arXiv:2512.11509v1 Announce Type: cross Abstract: Large Language Models (LLMs) exhibit remarkable capabilities in natural language understanding and reasoning, but suffer from hallucination: the generation of factually incorrect content. While numerous methods have been developed to reduce hallucinations, their impact on creative generations remains unexplored. This gap is particularly critical for AI-assisted scientific discovery, which requires both factual accuracy and creative hypothesis generation. We investigate how three hallucination-reduction techniques: Chain of Verification (CoVe), Decoding by Contrasting Layers (DoLa), and Retrieval-Augmented Generation (RAG), affect creativity in LLMs. Evaluating multiple model families (LLaMA, Qwen, Mistral) at varying scales (1B - 70B parameters) on two creativity benchmarks (NeoCoder and CS4), we find that these methods have opposing effects on divergent creativity. CoVe enhances divergent thinking, DoLa suppresses it, and RAG shows minimal impact. Our findings provide guidance for selecting appropriate hallucination-reduction methods in scientific applications, where the balance between factual accuracy and creative exploration is crucial.

arXiv:2512.11661v1 Announce Type: cross Abstract: Large Language Models (LLMs) are increasingly embedded in academic writing practices. Although numerous studies have explored how researchers employ these tools for scientific writing, their concrete implementation, limitations, and design challenges within the literature review process remain underexplored. In this paper, we report a user study with researchers across multiple disciplines to characterize current practices, benefits, and \textit{pain points} in using LLMs to investigate related work. We identified three recurring gaps: (i) lack of trust in outputs, (ii) persistent verification burden, and (iii) requiring multiple tools. This motivates our proposal of six design goals and a high-level framework that operationalizes them through improved related papers visualization, verification at every step, and human-feedback alignment with generation-guided explanations. Overall, by grounding our work in the practical, day-to-day needs of researchers, we designed a framework that addresses these limitations and models real-world LLM-assisted writing, advancing trust through verifiable actions and fostering practical collaboration between researchers and AI systems.

arXiv:2409.13115v2 Announce Type: replace-cross Abstract: Integrating artificial intelligence (AI) with healthcare data is rapidly transforming medical diagnostics and driving progress toward precision medicine. However, effectively leveraging multimodal data, particularly digital pathology whole slide images (WSIs) and genomic sequencing, remains a significant challenge due to the intrinsic heterogeneity of these modalities and the need for scalable and interpretable frameworks. Existing diagnostic models typically operate on unimodal data, overlooking critical cross-modal interactions that can yield richer clinical insights. We introduce MarbliX (Multimodal Association and Retrieval with Binary Latent Indexed matriX), a self-supervised framework that learns to embed WSIs and immunogenomic profiles into compact, scalable binary codes, termed ``monogram.'' By optimizing a triplet contrastive objective across modalities, MarbliX captures high-resolution patient similarity in a unified latent space, enabling efficient retrieval of clinically relevant cases and facilitating case-based reasoning. \textcolor{black}{In lung cancer, MarbliX achieves 85-89\% across all evaluation metrics, outperforming histopathology (69-71\%) and immunogenomics (73-76\%). In kidney cancer, real-valued monograms yield the strongest performance (F1: 80-83\%, Accuracy: 87-90\%), with binary monograms slightly lower (F1: 78-82\%).

