionally, 67 AI-enabled cameras were positioned throughout the course. Inputs were analyzed through an operational intelligence dashboard and provided staff with an instantaneous view of activity across the grounds.

“The tournament is really complex from a networking perspective, because you have many big open areas that aren’t uniformly packed with people,” explains Green. “People tend to follow the action. So in certain areas, it’s really dense with lots of people and devices, while other areas are completely empty.”

To handle that variability, engineers built out a two-tiered architecture. Across the sprawling venue, more than 650 WiFi 6E access points, 170 network switches, and 25 user experience sensors worked together to maintain continuous connectivity and feed a private cloud AI cluster for live analytics. The front-end layer connected cameras, sensors, and access points to capture live video and movement data, while a back-end layer—located within a temporary on-site data center—linked GPUs and servers in a high-speed, low-latency configuration that effectively served as the system’s brain. Together, the setup enabled both rapid on-the-ground responses and data collection that could inform future operational planning. “AI models also were available to the team which could process video of the shots taken and help determine, from the footage, which ones were the most interesting,” says Green.

Physical AI and the return of on-prem intelligence

If time is of the essence for event management, it’s even more critical in contexts where safety is on the line—for instance a self-driving car making a split-second decision to accelerate or brake.

In planning for the rise of physical AI, where applications move off screens and onto factory floors and city streets, a growing number of enterprises are rethinking their architectures. Instead of sending the data to centralized clouds for inference, some are deploying edge-based AI clusters that process information closer to where it is generated. Data-intensive training may still occur in the cloud, but inferencing happens on-site.

This hybrid approach is fueling a wave of operational repatriation, as workloads once relegated to the cloud return to on-premises infrastructure for enhanced speed, security, sovereignty, and cost reasons. “We’ve had an out-migration of IT into the cloud in recent years, but physical AI is one of the use cases that we believe will bring a lot of that back on-prem,” predicts Green, giving the example of an AI-infused factory floor, where a round-trip of sensor data to the cloud would be too slow to safely control automated machinery. “By the time processing happens in the cloud, the machine has already moved,” he explains.

There’s data to back up Green’s projection: research from Enterprise Research Group shows that 84% of respondents are reevaluating application deployment strategies due to the growth of AI. Market forecasts also reflect this shift. According to IDC, the AI market for infrastructure is expected to reach $758 billion by 2029.

AI for networking and the future of self-driving infrastructure

The relationship between networking and AI is circular: Modern networks make AI at scale possible, but AI is also helping make networks smarter and more capable.

“Networks are some of the most data-rich systems in any organization,” says Green. “That makes them a perfect use case for AI. We can analyze millions of configuration states across thousands of customer environments and learn what actually improves performance or stability.”

At HPE for example, which has one of the largest network telemetry repositories in the world, AI models analyze anonymized data collected from billions of connected devices to identify trends and refine behavior over time. The platform processes more than a trillion telemetry points each day, which means it can continuously learn from real-world conditions.

The concept broadly known as AIOps (or AI-driven IT operations) is changing how enterprise networks are managed across industries. Today, AI surfaces insights as recommendations that administrators can choose to apply with a single click. Tomorrow, those same systems might automatically test and deploy low-risk changes themselves.

That long-term vision, Green notes, is referred to as a “self-driving network”—one that handles the repetitive, error-prone tasks that have historically plagued IT teams. “AI isn’t coming for the network engineer’s job, but it will eliminate the tedious stuff that slows them down,” he says. “You’ll be able to say, ‘Please go configure 130 switches to solve this issue,’ and the system will handle it. When a port gets stuck or someone plugs a connector in the wrong direction, AI can detect it—and in many cases, fix it automatically.”

Digital initiatives now depend on how effectively information moves. Whether coordinating a live event or streamlining a supply chain, the performance of the network increasingly defines the performance of the business. Building that foundation today will separate those who pilot from those who scale AI.

For more, register to watch MIT Technology Review’s EmTech AI Salon, featuring HPE.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff. It was researched, designed, and written by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

Oncogenesis, Published online: 18 November 2025; doi:10.1038/s41389-025-00585-y

Sphingosine 1-phosphate signalling in cancer stem cells

arXiv:2506.09095v4 Announce Type: replace-cross Abstract: Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features that can later be adapted to specific clinical tasks with little additional supervision. In this review, we examine how FMs are being developed and applied in pathology, radiology, and ophthalmology, drawing on evidence from over 150 studies. We explain the core components of FM pipelines, including model architectures, self-supervised learning methods, and strategies for downstream adaptation. We also review how FMs are being used in each imaging domain and compare design choices across applications. Finally, we discuss key challenges and open questions to guide future research.

npj Digital Medicine, Published online: 18 November 2025; doi:10.1038/s41746-025-02066-3

