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Moving beyond monogenic disorders in clinical healthcare

Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02931-2

Our understanding of the genetic mechanisms underlying rare diseases has rapidly advanced over the past decade, largely because of technological innovations. Yet clinical practice still has a strong monogenic focus, leaving many individuals undiagnosed. This Comment outlines how technological advances such as long-read sequencing should be adopted to increase multivariant testing in the clinic.

The ethics of multi-cancer screening

Nature Medicine, Published online: 05 January 2026; doi:10.1038/s41591-025-04111-w

Multi-cancer detection tests offer a new paradigm in cancer screening — the use of a single test to simultaneously screen for many cancers — but they raise important ethical questions for their development, evaluation and possible implementation.
  • ✇MIT Technology Review
  • The overlooked driver of digital transformation MIT Technology Review Insights
    When business leaders talk about digital transformation, their focus often jumps straight to cloud platforms, AI tools, or collaboration software. Yet, one of the most fundamental enablers of how organizations now work, and how employees experience that work, is often overlooked: audio. As Genevieve Juillard, CEO of IDC, notes, the shift to hybrid collaboration made every space, from corporate boardrooms to kitchen tables, meeting-ready almost overnight. In the scramble, audio quality oft
     

The overlooked driver of digital transformation

When business leaders talk about digital transformation, their focus often jumps straight to cloud platforms, AI tools, or collaboration software. Yet, one of the most fundamental enablers of how organizations now work, and how employees experience that work, is often overlooked: audio.

As Genevieve Juillard, CEO of IDC, notes, the shift to hybrid collaboration made every space, from corporate boardrooms to kitchen tables, meeting-ready almost overnight. In the scramble, audio quality often lagged, creating what research now shows is more than a nuisance. Poor sound can alter how speakers are perceived, making them seem less credible or even less trustworthy.

“Audio is the gatekeeper of meaning,” stresses Julliard. “If people can’t hear clearly, they can’t understand you. And if they can’t understand you, they can’t trust you, and they can’t act on what you said. And no amount of sharp video can fix that.” Without clarity, comprehension and confidence collapse.

For Shure, which has spent a century advancing sound technology, the implications extend far beyond convenience. Chris Schyvinck, Shure’s president and CEO, explains that ineffective audio undermines engagement and productivity. Meetings stall, decisions slow, and fatigue builds.

“Use technology to make hybrid meetings seamless, and then be clear on which conversations truly require being in the same physical space,” says Juillard. “If you can strike that balance, you’re not just making work more efficient, you’re making it more sustainable, you’re also making it more inclusive, and you’re making it more resilient.”

When audio is prioritized on equal footing with video and other collaboration tools, organizations can gain something rare: frictionless communication. That clarity ensures the machines listening in, from AI transcription engines to real-time translation systems, can deliver reliable results.

The research from Shure and IDC highlights two blind spots for leaders. First, buying decisions too often privilege price over quality, with costly consequences in productivity and trust. Second, organizations underestimate the stress poor sound imposes on employees, intensifying the cognitive load of already demanding workdays. Addressing both requires leaders to view audio not as a peripheral expense but as core infrastructure.

Looking ahead, audio is becoming inseparable from AI-driven collaboration. Smarter systems can already filter out background noise, enhance voices in real time, and integrate seamlessly into hybrid ecosystems.

“We should be able to provide improved accessibility and a more equitable meeting experience for people,” says Schyvinck.

For Schyvinck and Juillard, the future belongs to companies that treat audio transformation as an integral part of digital transformation, building workplaces that are more sustainable, equitable, and resilient.

This episode of Business Lab is produced in partnership with Shure.

Full Transcript

Megan Tatum: From MIT Technology Review, I’m Megan Tatum, and this is Business Lab, the show that helps business leaders make sense of new technologies coming out of the lab and into the marketplace.

This episode is produced in partnership with Shure.

As companies continue their journeys towards digital transformation, audio modernization is an often overlooked but key component of any successful journey. Clear audio is imperative not only for quality communication, but also for brand equity, both for internal and external stakeholders and even the company as a whole.

Two words for you: audio transformation.

My guests today are Chris Schyvinck, President and CEO at Shure. And Genevieve Juillard, CEO at IDC.

Welcome Chris and Genevieve.


Chris Schyvinck: It’s really nice to be here. Thank you very much.