arXiv:2503.05860v3 Announce Type: replace-cross Abstract: Benchmarks are essential for unified evaluation and reproducibility. The rapid rise of Artificial Intelligence for Software Engineering (AI4SE) has produced numerous benchmarks for tasks such as code generation and bug repair. However, this proliferation has led to major challenges: (1) fragmented knowledge across tasks, (2) difficulty in selecting contextually relevant benchmarks, (3) lack of standardization in benchmark creation, and (4) flaws that limit utility. Addressing these requires a dual approach: systematically mapping existing benchmarks for informed selection and defining unified guidelines for robust, adaptable benchmark development. We conduct a review of 247 studies, identifying 273 AI4SE benchmarks since 2014. We categorize them, analyze limitations, and expose gaps in current practices. Building on these insights, we introduce BenchScout, an extensible semantic search tool for locating suitable benchmarks. BenchScout employs automated clustering with contextual embeddings of benchmark-related studies, followed by dimensionality reduction. In a user study with 22 participants, BenchScout achieved usability, effectiveness, and intuitiveness scores of 4.5, 4.0, and 4.1 out of 5. To improve benchmarking standards, we propose BenchFrame, a unified framework for enhancing benchmark quality. Applying BenchFrame to HumanEval yielded HumanEvalNext, featuring corrected errors, improved language conversion, higher test coverage, and greater difficulty. Evaluating 10 state-of-the-art code models on HumanEval, HumanEvalPlus, and HumanEvalNext revealed average pass-at-1 drops of 31.22% and 19.94%, respectively, underscoring the need for continuous benchmark refinement. We further examine BenchFrame's scalability through an agentic pipeline and confirm its generalizability on the MBPP dataset. All review data, user study materials, and enhanced benchmarks are publicly released.

arXiv:2509.12421v2 Announce Type: replace-cross Abstract: The rapid adoption of foundation models (e.g., large language models) has given rise to promptware, i.e., software built using natural language prompts. Effective management of prompts, such as organization and quality assurance, is essential yet challenging. In this study, we perform an empirical analysis of 24,800 open-source prompts from 92 GitHub repositories to investigate prompt management practices and quality attributes. Our findings reveal critical challenges such as considerable inconsistencies in prompt formatting, substantial internal and external prompt duplication, and frequent readability and spelling issues. Based on these findings, we provide actionable recommendations for developers to enhance the usability and maintainability of open-source prompts within the rapidly evolving promptware ecosystem.

arXiv:2512.10041v2 Announce Type: replace-cross Abstract: Modern deep learning methods have achieved impressive results across tasks from disease classification, estimating continuous biomarkers, to generating realistic medical images. Most of these approaches are trained to model conditional distributions defined by a specific predictive direction with a specific set of input variables. We introduce MetaVoxel, a generative joint diffusion modeling framework that models the joint distribution over imaging data and clinical metadata by learning a single diffusion process spanning all variables. By capturing the joint distribution, MetaVoxel unifies tasks that traditionally require separate conditional models and supports flexible zero-shot inference using arbitrary subsets of inputs without task-specific retraining. Using more than 10,000 T1-weighted MRI scans paired with clinical metadata from nine datasets, we show that a single MetaVoxel model can perform image generation, age estimation, and sex prediction, achieving performance comparable to established task-specific baselines. Additional experiments highlight its capabilities for flexible inference. Together, these findings demonstrate that joint multimodal diffusion offers a promising direction for unifying medical AI models and enabling broader clinical applicability.

Senescent “zombie” cells are linked to aging and multiple diseases, but spotting them in living tissue has been notoriously difficult. Researchers at Mayo Clinic have now taken an inventive leap by using aptamers—tiny, shape-shifting DNA molecules—to selectively tag these elusive cells. The project began as an offbeat conversation between two graduate students and quickly evolved into a collaborative, cross-lab effort that uncovered aptamers capable of binding to unique surface proteins on senescent cells.

Health Policy

This cross-sectional study examines the association between buy now, pay later loans and probable depression, anxiety, and posttraumatic stress.

