Background: The rapid advancement of digital health technologies (DHTs) offers substantial potential for improving healthcare access, yet it simultaneously risks exacerbating existing inequities for marginalized populations. Previous research on the digital divide has often treated individuals with blindness as a homogenous group, primarily focusing on barriers related to digital access and skills. However, less is known about the nuanced experiences of specific subgroups, such as educated and digitally literate young adults. This study focuses on this demographic to understand how their advanced digital capabilities interact with systemic and infrastructural barriers in healthcare. Objective: This qualitative study aimed to explore the lived healthcare experiences of educated young adults with blindness in China, specifically identifying how DHTs simultaneously contribute to their empowerment and exclusion. Methods: Eligible participants were educated young adults with blindness in China (aged 18-30 years, Mandarin speakers, smartphone users, and holding or pursuing higher education). A total of 12 semi-structured interviews were conducted in Mandarin during September 2024. All interviews were audio-recorded and transcribed verbatim. An inductive thematic analysis was employed to interpret the data and identify key themes. Results: Participants’ experiences highlighted an “empowered but excluded” dynamic. Seven key themes emerged, categorized into empowerment and exclusion. Empowerment themes included: (1) digital platforms empowering self-management and healthcare access, where DHTs enabled independent appointment booking and access to comprehensive health information; and (2) digital platforms empowering for finding medical visit companions, facilitating the discovery of companions for physical and emotional support. Exclusion themes comprised: (3) inaccessible online appointment systems, due to non-inclusive designs; (4) inaccessible healthcare environments and information formats, stemming from non-accessible self-service machines and written materials; (5) lack of provider competencies in respecting patient autonomy, as providers often assumed digital incompetence; (6) data privacy and security concerns, heightened by increased digitalization and reliance on assistive tools; and (7) challenges related to the quality and consistency of online companion support, highlighting the limitations of platform-based assistance. Conclusions: Our findings reveal an “empowered but excluded” dynamic: the potential for digital empowerment and enhanced independence is often curtailed by systematic barriers. Addressing this necessitates a multifaceted approach: enhancing technological accessibility through robust standards adherence and inclusive co-design processes; improving healthcare provider competencies in patient-centered care via targeted training; and empowering educated young blind adults by building their capacity for self-determination to achieve equitable healthcare access.

Background: The application of large language models (LLMs) in health care holds significant potential for enhancing patient care and advancing medical research. However, the protection of patient privacy remains a critical issue, especially when handling patient health information (PHI). Objective: This scoping review aims to evaluate the adequacy of current approaches and identify areas in need of improvement to ensure robust patient privacy protection in the existing studies about PHI-LLMs within the health care domain. Methods: A search of the literature published from January 1, 2022, to July 20, 2025, was performed on July 20, 2025, using 2 databases (PubMed and Embase). This scoping review focused on the following three research questions: (1) What studies on the development and application of LLMs using PHI currently exist within the health care domain? (2) What patient privacy considerations are addressed in existing PHI-LLMs research, and are these measures sufficient? (3) How can future research on the development and application of LLMs using PHI better protect patient privacy? Studies were included if they focused on the development and application of LLMs within health care using PHI, encompassing activities such as model construction, fine-tuning, optimization, testing, and performance comparison. Eligible literature comprised original research articles written in English. Conversely, studies were excluded if they used publicly available datasets, under the assumption that such data have been adequately deidentified. Additionally, non-English publications, reviews, abstracts, incomplete reports, and preprints were excluded from the review due to the lack of rigorous peer review. Results: This study systematically identified 9823 studies on PHI-LLM and included 464 studies published between 2022 and 2025. Among the 464 studies, (1) a small number of studies neglected ethical review (n=45, 9.7%) and patient informed consent (n=148, 31.9%) during the research process, (2) more than a third of the studies (n=178, 38.4%) failed to report whether to implement effective measures to protect PHI, and (3) there was a significant lack of transparency and comprehensive detail in anonymization and deidentification methods. Conclusions: We propose comprehensive recommendations across 3 phases—study design, implementation, and reporting—to strengthen patient privacy protection and transparency in PHI-LLM. This study emphasizes the urgent need for the development of stricter regulatory frameworks and the adoption of advanced privacy protection technologies to effectively safeguard PHI. It is anticipated that future applications of LLMs in the health care field will achieve a balance between innovation and robust patient privacy protection, thereby enhancing ethical standards and scientific credibility.

