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FedSEA-LLaMA: A Secure, Efficient and Adaptive Federated Splitting Framework for Large Language Models

arXiv:2505.15683v4 Announce Type: replace-cross Abstract: Private data holds promise for improving LLMs due to its high quality, but its scattered distribution across data silos and the high computational demands of LLMs limit their deployment in federated environments. To address this, the transformer-based federated split models are proposed, which offload most model parameters to the server (or distributed clients) while retaining only a small portion on the client to ensure data privacy. Despite this design, they still face three challenges: 1) Peer-to-peer key encryption struggles to secure transmitted vectors effectively; 2) The auto-regressive nature of LLMs means that federated split learning can only train and infer sequentially, causing high communication overhead; 3) Fixed partition points lack adaptability to downstream tasks. In this paper, we introduce FedSEA-LLaMA, a Secure, Efficient, and Adaptive Federated splitting framework based on LLaMA2. First, we inject Gaussian noise into forward-pass hidden states to enable secure end-to-end vector transmission. Second, we employ attention-mask compression and KV cache collaboration to reduce communication costs, accelerating training and inference. Third, we allow users to dynamically adjust the partition points for input/output blocks based on specific task requirements. Experiments on natural language understanding, summarization, and conversational QA tasks show that FedSEA-LLaMA maintains performance comparable to centralized LLaMA2 and achieves up to 8x speedups in training and inference. Further analysis of privacy attacks and different partition points also demonstrates the effectiveness of FedSEA-LLaMA in security and adaptability.

Digital Twin based Automatic Reconfiguration of Robotic Systems in Smart Environments

arXiv:2511.00094v2 Announce Type: replace-cross Abstract: Robotic systems have become integral to smart environments, enabling applications ranging from urban surveillance and automated agriculture to industrial automation. However, their effective operation in dynamic settings - such as smart cities and precision farming - is challenged by continuously evolving topographies and environmental conditions. Traditional control systems often struggle to adapt quickly, leading to inefficiencies or operational failures. To address this limitation, we propose a novel framework for autonomous and dynamic reconfiguration of robotic controllers using Digital Twin technology. Our approach leverages a virtual replica of the robot's operational environment to simulate and optimize movement trajectories in response to real-world changes. By recalculating paths and control parameters in the Digital Twin and deploying the updated code to the physical robot, our method ensures rapid and reliable adaptation without manual intervention. This work advances the integration of Digital Twins in robotics, offering a scalable solution for enhancing autonomy in smart, dynamic environments.

Application and research progress of artificial intelligence in the diagnosis and treatment of rare lung diseases

Zhonghua Jie He He Hu Xi Za Zhi. 2026 Jan 12;49(1):78-83. doi: 10.3760/cma.j.cn112147-20250728-00445.

ABSTRACT

Rare lung diseases are a group of diseases characterized by significant clinical heterogeneity, challenging diagnosis and treatment processes, and diverse underlying causes. Due to their uncommon symptoms and limited awareness among healthcare providers, these diseases are frequently misdiagnosed or diagnosed too late, resulting in poor patient outcomes and placing a significant healthcare burden on the healthcare system. However, in recent years, the rapid advancements in artificial intelligence (AI) technology within the medical field have created new opportunities for early identification, accurate diagnosis, and personalized management of these diseases. A variety of AI techniques, ranging from traditional machine learning to more recent methods such as deep learning, reinforcement learning, and transfer learning, have been employed in areas such as clinical decision support, radiomics, omics data analysis, and the prediction of treatment responses for rare lung diseases. This article systematically reviews the latest research progress of AI applications in idiopathic pulmonary fibrosis, cystic fibrosis, idiopathic pulmonary arterial hypertension, and other rare lung diseases. It also emphasizes AI's potential benefits in disease classification, treatment evaluation, and prognosis prediction through illustrative research examples.

PMID:41483922 | DOI:10.3760/cma.j.cn112147-20250728-00445

Artificial intelligence in hepatopathy diagnosis and treatment: Big data analytics, deep learning, and clinical prediction models

World J Gastroenterol. 2025 Dec 14;31(46):111176. doi: 10.3748/wjg.v31.i46.111176.