Genevieve Juillard: Yeah, thank you so much for having us. Great to be here.

Megan Tatum: Thank you both so much for being here. Genevieve, we could start with you. Let’s start with some history perhaps for context. How would you describe the evolution of audio technology and how use cases and our expectations of audio have evolved? What have been some of the major drivers throughout the years and more recently, perhaps would you consider the pandemic to be one of those drivers?

Genevieve: It’s interesting. If you go all the way back to 1976, Norman Macrae of The Economist predicted that video chat would actually kill the office, that people would just work from home. Obviously, that didn’t happen then, but the core technology for remote collaboration has actually been around for decades. But until the pandemic, most of us only experienced it in very specific contexts. Offices had dedicated video conferencing rooms and most ran on expensive proprietary systems. And then almost overnight, everything including literally the kitchen table had to be AV ready. The cultural norms shifted just as fast. Before the pandemic, it was perfectly fine to keep your camera off in a meeting, and now that’s seen as disengaged or even rude, and that changes what normalized video conferencing and my hybrid meetings.

But in a rush to equip a suddenly remote workforce, we hit two big problems. Supply chain disruptions and a massive spike in demand. High-quality gear was hard to get so low-quality audio and video became the default. And here’s a key point. We now know from research that audio quality matters more than video quality for meeting outcomes. You can run a meeting without video, but you can’t run a meeting without clear audio. Audio is the gatekeeper of meaning. If people can’t hear clearly, they can’t understand you. And if they can’t understand you, they can’t trust you and they can’t act on what you said. And no amount of sharp video can fix that.

Megan: Oh, true. It’s fascinating, isn’t it? And Chris, Shure and IDC recently released some research titled “The Hidden Influencer Rethinking Audio Could Impact Your Organization Today, Tomorrow, and Forever.” The research highlighted that importance of audio that Genevieve’s talking about in today’s increasingly virtual world. What did you glean from those results and did anything surprise you?

Chris: Yeah, well, the research certainly confirmed a lot of hunches we’ve had through the years. When you think about a company like Shure that’s been doing audio for 100 years, we just celebrated that anniversary this year.

Megan: Congratulations.

Chris: Our legacy business is over more in the music and performance arena. And so just what Genevieve said in terms of, “Yeah, you can have a performance and look at somebody, but that’s like 10% of it, right? 90% is hearing that person sing, perform, and talk.” We’ve always, of course, from our perspective, understood that clean, clear, crisp audio is what is needed in any setting. When you translate what’s happening on the stage into a meeting or collaboration space at a corporation, we’ve thought that that is just equally as important.

And we always had this hunch that if people don’t have the good audio, they’re going to have fatigue, they’re going to get a little disengaged, and the whole meeting is going to become quite unproductive. The research just really amplified that hunch for us because it really depicted the fact that people not only get kind of frustrated and disengaged, they might actually start to distrust what the other person with bad audio is saying or just cast it in a different light. And the degree to which that frustration becomes almost personal was very surprising to us. Like I said, it validated some hunches, but it really put an exclamation point on it for us.

Megan: And Genevieve, based on the research results, I understand that IDC pulled together some recommendations for organizations. What is it that leaders need to know and what is the biggest blind spot for them to overcome as well?

Genevieve: The biggest blind spot is this. If your microphone has poor audio quality, like Chris said, people will literally perceive you as less intelligent and less trustworthy. And by the way, that’s not an opinion. It’s what the science says. But yet, when we surveyed first time business buyers, the number one factor they used to choose audio gear was price. However, for repeat buyers, the top factor flipped to audio quality. My guess is they learn the lesson the hard way. The second blind spot is to Chris’s point, it’s the stress that bad audio creates. Poor sound forces your brain to work harder to decode what’s being said. That’s a cognitive load and it creates stress. And over a full day of meetings, that stress adds up. Now, we don’t have long-term studies yet on the effects, but we do know that prolonged stress is something that every company should be working to reduce.

Good audio lightens that cognitive load. It keeps people engaged and it levels the playing field. Whether you’re in a room or you’re halfway across the world, and here’s one that’s often overlooked, bad audio can sabotage AI transcription tools. As AI becomes more and more central to everyday work, that starts to become really critical. If your audio isn’t clear, the transcription won’t be accurate. And there’s a world of difference between working, for example, the consulting department and the insulting department, and that is an actual example from the field.

