Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09398-wA study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study metastasis trajectories.

Nature, Published online: 12 April 2023; doi:10.1038/s41586-023-05706-4Computational and machine-learning approaches that integrate genomic and transcriptomic variation from paired primary and metastatic non-small cell lung cancer samples from the TRACERx cohort reveal the role of transcriptional events in tumour evolution.