Nature Biotechnology, Published online: 21 November 2025; doi:10.1038/s41587-025-02897-1

Translation can be initiated from a specific start codon using trans-RNA.

The use of vaginal self-sampling for cervical cancer screening is promising and increasing. However, triage cytology cannot be performed on vaginal self-sampling material after a high-risk human papilloma viru...

arXiv:2511.15061v1 Announce Type: new Abstract: Genomic question answering often requires complex reasoning and integration across diverse biomedical sources. GeneGPT addressed this challenge by combining domain-specific APIs with OpenAI's code-davinci-002 large language model to enable natural language interaction with genomic databases. However, its reliance on a proprietary model limits scalability, increases operational costs, and raises concerns about data privacy and generalization. In this work, we revisit and reproduce GeneGPT in a pilot study using open source models, including Llama 3.1, Qwen2.5, and Qwen2.5 Coder, within a monolithic architecture; this allows us to identify the limitations of this approach. Building on this foundation, we then develop OpenBioLLM, a modular multi-agent framework that extends GeneGPT by introducing agent specialization for tool routing, query generation, and response validation. This enables coordinated reasoning and role-based task execution. OpenBioLLM matches or outperforms GeneGPT on over 90% of the benchmark tasks, achieving average scores of 0.849 on Gene-Turing and 0.830 on GeneHop, while using smaller open-source models without additional fine-tuning or tool-specific pretraining. OpenBioLLM's modular multi-agent design reduces latency by 40-50% across benchmark tasks, significantly improving efficiency without compromising model capability. The results of our comprehensive evaluation highlight the potential of open-source multi-agent systems for genomic question answering. Code and resources are available at https://github.com/ielab/OpenBioLLM.

arXiv:2511.15534v1 Announce Type: new Abstract: There is growing interest in using AI agents for scientific research, yet fundamental questions remain about their capabilities as scientists and reviewers. To explore these questions, we organized Agents4Science, the first conference in which AI agents serve as both primary authors and reviewers, with humans as co-authors and co-reviewers. Here, we discuss the key learnings from the conference and their implications for human-AI collaboration in science.

arXiv:2511.11743v2 Announce Type: replace-cross Abstract: Deploying deep neural networks on resource-constrained devices faces two critical challenges: maintaining accuracy under aggressive quantization while ensuring predictable inference latency. We present a curiosity-driven quantized Mixture-of-Experts framework that addresses both through Bayesian epistemic uncertainty-based routing across heterogeneous experts (BitNet ternary, 1-16 bit BitLinear, post-training quantization). Evaluated on audio classification benchmarks (ESC-50, Quinn, UrbanSound8K), our 4-bit quantization maintains 99.9 percent of 16-bit accuracy (0.858 vs 0.859 F1) with 4x compression and 41 percent energy savings versus 8-bit. Crucially, curiosity-driven routing reduces MoE latency variance by 82 percent (p = 0.008, Levene's test) from 230 ms to 29 ms standard deviation, enabling stable inference for battery-constrained devices. Statistical analysis confirms 4-bit/8-bit achieve practical equivalence with full precision (p > 0.05), while MoE architectures introduce 11 percent latency overhead (p

Nature Cancer, Published online: 19 November 2025; doi:10.1038/s43018-025-01060-8

Gao et al. present SMMILe, a multiple-instance learning-based tool that leverages whole-slide images for accurate spatial quantification without compromising on classification performance, and show it outperforms state-of-the-art methods.

Nature Biotechnology, Published online: 19 November 2025; doi:10.1038/s41587-025-02929-w

Need for a shared language and minimum information standards for bioprocess development

arXiv:2407.04055v2 Announce Type: replace-cross Abstract: The prediction modeling of drug-target interactions is crucial to drug discovery and design, which has seen rapid advancements owing to deep learning technologies. Recently developed methods, such as those based on graph neural networks (GNNs) and Transformers, demonstrate exceptional performance across various datasets by effectively extracting structural information. However, the benchmarking of these novel methods often varies significantly in terms of hyperparameter settings and datasets, which limits algorithmic progress. In view of these, we conducted a comprehensive survey and benchmark for drug-target interaction modeling from a structural perspective via integrating tens of explicit (i.e., GNN-based) and implicit (i.e., Transformer-based) structure learning algorithms. We conducted a macroscopical comparison between these two classes of encoding strategies as well as the different featurization techniques that inform molecules' chemical and physical properties. We then carry out the microscopical comparison between all the integrated models across the six datasets via comprehensively benchmarking their effectiveness and efficiency. To ensure fairness, we investigate model performance under individually optimized configuration. Remarkably, the summarized insights from the benchmark studies lead to the design of model combos. We demonstrate that our combos can achieve new state-of-the-art performance on various datasets associated with cost-effective memory and computation.