The bottom line is you fix the audio, you cut friction, you save time, and you make meetings more productive.

Megan: I mean, it’s just a huge game changer, isn’t it, really? I mean, and given that, Chris, in your experience across industries, are audio technologies being included in digital transformation strategies and also artificial intelligence implementation? Do we need a separate audio transformation perhaps?

Chris: Well, like I mentioned earlier, yes, people tend to initially focus on that visual platform, but increasingly the attention to audio is really coming into focus. And I’d hate to tear apart audio as a separate sort of strategy because at the same time, we, as an audio expert, are trying to really seamlessly integrate audio into the rest of the ecosystem. It really does need to be put on an equal footing with the rest of the components in that ecosystem. And to Genevieve’s point, as we are seeing audio and video systems with more AI functionalities, the importance of real-time translations that are being used, voice recognition, being able to attribute who said what in a meeting and take action items, it’s really, I think starting to elevate the importance of that clear audio. And it’s got to be part of a comprehensive, really collaboration plan that helps some company figure out what’s their whole digital transformation about. It just really has to be included in that comprehensive plan, but put on equal footing with the rest of the components in that system.

Megan: Yeah, absolutely. And in the broader landscape, Genevieve, in terms of discussing the importance of audio quality, what have you noticed across research projects about the effects of good and bad audio, not only from that company perspective, but from employee and client perspectives as well?

Genevieve: Well, let’s start with employees.

Megan: Sure.

Genevieve: Bad audio adds friction you don’t need, we’ve talked about this. When you’re straining to hear or make sense of what’s being said, your brain is burning energy on decoding instead of contributing. That frustration, it builds up, and by the end of the day, it hurts productivity. From a company perspective, the stakes get even higher. Meetings are where decisions happen or at least where they’re supposed to happen. And if people can’t hear clearly, decisions get delayed, mistakes creep in, and the whole process slows down. Poor audio doesn’t just waste time, it chips away at the ability to move quickly and confidently. And then there’s the client experience. So whether it’s in sales, customer service, or any external conversation, poor audio can make you sound less credible and yet less trustworthy. Again, that’s not my opinion. That’s what the research shows. So that’s quite a big risk when you’re trying to close a deal or solve a major problem.

The takeaway is good audio, it matters, it’s a multiplier. It makes meetings more productive and it can help decisions happen faster and client interactions be stronger.

Megan: It’s just so impactful, isn’t it, in so many different ways. I mean, Chris, how are you seeing these research results reflected as companies work through digital and AI transformations? What is it that leaders need to understand about what is involved in audio implementation across their organization?

Chris: Well, like I said earlier, I do think that audio is finally maybe getting its place in the spotlight a little bit up there with our cousins over in the video side. Audio, it’s not just a peripheral aspect anymore. It’s a very integral part of that sort of comprehensive collaboration plan I was talking about earlier. And when we think about how can we contribute solutions that are really more easy to use for our end users, because if you create something complicated, we were talking about the days gone by of walking into a room. It’s a very complicated system, and you need to find the right person that knows how to run it. Increasingly, you just need to have some plug and play kind of solutions. We’re thinking about a more sustainable strategy for our solutions where we make really high-quality hardware. We’ve done that account for a hundred years. People will come up to me and tell the story of the SM58 microphone they bought in 1980 and how they’re still using it every day.

We know how to do that part of it. If somebody is willing to make that investment upfront, put some high-quality hardware into their system, then we are getting to the point now where updates can be handled via software downloads or cloud connectivity. And just really being able to provide sort of a sustainable solution for people over time.

More in our industry, we’re collaborating with other industry partners to go in that direction, make something that’s very simple for anybody to walk into a room or on their individual at home setup and do something pretty simple. And I think we have the right industry groups, the right industry associations that can help make sure that the ecosystems have the proper standards, the right kind of ways to make sure everything is interoperable within a system. We’re all kind of heading in that direction with that end user in mind.

Megan: Fantastic. And when the internet of things was emerging, efforts began to create sort of these data ecosystems, it seems there’s an argument to be made that we need audio ecosystems as well. I wonder, Chris, what might an audio ecosystem look like and what would be involved in implementation?