Reply to: Utilizing foundation models for developing clinical tools

arXiv:2511.11587v2 Announce Type: replace-cross Abstract: Globally, disparities in healthcare infrastructure remain stark, leaving countless communities without access to even basic services. Traditional infrastructure planning is often slow and inaccessible, and although many architects are actively delivering humanitarian and aid-driven hospital projects worldwide, these vital efforts still fall far short of the sheer scale and urgency of demand. This paper introduces MedBuild AI, a hybrid-intelligence framework that integrates large language models (LLMs) with deterministic expert systems to rebalance the early design and conceptual planning stages. As a web-based platform, it enables any region with satellite internet access to obtain guidance on modular, low-tech, low-cost medical building designs. The system operates through three agents: the first gathers local health intelligence via conversational interaction; the second translates this input into an architectural functional program through rule-based computation; and the third generates layouts and 3D models. By embedding computational negotiation into the design process, MedBuild AI fosters a reciprocal, inclusive, and equitable approach to healthcare planning, empowering communities and redefining agency in global healthcare architecture.

arXiv:2511.11590v2 Announce Type: replace-cross Abstract: Artificial intelligence (AI) is increasingly embedded in NHS workflows, but its probabilistic and adaptive behaviour conflicts with the deterministic assumptions underpinning existing clinical-safety standards. DCB0129 and DCB0160 provide strong governance for conventional software yet do not define how AI-specific transparency, interpretability, or model drift should be evidenced within Safety Cases, Hazard Logs, or post-market monitoring. This paper proposes an Explainability-Enabled Clinical Safety Framework (ECSF) that integrates explainability into the DCB0129/0160 lifecycle, enabling Clinical Safety Officers to use interpretability outputs as structured safety evidence without altering compliance pathways. A cross-regulatory synthesis mapped DCB clauses to principles from Good Machine Learning Practice, the NHS AI Assurance and T.E.S.T. frameworks, and the EU AI Act. The resulting matrix links regulatory clauses, principles, ECSF checkpoints, and suitable explainability outputs. ECSF introduces five checkpoints: global transparency for hazard identification, case-level interpretability for verification, clinician usability for evaluation, traceable decision pathways for risk control, and longitudinal interpretability monitoring for post-market surveillance. Techniques such as SHAP, LIME, Integrated Gradients, saliency mapping, and attention visualisation are mapped to corresponding DCB artefacts. ECSF reframes explainability as a core element of clinical-safety assurance, bridging deterministic risk governance with the probabilistic behaviour of AI and supporting alignment with GMLP, the EU AI Act, and NHS AI Assurance principles.

npj Digital Medicine, Published online: 18 November 2025; doi:10.1038/s41746-025-02042-x

Large language models driven neural architecture search for universal and lightweight disease diagnosis on histopathology slide images

arXiv:2511.11597v1 Announce Type: new Abstract: Evaluating how Large Language Models (LLMs) handle complex, specialized knowledge remains a critical challenge. We address this through the lens of climate change by introducing CLINB, a benchmark that assesses models on open-ended, grounded, multimodal question answering tasks with clear requirements for knowledge quality and evidential support. CLINB relies on a dataset of real users' questions and evaluation rubrics curated by leading climate scientists. We implement and validate a model-based evaluation process and evaluate several frontier models. Our findings reveal a critical dichotomy. Frontier models demonstrate remarkable knowledge synthesis capabilities, often exhibiting PhD-level understanding and presentation quality. They outperform "hybrid" answers curated by domain experts assisted by weaker models. However, this performance is countered by failures in grounding. The quality of evidence varies, with substantial hallucination rates for references and images. We argue that bridging this gap between knowledge synthesis and verifiable attribution is essential for the deployment of AI in scientific workflows and that reliable, interpretable benchmarks like CLINB are needed to progress towards building trustworthy AI systems.

arXiv:2511.11899v1 Announce Type: new Abstract: Fine-grained analysis of intraoperative behavior and its impact on patient outcomes remain a longstanding challenge. We present Frame-to-Outcome (F2O), an end-to-end system that translates tissue dissection videos into gesture sequences and uncovers patterns associated with postoperative outcomes. Leveraging transformer-based spatial and temporal modeling and frame-wise classification, F2O robustly detects consecutive short (~2 seconds) gestures in the nerve-sparing step of robot-assisted radical prostatectomy (AUC: 0.80 frame-level; 0.81 video-level). F2O-derived features (gesture frequency, duration, and transitions) predicted postoperative outcomes with accuracy comparable to human annotations (0.79 vs. 0.75; overlapping 95% CI). Across 25 shared features, effect size directions were concordant with small differences (~ 0.07), and strong correlation (r = 0.96, p

arXiv:2511.12239v1 Announce Type: new Abstract: World models have garnered substantial interest in the AI community. These are internal representations that simulate aspects of the external world, track entities and states, capture causal relationships, and enable prediction of consequences. This contrasts with representations based solely on statistical correlations. A key motivation behind this research direction is that humans possess such mental world models, and finding evidence of similar representations in AI models might indicate that these models "understand" the world in a human-like way. In this paper, we use case studies from the philosophy of science literature to critically examine whether the world model framework adequately characterizes human-level understanding. We focus on specific philosophical analyses where the distinction between world model capabilities and human understanding is most pronounced. While these represent particular views of understanding rather than universal definitions, they help us explore the limits of world models.

