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Normal view

On the public dissemination and open sourcing of ultrasound resources, datasets and deep learning models

npj Digital Medicine, Published online: 24 November 2025; doi:10.1038/s41746-025-02162-4

On the public dissemination and open sourcing of ultrasound resources, datasets and deep learning models

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

Nature, Published online: 16 November 2022; doi:10.1038/s41586-022-05435-0

Spatial profiling and single-cell RNA sequencing are used to map the spatial distribution of the microbiota within human tumours, revealing how intratumoral microbial communities contribute to tumour heterogeneity and cancer progression.

The co-evolution of the genome and epigenome in colorectal cancer

Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05202-1

A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

Phenotypic plasticity and genetic control in colorectal cancer evolution

Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05311-x

Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

Researcher perspectives on ethics considerations in epigenetics: an international survey

Over the past decade, bioethicists, legal scholars and social scientists have started to investigate the potential implications of epigenetic research and technologies on medicine and society. There is growing...
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