ABSTRACT

Artificial intelligence (AI) is rapidly transforming the landscape of hepatology by enabling automated data interpretation, early disease detection, and individualized treatment strategies. Chronic liver diseases, including non-alcoholic fatty liver disease, cirrhosis, and hepatocellular carcinoma, often progress silently and pose diagnostic challenges due to reliance on invasive biopsies and operator-dependent imaging. This review explores the integration of AI across key domains such as big data analytics, deep learning-based image analysis, histopathological interpretation, biomarker discovery, and clinical prediction modeling. AI algorithms have demonstrated high accuracy in liver fibrosis staging, hepatocellular carcinoma detection, and non-alcoholic fatty liver disease risk stratification, while also enhancing survival prediction and treatment response assessment. For instance, convolutional neural networks trained on portal venous-phase computed tomography have achieved area under the curves up to 0.92 for significant fibrosis (F2-F4) and 0.89 for advanced fibrosis, with magnetic resonance imaging-based models reporting comparable performance. Advanced methodologies such as federated learning preserve patient privacy during cross-center model training, and explainable AI techniques promote transparency and clinician trust. Despite these advancements, clinical adoption remains limited by challenges including data heterogeneity, algorithmic bias, regulatory uncertainty, and lack of real-time integration into electronic health records. Looking forward, the convergence of multi-omics, imaging, and clinical data through interpretable and validated AI frameworks holds great promise for precision liver care. Continued efforts in model standardization, ethical oversight, and clinician-centered deployment will be essential to realize the full potential of AI in hepatopathy diagnosis and treatment.

PMID:41479639 | PMC:PMC12754151 | DOI:10.3748/wjg.v31.i46.111176

A clinically validated 3D deep learning approach for quantifying vascular invasion in pancreatic cancer

npj Digital Medicine, Published online: 31 December 2025; doi:10.1038/s41746-025-02260-3

A clinically validated 3D deep learning approach for quantifying vascular invasion in pancreatic cancer
  • ✇STAT
  • Opinion: New medical technology presents hospitals with a prisoner’s dilemma James L. Whiteside and Dmitry Tumin
    In 2026, Medtronic plans to launch a new robot to compete with a legacy market leader. This new robot is reportedly cheaper both in startup and sustained costs. That’s a welcome direction for any new medical technology, but it ignores a problem that hospitals, especially rural ones, face relating to technology and physician training. Sometimes, rational decisions made in isolation lead to irrational outcomes for everyone involved. This is the lesson of the prisoner’s dilemma, a classic game t
     

Opinion: New medical technology presents hospitals with a prisoner’s dilemma

2 January 2026 at 17:30

In 2026, Medtronic plans to launch a new robot to compete with a legacy market leader. This new robot is reportedly cheaper both in startup and sustained costs. That’s a welcome direction for any new medical technology, but it ignores a problem that hospitals, especially rural ones, face relating to technology and physician training.

Sometimes, rational decisions made in isolation lead to irrational outcomes for everyone involved. This is the lesson of the prisoner’s dilemma, a classic game theory puzzle demonstrating how cooperation and self-interest often clash. In the puzzle, two prisoners are each offered a deal: Inform on the other and go free, or stay silent and face a lighter sentence together. Fearing betrayal, both inform and both lose.

Read the rest…

© PASCAL POCHARD-CASABIANCA/AFP via Getty Images

  • ✇STAT
  • STAT+: Who will pay for AI in health care? 3 trends to watch in 2026 Katie Palmer
    The health care industry is gearing up for a battle over whether and how clinical artificial intelligence should get paid for.  As of the end of September, the Food and Drug Administration has authorized 1,357 AI-enabled medical devices. But very few of those tools are actively paid for by insurers.  Some health policy experts and clinicians don’t see that as a problem. Continue to STAT+ to read the full story…
     

STAT+: Who will pay for AI in health care? 3 trends to watch in 2026

2 January 2026 at 17:30

The health care industry is gearing up for a battle over whether and how clinical artificial intelligence should get paid for. 

As of the end of September, the Food and Drug Administration has authorized 1,357 AI-enabled medical devices. But very few of those tools are actively paid for by insurers. 

Some health policy experts and clinicians don’t see that as a problem.

Continue to STAT+ to read the full story…

© Christine Kao/STAT

Autologous multiantigen-targeted T cell therapy for pancreatic cancer: a phase 1/2 trial

Nature Medicine, Published online: 02 January 2026; doi:10.1038/s41591-025-04043-5

Results of the phase 1/2 TACTOPS trial show that autologous T cell therapy targeting PRAME, SSX2, MAGEA4, Survivin and NY-ESO-1 in patients with pancreatic ductal adenocarcinoma is feasible and safe, and leads to encouraging clinical responses and evidence of antigen spreading in responders.

Artificial Intelligence Applications in the Diagnosis, Treatment, and Prognosis of Hepatocellular Carcinoma

Gut Liver. 2025 Dec 31. doi: 10.5009/gnl250268. Online ahead of print.