arXiv:2511.12306v1 Announce Type: new Abstract: As large language model (LLM) agents increasingly undertake digital work, reliable frameworks are needed to evaluate their real-world competence, adaptability, and capacity for human collaboration. Existing benchmarks remain largely static, synthetic, or domain-limited, providing limited insight into how agents perform in dynamic, economically meaningful environments. We introduce UpBench, a dynamically evolving benchmark grounded in real jobs drawn from the global Upwork labor marketplace. Each task corresponds to a verified client transaction, anchoring evaluation in genuine work activity and financial outcomes. UpBench employs a rubric-based evaluation framework, in which expert freelancers decompose each job into detailed, verifiable acceptance criteria and assess AI submissions with per-criterion feedback. This structure enables fine-grained analysis of model strengths, weaknesses, and instruction-following fidelity beyond binary pass/fail metrics. Human expertise is integrated throughout the data pipeline (from job curation and rubric construction to evaluation) ensuring fidelity to real professional standards and supporting research on human-AI collaboration. By regularly refreshing tasks to reflect the evolving nature of online work, UpBench provides a scalable, human-centered foundation for evaluating agentic systems in authentic labor-market contexts, offering a path toward a collaborative framework, where AI amplifies human capability through partnership rather than replacement.

arXiv:2511.12378v1 Announce Type: new Abstract: Autonomous agents operating in sequential decision-making tasks under uncertainty can benefit from external action suggestions, which provide valuable guidance but inherently vary in reliability. Existing methods for incorporating such advice typically assume static and known suggester quality parameters, limiting practical deployment. We introduce a framework that dynamically learns and adapts to varying suggester reliability in partially observable environments. First, we integrate suggester quality directly into the agent's belief representation, enabling agents to infer and adjust their reliance on suggestions through Bayesian inference over suggester types. Second, we introduce an explicit ``ask'' action allowing agents to strategically request suggestions at critical moments, balancing informational gains against acquisition costs. Experimental evaluation demonstrates robust performance across varying suggester qualities, adaptation to changing reliability, and strategic management of suggestion requests. This work provides a foundation for adaptive human-agent collaboration by addressing suggestion uncertainty in uncertain environments.

arXiv:2511.12439v1 Announce Type: new Abstract: Online health resources and large language models (LLMs) are increasingly used as a first point of contact for medical decision-making, yet their reliability in healthcare remains limited by low accuracy, lack of transparency, and susceptibility to unverified information. We introduce a proof-of-concept conversational self-triage system that guides LLMs with 100 clinically validated flowcharts from the American Medical Association, providing a structured and auditable framework for patient decision support. The system leverages a multi-agent framework consisting of a retrieval agent, a decision agent, and a chat agent to identify the most relevant flowchart, interpret patient responses, and deliver personalized, patient-friendly recommendations, respectively. Performance was evaluated at scale using synthetic datasets of simulated conversations. The system achieved 95.29% top-3 accuracy in flowchart retrieval (N=2,000) and 99.10% accuracy in flowchart navigation across varied conversational styles and conditions (N=37,200). By combining the flexibility of free-text interaction with the rigor of standardized clinical protocols, this approach demonstrates the feasibility of transparent, accurate, and generalizable AI-assisted self-triage, with potential to support informed patient decision-making while improving healthcare resource utilization.

arXiv:2511.12916v1 Announce Type: new Abstract: Power grid fault diagnosis is a critical process hindered by its reliance on manual, error-prone methods. Technicians must manually extract reasoning logic from dense regulations and attempt to combine it with tacit expert knowledge, which is inefficient, error-prone, and lacks maintainability as ragulations are updated and experience evolves. While Large Language Models (LLMs) have shown promise in parsing unstructured text, no existing framework integrates these two disparate knowledge sources into a single, verified, and executable workflow. To bridge this gap, we propose Fault2Flow, an LLM-based multi-agent system. Fault2Flow systematically: (1) extracts and structures regulatory logic into PASTA-formatted fault trees; (2) integrates expert knowledge via a human-in-the-loop interface for verification; (3) optimizes the reasoning logic using a novel AlphaEvolve module; and (4) synthesizes the final, verified logic into an n8n-executable workflow. Experimental validation on transformer fault diagnosis datasets confirms 100\% topological consistency and high semantic fidelity. Fault2Flow establishes a reproducible path from fault analysis to operational automation, substantially reducing expert workload.