Chris: Well, I think it does have to be part of that bigger ecosystem I was just talking about where we do collaborate with others in industry and we try to make sure that we’re all playing by the kind of same set of rules and protocols and standards and whatnot. And when you think about compatibility across all the devices that sit in a room or sit in your, again, maybe your at home setup, making sure that the audio quality is as good as it can be, that you can interoperate with everything else in the system. That’s just become very paramount in our day-to-day work here. Your hardware has to be scalable like I just alluded to a moment ago. You have to figure out how you can integrate with existing technologies, different platforms.

We were joking when we came into this session that when you’re going from the platform at your company, maybe you’re on Teams and you go into a Zoom setting or you go into a Google setting, you really have to figure out how to adapt to all those different sort of platforms that are out there. I think the ecosystem that we’re trying to build, we’re trying to be on that equal footing with the rest of the components in that system. And people really do understand that if you want to have extra functionalities in meetings and you want to be able to transcribe or take notes and all of that, that audio is an absolutely critical piece.

Megan: Absolutely. And speaking of bit of all those different platforms and use cases, that sort of audio is so relevant to Genevieve that goes back to this idea of in audio one size does not fit all and needs may change. How can companies also plan their audio implementations to be flexible enough to meet current needs and to be able to grow with future advancements?

Genevieve: I’m glad you asked this question. Even years after the pandemic, many companies, they’re still trying to get the balance right between remote, in office, how to support it. But even if a company has a strict return to office in-person policy, the reality is that work still isn’t going away for that company. They may have teams across cities or countries, clients and external stakeholders will have their own office preferences that they have to adapt to. Supporting hybrid work is actually becoming more important, not less. And our research shows that companies are leaning into, not away from, hybrid setups. About one third of companies are now redesigning or resizing office spaces every single year. For large organizations with multiple sites, staggered leases, that’s a moving target. It’s really important that they have audio solutions that can work before, during, after all of those changes that they’re constantly making. And so that’s where flexibility becomes really important. Companies need to buy not just for right now, but for the future.

And so here’s IDC’s kind of pro-tip, which is make sure as a company that you go with a provider that offers top-notch audio quality and also has strong partnerships and certifications with the big players and communications technology because that will save you money in the long run. Your systems will stay compatible, your investments will last longer, and you won’t be scrambling when that next shift happens.

Megan: Of course. And speaking of building for the future, as companies begin to include sustainability in their company goals, Chris, I wonder how can audio play a role in those sustainability efforts and how might that play into perhaps the return on investment in building out a high-quality audio ecosystem?

Chris: Well, I totally agree with what Genevieve just said in terms of hybrid work is not going anywhere. You get all of those big headlines that talk about XYZ company telling people to get back into the office. And I saw a fantastic piece of data just last week that showed the percent of in-office hours of the American workers versus out-of-office remote kind of work. It has basically been flatlined since 2022. This is our new way of working. And of course, like Genevieve mentioned, you have people in all these different locations. And in a strange way, living through the pandemic did teach us that we can do some things by not having to hop on an airplane and travel to go somewhere. Certainly that helps with a more sustainable strategy over time, and you’re saving on travel and able to get things done much more quickly.

And then from a product offering perspective, I’ll go back to the vision I was painting earlier where we and others in our industry see that we can create great solid hardware platforms. We’ve done it for decades, and now that advancements around AI and all of our software that enables products and everything else that has happened in the last probably decade, we can get enhancements and additions and new functionality to people in simpler ways on existing hardware. I think we’re all careening down this path of having a much more sustainable ecosystem for all collaboration. It’s really quite an exciting time, and that pays off with any company implementing a system, their ROI is going to be much better in the long run.

Megan: Absolutely. And Genevieve, what trends around sustainability are you seeing? What opportunities do you see for audio to play into those sustainability efforts going forward?

Genevieve: Yeah, similar to Chris. In some industries, there’s still a belief that the best work happens when everyone’s in the same room. And yes, face-to-face time is really important for building relationships, for brainstorming, for closing big deals, but it does come at a cost. The carbon footprint of daily commutes, the sales visits, the constant business travel. And then there’s the basic consideration, as we’ve talked about, of just pure practicality. The good news is with the right AV setup, especially high-quality audio, many of those interactions can happen virtually without losing effectiveness, as Chris said it, but our research shows it.