Background: Computer perception (CP) technologies hold significant promise for advancing precision mental health care systems, given their ability to leverage algorithmic analysis of continuous, passive sensing data from wearables and smartphones (eg, behavioral activity, geolocation, vocal features, and ambient environmental data) to infer clinically meaningful behavioral and physiological states. However, successful implementation critically depends on cultivating well-founded stakeholder trust. Objective: This study aims to investigate, across adolescents, caregivers, clinicians, and developers, the contingencies under which CP technologies are deemed trustworthy in health care. Methods: We conducted 80 semistructured interviews with a purposive sample of adolescents (n=20) diagnosed with autism, Tourette syndrome, anxiety, obsessive-compulsive disorder, or attention-deficit/hyperactivity disorder and their caregivers (n=20); practicing clinicians across psychiatry, psychology, and pediatrics (n=20); and CP system developers (n=20). Interview transcripts were coded by 2 independent coders and analyzed using multistage, inductive thematic content analysis to identify prominent themes. Results: Across stakeholder groups, 5 core criteria emerged as prerequisites for trust in CP outputs: (1) epistemic alignment—consistency between system outputs, personal experience, and existing diagnostic frameworks; (2) demonstrable rigor—training on representative data and validation in real-world contexts; (3) explainability—transparent communication of input variables, thresholds, and decision logic; (4) sensitivity to complexity—the capacity to accommodate heterogeneity and comorbidity in symptom expression; and (5) a nonsubstitutive role—technologies must augment, rather than supplant, clinical judgment. A novel and cautionary finding was that epistemic alignment—whether outputs affirmed participants’ preexisting beliefs, diagnostic expectations, or internal states—was a dominant factor in determining whether the tool was perceived as trustworthy. Participants also expressed relational trust, placing confidence in CP systems based on endorsements from respected peers, academic institutions, or regulatory agencies. However, both trust strategies raise significant concerns: confirmation bias may lead users to overvalue outputs that align with their assumptions, while surrogate trust may be misapplied in the absence of robust performance validation. Conclusions: This study advances empirical understanding of how trust is formed and calibrated around artificial intelligence–based CP technologies. While trust is commonly framed as a function of technical performance, our findings show that it is deeply shaped by cognitive heuristics, social relationships, and alignment with entrenched epistemologies. These dynamics can facilitate intuitive verification but may also constrain the transformative potential of CP systems by reinforcing existing beliefs. To address this, we recommend a dual strategy: (1) embedding CP tools within institutional frameworks that uphold rigorous validation, ethical oversight, and transparent design; and (2) providing clinicians with training and interface designs that support critical appraisal and minimize susceptibility to cognitive bias. Recalibrating trust to reflect actual system capacities—rather than familiarity or endorsement—is essential for ethically sound and clinically meaningful integration of CP technologies.

npj Digital Medicine, Published online: 13 December 2025; doi:10.1038/s41746-025-02157-1

Legal implications of AI standard of care integration on patients’ informed consent: lessons from surgery

Generative AI’s experimental phase is concluding, making way for truly autonomous systems in 2026 that act rather than merely summarise.

2026 will lose the focus on model parameters and be about agency, energy efficiency, and the ability to navigate complex industrial environments. The next twelve months represent a departure from chatbots toward autonomous systems executing workflows with minimal oversight; forcing organisations to rethink infrastructure, governance, and talent management.

Autonomous AI systems take the wheel

Hanen Garcia, Chief Architect for Telecommunications at Red Hat, argues that while 2025 was defined by experimentation, the coming year marks a “decisive pivot towards agentic AI, autonomous software entities capable of reasoning, planning, and executing complex workflows without constant human intervention.”

Telecoms and heavy industry are the proving grounds. Garcia points to a trajectory toward autonomous network operations (ANO), moving beyond simple automation to self-configuring and self-healing systems. The business goal is to reverse commoditisation by “prioritising intelligence over pure infrastructure” and reduce operating expenditures.

Technologically, service providers are deploying multiagent systems (MAS). Rather than relying on a single model, these allow distinct agents to collaborate on multi-step tasks, handling complex interactions autonomously. However, increased autonomy introduces new threats.

Emmet King, Founding Partner of J12 Ventures, warns that “as AI agents gain the ability to autonomously execute tasks, hidden instructions embedded in images and workflows become potential attack vectors.” Security priorities must therefore shift from endpoint protection to “governing and auditing autonomous AI actions.”

As organisations scale these autonomous AI workloads, they hit a physical wall: power.