ABSTRACT

The global burden of hepatocellular carcinoma (HCC) has shifted from viral to nonviral etiologies. However, successful antiviral therapy does not fully eliminate the risk of HCC, underscoring the demand for more effective surveillance strategies. Current screening methods, such as semiannual ultrasonography and the measurement of α-fetoprotein levels, offer suboptimal sensitivity for early detection. A cost-effective, reliable surveillance approach remains an unmet need. The Barcelona Clinic Liver Cancer staging system provides a framework to guide HCC therapy; yet, some gray zone exists, particularly for patients with intermediate-stage disease. Although tyrosine kinase inhibitors and immunotherapies have transformed the therapeutic landscape, their efficacies vary among patients, highlighting the necessity for personalized treatment strategies. In response to these challenges, artificial intelligence (AI) approaches have emerged as transformative tools in healthcare. By processing complex, nonlinear relationships and uncovering hidden patterns in clinical data, AI methods offer capabilities beyond those of traditional statistical methods. Furthermore, AI-driven multi-omics analysis holds promise for identifying novel biomarkers, thereby advancing precision medicine for HCC patients. This review introduces the potential of AI applications in enhancing the diagnosis, treatment, and prognosis of HCC.

PMID:41472345 | DOI:10.5009/gnl250268

Multi-Omics and Functional Analysis of BFSP1 as a Prognostic and Therapeutic Target in Liver Hepatocellular Carcinoma

Medicina (Kaunas). 2025 Dec 11;61(12):2196. doi: 10.3390/medicina61122196.

ABSTRACT

Background and Objectives: Although beaded filament structural protein 1 (BFSP1) may be involved in oncogenic mechanisms, its clinical relevance and functional role in liver hepatocellular carcinoma (LIHC) remain unclear. This study examined the prognostic significance, regulatory mechanisms, and potential therapeutic implications of BFSP1 in LIHC. Materials and Methods: Comprehensive bioinformatics analysis was performed across multiple platforms using datasets derived from The Cancer Genome Atlas. Differential gene expression, DNA methylation, copy number variation, immune cell infiltration, drug sensitivity, and co-expression networks were systematically examined. Functional enrichment analyses of protein-protein and gene-gene interaction networks were conducted using STRING and GeneMANIA. Additionally, short interfering RNA-mediated knockdown and wound-healing assays were performed in HepG2 cells to evaluate BFSP1 function in vitro. Results: The results showed that BFSP1 mRNA expression was significantly upregulated in tissues from LIHC patients. Elevated BFSP1 levels were associated with poorer prognostic patterns, which were further supported by detailed clinicopathological subgroup analyses. Furthermore, BFSP1 expression was correlated with promoter hypomethylation and associated with patterns of tumor-infiltrating immune cells, including specific immune cell subtypes such as M1 and M2 macrophages. Integrative analyses revealed strong associations between BFSP1 and drug sensitivity, as well as a regulatory network encompassing genes involved in the cell cycle, DNA repair, and metabolic processes. Functional knockdown of BFSP1 significantly reduced HepG2 cell migration in vitro, as assessed by wound healing assay, with decreased wound closure at 24 h (11.0% vs. 16.5%) and 48 h (7.4% vs. 12.5%) compared with the control (p < 0.05, n = 6 biological replicates). Conclusions: In conclusion, these findings suggest that BFSP1 functions as a multifaceted prognostic biomarker and a potential therapeutic target for LIHC.

PMID:41470198 | PMC:PMC12735119 | DOI:10.3390/medicina61122196

Artificial Intelligence Applications in the Diagnosis, Treatment, and Prognosis of Hepatocellular Carcinoma

Gut Liver. 2025 Dec 31. doi: 10.5009/gnl250268. Online ahead of print.

ABSTRACT

The global burden of hepatocellular carcinoma (HCC) has shifted from viral to nonviral etiologies. However, successful antiviral therapy does not fully eliminate the risk of HCC, underscoring the demand for more effective surveillance strategies. Current screening methods, such as semiannual ultrasonography and the measurement of α-fetoprotein levels, offer suboptimal sensitivity for early detection. A cost-effective, reliable surveillance approach remains an unmet need. The Barcelona Clinic Liver Cancer staging system provides a framework to guide HCC therapy; yet, some gray zone exists, particularly for patients with intermediate-stage disease. Although tyrosine kinase inhibitors and immunotherapies have transformed the therapeutic landscape, their efficacies vary among patients, highlighting the necessity for personalized treatment strategies. In response to these challenges, artificial intelligence (AI) approaches have emerged as transformative tools in healthcare. By processing complex, nonlinear relationships and uncovering hidden patterns in clinical data, AI methods offer capabilities beyond those of traditional statistical methods. Furthermore, AI-driven multi-omics analysis holds promise for identifying novel biomarkers, thereby advancing precision medicine for HCC patients. This review introduces the potential of AI applications in enhancing the diagnosis, treatment, and prognosis of HCC.