Our research shows that virtual meetings can be just as productive as in-person ones, and every commute or flight you avoid, of course makes a measurable sustainability impact. I don’t think, personally, that the takeaway is replace all in-person meetings, but instead it’s to be intentional. Use technology to make hybrid meetings seamless, and then be clear on which conversations truly require being in the same physical space. If you can strike that balance, you’re not just making work more efficient, you’re making it more sustainable, you’re also making it more inclusive, and you’re making it more resilient.

Megan: Such an important point. And let’s close with a future forward look, if we can. Genevieve, what innovations or advancements in the audio field are you most excited to see to come to fruition, and what potential interesting use cases do you see on the horizon?

Genevieve: I’m especially interested in how AI and audio are converging. We’re now seeing AI that can identify and isolate human voices in noisy environments. For example, right now, there are some jets flying overhead. It’s very loud in here, but I suspect you may not even know that that’s happening.

Megan: We can’t hear a thing. No.

Genevieve: Right. That technology, it’s pulling voices forward so that conversations like ours are crystal clear. And that’s a big deal, especially as companies invest more and more in AI tools, especially for that translating, transcribing and summarizing meetings. But as we’ve talked before, AI is only as good as the audio it hears. If the sound is poor or a word gets misheard, the meaning can shift entirely. And sometimes that’s just inconvenient, or it can even be funny. But in really high stakes settings, like healthcare for example, a single mis-transcribed word can have serious consequences. So that’s why our position as high quality audio is critical and it’s necessary for making AI powered communication accurate, trustworthy, and useful because when the input is clean, the output can actually live up to its promise.

Megan: Fantastic. And Chris, finally, what are you most excited to see developed? What advancements are you most looking forward to seeing?

Chris: Well, I really do believe that this is one of the most exciting times that I know I’ve lived through in my career. Just the pace of how fast technology is moving, the sudden emergence of all things AI. I was actually in a roundtable session of CEOs yesterday from lots of different industries, and the facilitator was talking about change management internally in companies as you’re going through all of these technology shifts and some of the fear that people have around AI and things like that. And the facilitator asked each of us to give one word that describes how we’re feeling right now. And the first CEO that went used the word dread. And that absolutely floored me because you enter into these eras with some skepticism and trying to figure out how to make things work and go down the right path. But my word was truly optimism.

When I look at all the ways that we are able to deliver better audio to people more quickly, there’s so many opportunities in front of us. We’re working on things outside of AI like algorithms that Genevieve just mentioned that filter out the bad sounds that you don’t want entering into a meeting. We’ve been doing that for quite a long time now. There’s also opportunities to do real time audio improvements, enhancements, make audio more personal for people. How do they want to be able to very simply, through voice commands perhaps, adjust their audio? There shouldn’t have to be a whole lot of techie settings that come along with our solutions.

We should be able to provide improved accessibility and a little bit more equitable meeting experience for people. And we’re looking at tech technology solutions around immersive audio. How can you maybe feel like you’re a bit more engaged in the meeting, kind of creating some realistic virtual experiences, if you will. There’s just so many opportunities in front of us, and I can just picture a day when you walk into a room and you tell the room, “Hey, call Genevieve. We’re going to have a meeting for an hour, and we might need to have Megan on call to come in at a certain time.”

And all of this will just be very automatic, very seamless, and we’ll be able to see each other and talk at the same time. And this isn’t years away. This is happening really, really quickly. And I do think it’s a really exciting time for audio and just all together collaboration in our industry.

Megan: Absolutely. Sounds like there’s plenty of reason to be optimistic. Thank you both so much.

That was Chris Schyvinck, President and CEO at Shure. And Genevieve Juillard, CEO at IDC, whom I spoke with from Brighton, England.

That’s it for this episode of Business Lab. I’m your host, Megan Tatum. I’m a contributing editor at Insights, the custom publishing division of MIT Technology Review. We were founded in 1899 at the Massachusetts Institute of Technology, and you can find us in print on the web and at events each year around the world. For more information about us and the show, please check out our website at technologyreview.com.