King argues energy availability, rather than model access, will determine which startups scale. “Compute scarcity is now a function of grid capacity,” King states, suggesting energy policy will become the de facto AI policy in Europe.

KPIs must adapt. Sergio Gago, CTO at Cloudera, predicts enterprises will prioritise energy efficiency as a primary metric. “The new competitive edge won’t come from the largest models, but from the most intelligent, efficient use of resources.”

Horizontal copilots lacking domain expertise or proprietary data will fail ROI tests as buyers measure real productivity. The “clearest enterprise ROI” will emerge from manufacturing, logistics, and advanced engineering—sectors where AI integrates into high-value workflows rather than consumer-facing interfaces.

AI ends the static app in 2026

Software consumption is changing too. Chris Royles, Field CTO for EMEA at Cloudera, suggests the traditional concept of an “app” is becoming fluid. “In 2026, AI will start to radically change the way we think about apps, how they function and how they’re built.”

Users will soon request temporary modules generated by code and a prompt, effectively replacing dedicated applications. “Once that function has served its purpose, it closes,” Royles explains, noting these “disposable” apps can be built and rebuilt in seconds.

Rigorous governance is required here; organisations need visibility into the reasoning processes used to create these modules to ensure errors are corrected safely.

Data storage faces a similar reckoning, especially as AI becomes more autonomous. Wim Stoop, Director of Product Marketing at Cloudera, believes the era of “digital hoarding” is ending as storage capacity hits its limit.

“AI-generated data will become disposable, created and refreshed on demand rather than stored indefinitely,” Stoop predicts. Verified, human-generated data will rise in value while synthetic content is discarded.

Specialist AI governance agents will pick up the slack. These “digital colleagues” will continuously monitor and secure data, allowing humans to “govern the governance” rather than enforcing individual rules. For example, a security agent could automatically adjust access permissions as new data enters the environment without human intervention.

Sovereignty and the human element

Sovereignty remains a pressing concern for European IT. Red Hat’s survey data indicates 92 percent of IT and AI leaders in EMEA view enterprise open-source software as vital for achieving sovereignty. Providers will leverage existing data centre footprints to offer sovereign AI solutions, ensuring data remains within specific jurisdictions to meet compliance demands.

Emmet King, Founding Partner of J12 Ventures, adds that competitive advantage is moving from owning models to “controlling training pipelines and energy supply,” with open-source advancements allowing more actors to run frontier-scale workloads.

Workforce integration is becoming personal. Nick Blasi, Co-Founder of Personos, argues tools ignoring human nuance – tone, temperament, and personality – will soon feel obsolete. By 2026, Blasi predicts “half of workplace conflict will be flagged by AI before managers know it exists.”

These systems will focus on “communication, influence, trust, motivation, and conflict resolution,” Blasi suggests, adding that personality science will become the “operating system” for the next generation of autonomous AI, offering grounded understanding of human individuality rather than generic recommendations.

The era of the “thin wrapper” is over. Buyers are now measuring real productivity, exposing tools built on hype rather than proprietary data. For the enterprise, competitive advantage will no longer come from renting access to a model, but from controlling the training pipelines and energy supply that power it.

See also: BBVA embeds AI into banking workflows using ChatGPT Enterprise

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Nature, Published online: 12 December 2025; doi:10.1038/d41586-025-04048-7

The United States tops the remaining areas in an assessment of 74 technologies.

Researchers used AI to pinpoint a little-known monkeypox protein that provokes strong protective antibodies. When the team tested this protein as a vaccine ingredient in mice, it produced a potent immune response. The discovery could lead to simpler, more effective mpox vaccines and therapies. It may also help guide future efforts against smallpox.

Nature Medicine, Published online: 12 December 2025; doi:10.1038/s41591-025-04148-x

To improve early detection, cancer screening studies need to evolve and integrate multimodal data in the identification of high-risk individuals.

Trump signed an AI executive order targeting state laws and promising one national rulebook. Critics warn it could trigger court battles and prolong uncertainty for startups while Congress debates federal rules.