PMID:41472345 | DOI:10.5009/gnl250268

Multi-Omics and Functional Analysis of BFSP1 as a Prognostic and Therapeutic Target in Liver Hepatocellular Carcinoma

31 December 2025 at 19:00

Medicina (Kaunas). 2025 Dec 11;61(12):2196. doi: 10.3390/medicina61122196.

ABSTRACT

Background and Objectives: Although beaded filament structural protein 1 (BFSP1) may be involved in oncogenic mechanisms, its clinical relevance and functional role in liver hepatocellular carcinoma (LIHC) remain unclear. This study examined the prognostic significance, regulatory mechanisms, and potential therapeutic implications of BFSP1 in LIHC. Materials and Methods: Comprehensive bioinformatics analysis was performed across multiple platforms using datasets derived from The Cancer Genome Atlas. Differential gene expression, DNA methylation, copy number variation, immune cell infiltration, drug sensitivity, and co-expression networks were systematically examined. Functional enrichment analyses of protein-protein and gene-gene interaction networks were conducted using STRING and GeneMANIA. Additionally, short interfering RNA-mediated knockdown and wound-healing assays were performed in HepG2 cells to evaluate BFSP1 function in vitro. Results: The results showed that BFSP1 mRNA expression was significantly upregulated in tissues from LIHC patients. Elevated BFSP1 levels were associated with poorer prognostic patterns, which were further supported by detailed clinicopathological subgroup analyses. Furthermore, BFSP1 expression was correlated with promoter hypomethylation and associated with patterns of tumor-infiltrating immune cells, including specific immune cell subtypes such as M1 and M2 macrophages. Integrative analyses revealed strong associations between BFSP1 and drug sensitivity, as well as a regulatory network encompassing genes involved in the cell cycle, DNA repair, and metabolic processes. Functional knockdown of BFSP1 significantly reduced HepG2 cell migration in vitro, as assessed by wound healing assay, with decreased wound closure at 24 h (11.0% vs. 16.5%) and 48 h (7.4% vs. 12.5%) compared with the control (p < 0.05, n = 6 biological replicates). Conclusions: In conclusion, these findings suggest that BFSP1 functions as a multifaceted prognostic biomarker and a potential therapeutic target for LIHC.

PMID:41470198 | PMC:PMC12735119 | DOI:10.3390/medicina61122196

Effectiveness of Digital Interventions for Low-Income, Food-Insecure Populations: Natural Language Processing Study of WIC Smartphone App User Reviews, 2013-2024

Background: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a federal nutrition assistance program for low-income, food-insecure mothers and young children in the United States. Despite its intended goals, many eligible individuals forgo WIC benefits, in part due to administrative burden – defined as the complex, often frustrating processes encountered when navigating public benefits programs. In response, a range of digital interventions and policy waivers were introduced during the COVID-19 pandemic, but their effectiveness in reducing barriers remains unclear. Objective: Drawing from administrative burden theory and human-computer interaction (HCI) research, this study examined user reviews of WIC smartphone applications (WIC Apps) utilized by local agencies. Specifically, it investigated (a) how obstacles to WIC access manifested in daily app use, (b) how user experiences shifted after the onset of the COVID-19 pandemic, and (c) how these changes were associated with app ratings. Methods: An original dataset of user reviews (Nreview = 28,212) was compiled for 26 WIC Apps between 2013 and 2024. Structural topic modeling identified eight key themes, and sentiment was examined with RoBERTa (Robustly Optimized Bidirectional Encoder Representations from Transformers Pretraining Approach). Analyses compared topic prevalence and sentiment distributions before and after COVID-19. Mixed-effects models examined the relationship between topics, sentiment, and app ratings. Results: Technical concerns related to account authentication and login, document upload, and app updates were among the most prevalent themes. These issues were typically expressed with negative sentiment and appeared more frequently in pre-COVID-19 reviews than in post-COVID-19 reviews. Although reliability problems (e.g., outages, maintenance) persisted, post-COVID-19 reviews increasingly emphasized features that facilitated program tracking, shopping and benefit redemption, and general ease of use, which were generally described with positive sentiment. Mixed-effects analyses indicated that the post-COVID-19 topics were significantly associated with higher app ratings (program tracking: B = 0.21, SE = 0.06, P = .001, shopping and redemption: B = 0.18, SE = 0.07, P = .01, ease of use: B = 0.10, SE = 0.05, P = .04), whereas pre-COVID-19 concerns were not associated with ratings (Ps > .05). When sentiment was added to the mixed-effect model, it became the dominant factor: negative sentiment was associated with lower ratings (B = -1.71, SE = 0.03, P .05), suggesting that sentiment contributed to much of the variance previously linked to topics. Conclusions: User-centered digital interventions, such as WIC Apps, have potential to support WIC access and participation.