The Ryder Cup is an almost-century-old tournament pitting Europe against the United States in an elite showcase of golf skill and strategy. At the 2025 event, nearly a quarter of a million spectators gathered to watch three days of fierce competition on the fairways.

From a technology and logistics perspective, pulling off an event of this scale is no easy feat. The Ryder Cup’s infrastructure must accommodate the tens of thousands of network users who flood the venue (this year, at Bethpage Black in Farmingdale, New York) every day.

To manage this IT complexity, Ryder Cup engaged technology partner HPE to create a central hub for its operations. The solution centered around a platform where tournament staff could access data visualization supporting operational decision-making. This dashboard, which leveraged a high-performance network and private-cloud environment, aggregated and distilled insights from diverse real-time data feeds.

It was a glimpse into what AI-ready networking looks like at scale—a real-world stress test with implications for everything from event management to enterprise operations. While models and data readiness get the lion’s share of boardroom attention and media hype, networking is a critical third leg of successful AI implementation, explains Jon Green, CTO of HPE Networking. “Disconnected AI doesn’t get you very much; you need a way to get data into it and out of it for both training and inference,” he says.

As businesses move toward distributed, real-time AI applications, tomorrow’s networks will need to parse even more massive volumes of information at ever more lightning-fast speeds. What played out on the greens at Bethpage Black represents a lesson being learned across industries: Inference-ready networks are a make-or-break factor for turning AI’s promise into real-world performance.

Making a network AI inference-ready

More than half of organizations are still struggling to operationalize their data pipelines. In a recent HPE cross-industry survey of 1,775  IT leaders, 45% said they could run real-time data pushes and pulls for innovation. It’s a noticeable change over last year’s numbers (just 7% reported having such capabilities in 2024), but there’s still work to be done to connect data collection with real-time decision-making.

The network may hold the key to further narrowing that gap. Part of the solution will likely come down to infrastructure design. While traditional enterprise networks are engineered to handle the predictable flow of business applications—email, browsers, file sharing, etc.—they’re not designed to field the dynamic, high-volume data movement required by AI workloads. Inferencing in particular depends on shuttling vast datasets between multiple GPUs with supercomputer-like precision.

“There’s an ability to play fast and loose with a standard, off-the-shelf enterprise network,” says Green. “Few will notice if an email platform is half a second slower than it might’ve been. But with AI transaction processing, the entire job is gated by the last calculation taking place. So it becomes really noticeable if you’ve got any loss or congestion.”

Networks built for AI, therefore, must operate with a different set of performance characteristics, including ultra-low latency, lossless throughput, specialized equipment, and adaptability at scale. One of these differences is AI’s distributed nature, which affects the seamless flow of data.

The Ryder Cup was a vivid demonstration of this new class of networking in action. During the event, a Connected Intelligence Center was put in place to ingest data from ticket scans, weather reports, GPS-tracked golf carts, concession and merchandise sales, spectator and consumer queues, and network performance. Additionally, 67 AI-enabled cameras were positioned throughout the course. Inputs were analyzed through an operational intelligence dashboard and provided staff with an instantaneous view of activity across the grounds.

“The tournament is really complex from a networking perspective, because you have many big open areas that aren’t uniformly packed with people,” explains Green. “People tend to follow the action. So in certain areas, it’s really dense with lots of people and devices, while other areas are completely empty.”

To handle that variability, engineers built out a two-tiered architecture. Across the sprawling venue, more than 650 WiFi 6E access points, 170 network switches, and 25 user experience sensors worked together to maintain continuous connectivity and feed a private cloud AI cluster for live analytics. The front-end layer connected cameras, sensors, and access points to capture live video and movement data, while a back-end layer—located within a temporary on-site data center—linked GPUs and servers in a high-speed, low-latency configuration that effectively served as the system’s brain. Together, the setup enabled both rapid on-the-ground responses and data collection that could inform future operational planning. “AI models also were available to the team which could process video of the shots taken and help determine, from the footage, which ones were the most interesting,” says Green.