This show is available wherever you get your podcasts. And if you enjoy this episode, we hope you’ll take a moment to rate and review us. Business Lab is a production of MIT Technology Review, and this episode was produced by Giro Studios. Thanks for listening.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff. It was researched, designed, and written entirely by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

Digital Twin based Automatic Reconfiguration of Robotic Systems in Smart Environments

arXiv:2511.00094v2 Announce Type: replace-cross Abstract: Robotic systems have become integral to smart environments, enabling applications ranging from urban surveillance and automated agriculture to industrial automation. However, their effective operation in dynamic settings - such as smart cities and precision farming - is challenged by continuously evolving topographies and environmental conditions. Traditional control systems often struggle to adapt quickly, leading to inefficiencies or operational failures. To address this limitation, we propose a novel framework for autonomous and dynamic reconfiguration of robotic controllers using Digital Twin technology. Our approach leverages a virtual replica of the robot's operational environment to simulate and optimize movement trajectories in response to real-world changes. By recalculating paths and control parameters in the Digital Twin and deploying the updated code to the physical robot, our method ensures rapid and reliable adaptation without manual intervention. This work advances the integration of Digital Twins in robotics, offering a scalable solution for enhancing autonomy in smart, dynamic environments.

Artificial intelligence in hepatopathy diagnosis and treatment: Big data analytics, deep learning, and clinical prediction models

World J Gastroenterol. 2025 Dec 14;31(46):111176. doi: 10.3748/wjg.v31.i46.111176.

ABSTRACT

Artificial intelligence (AI) is rapidly transforming the landscape of hepatology by enabling automated data interpretation, early disease detection, and individualized treatment strategies. Chronic liver diseases, including non-alcoholic fatty liver disease, cirrhosis, and hepatocellular carcinoma, often progress silently and pose diagnostic challenges due to reliance on invasive biopsies and operator-dependent imaging. This review explores the integration of AI across key domains such as big data analytics, deep learning-based image analysis, histopathological interpretation, biomarker discovery, and clinical prediction modeling. AI algorithms have demonstrated high accuracy in liver fibrosis staging, hepatocellular carcinoma detection, and non-alcoholic fatty liver disease risk stratification, while also enhancing survival prediction and treatment response assessment. For instance, convolutional neural networks trained on portal venous-phase computed tomography have achieved area under the curves up to 0.92 for significant fibrosis (F2-F4) and 0.89 for advanced fibrosis, with magnetic resonance imaging-based models reporting comparable performance. Advanced methodologies such as federated learning preserve patient privacy during cross-center model training, and explainable AI techniques promote transparency and clinician trust. Despite these advancements, clinical adoption remains limited by challenges including data heterogeneity, algorithmic bias, regulatory uncertainty, and lack of real-time integration into electronic health records. Looking forward, the convergence of multi-omics, imaging, and clinical data through interpretable and validated AI frameworks holds great promise for precision liver care. Continued efforts in model standardization, ethical oversight, and clinician-centered deployment will be essential to realize the full potential of AI in hepatopathy diagnosis and treatment.

PMID:41479639 | PMC:PMC12754151 | DOI:10.3748/wjg.v31.i46.111176

A clinically validated 3D deep learning approach for quantifying vascular invasion in pancreatic cancer

npj Digital Medicine, Published online: 31 December 2025; doi:10.1038/s41746-025-02260-3

A clinically validated 3D deep learning approach for quantifying vascular invasion in pancreatic cancer

Autologous multiantigen-targeted T cell therapy for pancreatic cancer: a phase 1/2 trial

Nature Medicine, Published online: 02 January 2026; doi:10.1038/s41591-025-04043-5

Results of the phase 1/2 TACTOPS trial show that autologous T cell therapy targeting PRAME, SSX2, MAGEA4, Survivin and NY-ESO-1 in patients with pancreatic ductal adenocarcinoma is feasible and safe, and leads to encouraging clinical responses and evidence of antigen spreading in responders.

Quantifying the global eco-footprint of wearable healthcare electronics

Nature, Published online: 31 December 2025; doi:10.1038/s41586-025-09819-w

An integrated systems engineering framework based on life-cycle inventories is used to quantify the global eco-footprint of wearable healthcare electronics and identify effective mitigation strategies.

Artificial Intelligence Applications in the Diagnosis, Treatment, and Prognosis of Hepatocellular Carcinoma

Gut Liver. 2025 Dec 31. doi: 10.5009/gnl250268. Online ahead of print.

