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cs.AI, q-bio.NC updates on arXiv.org
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EduAgentQG: A Multi-Agent Workflow Framework for Personalized Question Generation
arXiv:2511.11635v1 Announce Type: cross Abstract: High-quality personalized question banks are crucial for supporting adaptive learning and individualized assessment. Manually designing questions is time-consuming and often fails to meet diverse learning needs, making automated question generation a crucial approach to reduce teachers' workload and improve the scalability of educational resources. However, most existing question generation methods rely on single-agent or rule-based pipelines, w
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Pan-cancer analysis uncovered the prognostic and therapeutic value of disulfidptosis
NPJ Precis Oncol. 2025 Feb 24;9(1):50. doi: 10.1038/s41698-025-00834-8.ABSTRACTDisulfidptosis, a newly discovered cell death mode distinct from other programmed cell death in lung and kidney cancer cells, is defined as extensive disulfide bonds to actin cytoskeleton proteins, leading to actin contraction and cytoskeletal disruption cell death. New cell death pattern discoveries often drive advances in tumor research. Therefore, the present study attempted to decipher the manifestation and import
Pan-cancer analysis uncovered the prognostic and therapeutic value of disulfidptosis
NPJ Precis Oncol. 2025 Feb 24;9(1):50. doi: 10.1038/s41698-025-00834-8.
ABSTRACT
Disulfidptosis, a newly discovered cell death mode distinct from other programmed cell death in lung and kidney cancer cells, is defined as extensive disulfide bonds to actin cytoskeleton proteins, leading to actin contraction and cytoskeletal disruption cell death. New cell death pattern discoveries often drive advances in tumor research. Therefore, the present study attempted to decipher the manifestation and importance of disulfidptosis in pan-cancer. Combining Clinical specimen immunofluorescence staining, single-cell analyses, and spatial transcriptome analyses, we demonstrated the manifestation of disulfidptosis in pan-cancer. Multi-omics analysis has revealed that genomic variants and DNA methylation in DRGs can affect the prognosis of patients with pan-cancer. The nomogram based on the DRGs Score model could accurately predict the prognosis of patients with pan-cancer. PF-562271, EHT-1864, and IPA-3 are potential therapeutic agents targeting disulfidptosis. Collectively, this study deciphered for the first time the importance of disulfidptosis for pan-cancer and developed the DRGs Score model that can assist clinicians in accurately predicting the prognosis and guiding individualized treatment of pan-cancer patients.
PMID:39994355 | DOI:10.1038/s41698-025-00834-8