Physical AI and the return of on-prem intelligence

If time is of the essence for event management, it’s even more critical in contexts where safety is on the line—for instance a self-driving car making a split-second decision to accelerate or brake.

In planning for the rise of physical AI, where applications move off screens and onto factory floors and city streets, a growing number of enterprises are rethinking their architectures. Instead of sending the data to centralized clouds for inference, some are deploying edge-based AI clusters that process information closer to where it is generated. Data-intensive training may still occur in the cloud, but inferencing happens on-site.

This hybrid approach is fueling a wave of operational repatriation, as workloads once relegated to the cloud return to on-premises infrastructure for enhanced speed, security, sovereignty, and cost reasons. “We’ve had an out-migration of IT into the cloud in recent years, but physical AI is one of the use cases that we believe will bring a lot of that back on-prem,” predicts Green, giving the example of an AI-infused factory floor, where a round-trip of sensor data to the cloud would be too slow to safely control automated machinery. “By the time processing happens in the cloud, the machine has already moved,” he explains.

There’s data to back up Green’s projection: research from Enterprise Research Group shows that 84% of respondents are reevaluating application deployment strategies due to the growth of AI. Market forecasts also reflect this shift. According to IDC, the AI market for infrastructure is expected to reach $758 billion by 2029.

AI for networking and the future of self-driving infrastructure

The relationship between networking and AI is circular: Modern networks make AI at scale possible, but AI is also helping make networks smarter and more capable.

“Networks are some of the most data-rich systems in any organization,” says Green. “That makes them a perfect use case for AI. We can analyze millions of configuration states across thousands of customer environments and learn what actually improves performance or stability.”

At HPE for example, which has one of the largest network telemetry repositories in the world, AI models analyze anonymized data collected from billions of connected devices to identify trends and refine behavior over time. The platform processes more than a trillion telemetry points each day, which means it can continuously learn from real-world conditions.

The concept broadly known as AIOps (or AI-driven IT operations) is changing how enterprise networks are managed across industries. Today, AI surfaces insights as recommendations that administrators can choose to apply with a single click. Tomorrow, those same systems might automatically test and deploy low-risk changes themselves.

That long-term vision, Green notes, is referred to as a “self-driving network”—one that handles the repetitive, error-prone tasks that have historically plagued IT teams. “AI isn’t coming for the network engineer’s job, but it will eliminate the tedious stuff that slows them down,” he says. “You’ll be able to say, ‘Please go configure 130 switches to solve this issue,’ and the system will handle it. When a port gets stuck or someone plugs a connector in the wrong direction, AI can detect it—and in many cases, fix it automatically.”

Digital initiatives now depend on how effectively information moves. Whether coordinating a live event or streamlining a supply chain, the performance of the network increasingly defines the performance of the business. Building that foundation today will separate those who pilot from those who scale AI.

For more, register to watch MIT Technology Review’s EmTech AI Salon, featuring HPE.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff. It was researched, designed, and written by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

arXiv:2506.09095v4 Announce Type: replace-cross Abstract: Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features that can later be adapted to specific clinical tasks with little additional supervision. In this review, we examine how FMs are being developed and applied in pathology, radiology, and ophthalmology, drawing on evidence from over 150 studies. We explain the core components of FM pipelines, including model architectures, self-supervised learning methods, and strategies for downstream adaptation. We also review how FMs are being used in each imaging domain and compare design choices across applications. Finally, we discuss key challenges and open questions to guide future research.

npj Digital Medicine, Published online: 18 November 2025; doi:10.1038/s41746-025-02042-x

Large language models driven neural architecture search for universal and lightweight disease diagnosis on histopathology slide images

arXiv:2511.11597v1 Announce Type: new Abstract: Evaluating how Large Language Models (LLMs) handle complex, specialized knowledge remains a critical challenge. We address this through the lens of climate change by introducing CLINB, a benchmark that assesses models on open-ended, grounded, multimodal question answering tasks with clear requirements for knowledge quality and evidential support. CLINB relies on a dataset of real users' questions and evaluation rubrics curated by leading climate scientists. We implement and validate a model-based evaluation process and evaluate several frontier models. Our findings reveal a critical dichotomy. Frontier models demonstrate remarkable knowledge synthesis capabilities, often exhibiting PhD-level understanding and presentation quality. They outperform "hybrid" answers curated by domain experts assisted by weaker models. However, this performance is countered by failures in grounding. The quality of evidence varies, with substantial hallucination rates for references and images. We argue that bridging this gap between knowledge synthesis and verifiable attribution is essential for the deployment of AI in scientific workflows and that reliable, interpretable benchmarks like CLINB are needed to progress towards building trustworthy AI systems.