ABSTRACT

The global burden of hepatocellular carcinoma (HCC) has shifted from viral to nonviral etiologies. However, successful antiviral therapy does not fully eliminate the risk of HCC, underscoring the demand for more effective surveillance strategies. Current screening methods, such as semiannual ultrasonography and the measurement of α-fetoprotein levels, offer suboptimal sensitivity for early detection. A cost-effective, reliable surveillance approach remains an unmet need. The Barcelona Clinic Liver Cancer staging system provides a framework to guide HCC therapy; yet, some gray zone exists, particularly for patients with intermediate-stage disease. Although tyrosine kinase inhibitors and immunotherapies have transformed the therapeutic landscape, their efficacies vary among patients, highlighting the necessity for personalized treatment strategies. In response to these challenges, artificial intelligence (AI) approaches have emerged as transformative tools in healthcare. By processing complex, nonlinear relationships and uncovering hidden patterns in clinical data, AI methods offer capabilities beyond those of traditional statistical methods. Furthermore, AI-driven multi-omics analysis holds promise for identifying novel biomarkers, thereby advancing precision medicine for HCC patients. This review introduces the potential of AI applications in enhancing the diagnosis, treatment, and prognosis of HCC.

PMID:41472345 | DOI:10.5009/gnl250268

Artificial Intelligence Applications in the Diagnosis, Treatment, and Prognosis of Hepatocellular Carcinoma

Gut Liver. 2025 Dec 31. doi: 10.5009/gnl250268. Online ahead of print.

ABSTRACT

The global burden of hepatocellular carcinoma (HCC) has shifted from viral to nonviral etiologies. However, successful antiviral therapy does not fully eliminate the risk of HCC, underscoring the demand for more effective surveillance strategies. Current screening methods, such as semiannual ultrasonography and the measurement of α-fetoprotein levels, offer suboptimal sensitivity for early detection. A cost-effective, reliable surveillance approach remains an unmet need. The Barcelona Clinic Liver Cancer staging system provides a framework to guide HCC therapy; yet, some gray zone exists, particularly for patients with intermediate-stage disease. Although tyrosine kinase inhibitors and immunotherapies have transformed the therapeutic landscape, their efficacies vary among patients, highlighting the necessity for personalized treatment strategies. In response to these challenges, artificial intelligence (AI) approaches have emerged as transformative tools in healthcare. By processing complex, nonlinear relationships and uncovering hidden patterns in clinical data, AI methods offer capabilities beyond those of traditional statistical methods. Furthermore, AI-driven multi-omics analysis holds promise for identifying novel biomarkers, thereby advancing precision medicine for HCC patients. This review introduces the potential of AI applications in enhancing the diagnosis, treatment, and prognosis of HCC.

PMID:41472345 | DOI:10.5009/gnl250268

Machine Learning-Based Multi-Omics Integration for Identification of Hepatocellular Carcinoma Biomarkers in an Egyptian Cohort

J Proteome Res. 2025 Dec 30. doi: 10.1021/acs.jproteome.5c00741. Online ahead of print.

ABSTRACT

Hepatocellular carcinoma (HCC) ranks among the most common causes of cancer-related deaths globally. The high incidence of HCC is largely linked to chronic hepatitis virus infections, liver cirrhosis, and exposure to carcinogenic substances. Egypt has one of the world's highest burdens of HCC, with liver cirrhosis from chronic hepatitis C virus (HCV) infection as the primary risk factor. Malignant conversion of cirrhosis to HCC is often fatal in part because adequate biomarkers are not available for diagnosis of HCC in the early stage. Therefore, there is a critical need for more effective biomarkers to detect HCC at an early stage, when therapeutic intervention is more likely to be successful. Multiomics integration has emerged as a powerful strategy to uncover biomarkers and better understand the molecular underpinnings of complex diseases such as HCC. This study summarizes findings from multiple untargeted and targeted mass spectrometry-based analyses of proteins, N-linked glycans, and metabolites performed on blood samples from HCC cases and cirrhotic cohorts recruited in Egypt. Integrative analysis using machine learning methods is performed to identify a panel of multiomics features that differentiates HCC cases from the high-risk population of cirrhotic patients with liver cirrhosis.