PIC-SURE: an open-source platform for integrating clinical and genomic data

npj Digital Medicine, Published online: 30 December 2025; doi:10.1038/s41746-025-02284-9

PIC-SURE: an open-source platform for integrating clinical and genomic data

Bidirectional RAG: Safe Self-Improving Retrieval-Augmented Generation Through Multi-Stage Validation

arXiv:2512.22199v1 Announce Type: new Abstract: Retrieval-Augmented Generation RAG systems enhance large language models by grounding responses in external knowledge bases, but conventional RAG architectures operate with static corpora that cannot evolve from user interactions. We introduce Bidirectional RAG, a novel RAG architecture that enables safe corpus expansion through validated write back of high quality generated responses. Our system employs a multi stage acceptance layer combining grounding verification (NLI based entailment, attribution checking, and novelty detection to prevent hallucination pollution while enabling knowledge accumulation. Across four datasets Natural Questions, TriviaQA, HotpotQA, Stack Overflow with three random seeds 12 experiments per system, Bidirectional RAG achieves 40.58% average coverage nearly doubling Standard RAG 20.33% while adding 72% fewer documents than naive write back 140 vs 500. Our work demonstrates that self improving RAG is feasible and safe when governed by rigorous validation, offering a practical path toward RAG systems that learn from deployment.

SciEvalKit: An Open-source Evaluation Toolkit for Scientific General Intelligence

arXiv:2512.22334v1 Announce Type: new Abstract: We introduce SciEvalKit, a unified benchmarking toolkit designed to evaluate AI models for science across a broad range of scientific disciplines and task capabilities. Unlike general-purpose evaluation platforms, SciEvalKit focuses on the core competencies of scientific intelligence, including Scientific Multimodal Perception, Scientific Multimodal Reasoning, Scientific Multimodal Understanding, Scientific Symbolic Reasoning, Scientific Code Generation, Science Hypothesis Generation and Scientific Knowledge Understanding. It supports six major scientific domains, spanning from physics and chemistry to astronomy and materials science. SciEvalKit builds a foundation of expert-grade scientific benchmarks, curated from real-world, domain-specific datasets, ensuring that tasks reflect authentic scientific challenges. The toolkit features a flexible, extensible evaluation pipeline that enables batch evaluation across models and datasets, supports custom model and dataset integration, and provides transparent, reproducible, and comparable results. By bridging capability-based evaluation and disciplinary diversity, SciEvalKit offers a standardized yet customizable infrastructure to benchmark the next generation of scientific foundation models and intelligent agents. The toolkit is open-sourced and actively maintained to foster community-driven development and progress in AI4Science.

DarkPatterns-LLM: A Multi-Layer Benchmark for Detecting Manipulative and Harmful AI Behavior

arXiv:2512.22470v1 Announce Type: new Abstract: The proliferation of Large Language Models (LLMs) has intensified concerns about manipulative or deceptive behaviors that can undermine user autonomy, trust, and well-being. Existing safety benchmarks predominantly rely on coarse binary labels and fail to capture the nuanced psychological and social mechanisms constituting manipulation. We introduce \textbf{DarkPatterns-LLM}, a comprehensive benchmark dataset and diagnostic framework for fine-grained assessment of manipulative content in LLM outputs across seven harm categories: Legal/Power, Psychological, Emotional, Physical, Autonomy, Economic, and Societal Harm. Our framework implements a four-layer analytical pipeline comprising Multi-Granular Detection (MGD), Multi-Scale Intent Analysis (MSIAN), Threat Harmonization Protocol (THP), and Deep Contextual Risk Alignment (DCRA). The dataset contains 401 meticulously curated examples with instruction-response pairs and expert annotations. Through evaluation of state-of-the-art models including GPT-4, Claude 3.5, and LLaMA-3-70B, we observe significant performance disparities (65.2\%--89.7\%) and consistent weaknesses in detecting autonomy-undermining patterns. DarkPatterns-LLM establishes the first standardized, multi-dimensional benchmark for manipulation detection in LLMs, offering actionable diagnostics toward more trustworthy AI systems.
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