arXiv:2511.11899v1 Announce Type: new Abstract: Fine-grained analysis of intraoperative behavior and its impact on patient outcomes remain a longstanding challenge. We present Frame-to-Outcome (F2O), an end-to-end system that translates tissue dissection videos into gesture sequences and uncovers patterns associated with postoperative outcomes. Leveraging transformer-based spatial and temporal modeling and frame-wise classification, F2O robustly detects consecutive short (~2 seconds) gestures in the nerve-sparing step of robot-assisted radical prostatectomy (AUC: 0.80 frame-level; 0.81 video-level). F2O-derived features (gesture frequency, duration, and transitions) predicted postoperative outcomes with accuracy comparable to human annotations (0.79 vs. 0.75; overlapping 95% CI). Across 25 shared features, effect size directions were concordant with small differences (~ 0.07), and strong correlation (r = 0.96, p

arXiv:2511.12306v1 Announce Type: new Abstract: As large language model (LLM) agents increasingly undertake digital work, reliable frameworks are needed to evaluate their real-world competence, adaptability, and capacity for human collaboration. Existing benchmarks remain largely static, synthetic, or domain-limited, providing limited insight into how agents perform in dynamic, economically meaningful environments. We introduce UpBench, a dynamically evolving benchmark grounded in real jobs drawn from the global Upwork labor marketplace. Each task corresponds to a verified client transaction, anchoring evaluation in genuine work activity and financial outcomes. UpBench employs a rubric-based evaluation framework, in which expert freelancers decompose each job into detailed, verifiable acceptance criteria and assess AI submissions with per-criterion feedback. This structure enables fine-grained analysis of model strengths, weaknesses, and instruction-following fidelity beyond binary pass/fail metrics. Human expertise is integrated throughout the data pipeline (from job curation and rubric construction to evaluation) ensuring fidelity to real professional standards and supporting research on human-AI collaboration. By regularly refreshing tasks to reflect the evolving nature of online work, UpBench provides a scalable, human-centered foundation for evaluating agentic systems in authentic labor-market contexts, offering a path toward a collaborative framework, where AI amplifies human capability through partnership rather than replacement.

arXiv:2511.12378v1 Announce Type: new Abstract: Autonomous agents operating in sequential decision-making tasks under uncertainty can benefit from external action suggestions, which provide valuable guidance but inherently vary in reliability. Existing methods for incorporating such advice typically assume static and known suggester quality parameters, limiting practical deployment. We introduce a framework that dynamically learns and adapts to varying suggester reliability in partially observable environments. First, we integrate suggester quality directly into the agent's belief representation, enabling agents to infer and adjust their reliance on suggestions through Bayesian inference over suggester types. Second, we introduce an explicit ``ask'' action allowing agents to strategically request suggestions at critical moments, balancing informational gains against acquisition costs. Experimental evaluation demonstrates robust performance across varying suggester qualities, adaptation to changing reliability, and strategic management of suggestion requests. This work provides a foundation for adaptive human-agent collaboration by addressing suggestion uncertainty in uncertain environments.

arXiv:2511.12439v1 Announce Type: new Abstract: Online health resources and large language models (LLMs) are increasingly used as a first point of contact for medical decision-making, yet their reliability in healthcare remains limited by low accuracy, lack of transparency, and susceptibility to unverified information. We introduce a proof-of-concept conversational self-triage system that guides LLMs with 100 clinically validated flowcharts from the American Medical Association, providing a structured and auditable framework for patient decision support. The system leverages a multi-agent framework consisting of a retrieval agent, a decision agent, and a chat agent to identify the most relevant flowchart, interpret patient responses, and deliver personalized, patient-friendly recommendations, respectively. Performance was evaluated at scale using synthetic datasets of simulated conversations. The system achieved 95.29% top-3 accuracy in flowchart retrieval (N=2,000) and 99.10% accuracy in flowchart navigation across varied conversational styles and conditions (N=37,200). By combining the flexibility of free-text interaction with the rigor of standardized clinical protocols, this approach demonstrates the feasibility of transparent, accurate, and generalizable AI-assisted self-triage, with potential to support informed patient decision-making while improving healthcare resource utilization.