PMID:41467861 | DOI:10.1021/acs.jproteome.5c00741

  • ✇MIT Technology Review
  • The ascent of the AI therapist Becky Ferreira
    We’re in the midst of a global mental-­health crisis. More than a billion people worldwide suffer from a mental-health condition, according to the World Health Organization. The prevalence of anxiety and depression is growing in many demographics, particularly young people, and suicide is claiming hundreds of thousands of lives globally each year. Given the clear demand for accessible and affordable mental-health services, it’s no wonder that people have looked to artificial intelligence for
     

The ascent of the AI therapist

30 December 2025 at 19:00

We’re in the midst of a global mental-­health crisis. More than a billion people worldwide suffer from a mental-health condition, according to the World Health Organization. The prevalence of anxiety and depression is growing in many demographics, particularly young people, and suicide is claiming hundreds of thousands of lives globally each year.

Given the clear demand for accessible and affordable mental-health services, it’s no wonder that people have looked to artificial intelligence for possible relief. Millions are already actively seeking therapy from popular chatbots like OpenAI’s ChatGPT and Anthropic’s Claude, or from specialized psychology apps like Wysa and Woebot. On a broader scale, researchers are exploring AI’s potential to monitor and collect behavioral and biometric observations using wearables and smart devices, analyze vast volumes of clinical data for new insights, and assist human mental-health professionals to help prevent burnout. 

But so far this largely uncontrolled experiment has produced mixed results. Many people have found solace in chatbots based on large language models (LLMs), and some experts see promise in them as therapists, but other users have been sent into delusional spirals by AI’s hallucinatory whims and breathless sycophancy. Most tragically, multiple families have alleged that chatbots contributed to the suicides of their loved ones, sparking lawsuits against companies responsible for these tools. In October, OpenAI CEO Sam Altman revealed in a blog post that 0.15% of ChatGPT users “have conversations that include explicit indicators of potential suicidal planning or intent.” That’s roughly a million people sharing suicidal ideations with just one of these software systems every week.

The real-world consequences of AI therapy came to a head in unexpected ways in 2025 as we waded through a critical mass of stories about human-chatbot relationships, the flimsiness of guardrails on many LLMs, and the risks of sharing profoundly personal information with products made by corporations that have economic incentives to harvest and monetize such sensitive data. 

Several authors anticipated this inflection point. Their timely books are a reminder that while the present feels like a blur of breakthroughs, scandals, and confusion, this disorienting time is rooted in deeper histories of care, technology, and trust. 

LLMs have often been described as “black boxes” because nobody knows exactly how they produce their results. The inner workings that guide their outputs are opaque because their algorithms are so complex and their training data is so vast. In mental-health circles, people often describe the human brain as a “black box,” for analogous reasons. Psychology, psychiatry, and related fields must grapple with the impossibility of seeing clearly inside someone else’s head, let alone pinpointing the exact causes of their distress. 

These two types of black boxes are now interacting with each other, creating unpredictable feedback loops that may further impede clarity about the origins of people’s mental-­health struggles and the solutions that may be possible. Anxiety about these developments has much to do with the explosive recent advances in AI, but it also revives decades-old warnings from pioneers such as the MIT computer scientist Joseph Weizenbaum, who argued against computerized therapy as early as the 1960s.  


cover of Dr Bot
Dr. Bot: Why Doctors Can Fail Us— and
How AI Could Save Lives

Charlotte Blease
YALE UNIVERSITY PRESS, 2025

Charlotte Blease, a philosopher of medicine, makes the optimist’s case in Dr. Bot: Why Doctors Can Fail Us—and How AI Could Save Lives. Her book broadly explores the possible positive impacts of AI in a range of medical fields. While she remains clear-eyed about the risks, warning that readers who are expecting “a gushing love letter to technology” will be disappointed, she suggests that these models can help relieve patient suffering and medical burnout alike.

“Health systems are crumbling under patient pressure,” Blease writes. “Greater burdens on fewer doctors create the perfect petri dish for errors,” and “with palpable shortages of doctors and increasing waiting times for patients, many of us are profoundly frustrated.”

Blease believes that AI can not only ease medical professionals’ massive workloads but also relieve the tensions that have always existed between some patients and their caregivers. For example, people often don’t seek needed care because they are intimidated or fear judgment from medical professionals; this is especially true if they have mental-health challenges. AI could allow more people to share their concerns, she argues. 

But she’s aware that these putative upsides need to be weighed against major drawbacks. For instance, AI therapists can provide inconsistent and even dangerous responses to human users, according to a 2025 study, and they also raise privacy concerns, given that AI companies are currently not bound by the same confidentiality and HIPAA standards as licensed therapists. 

While Blease is an expert in this field, her motivation for writing the book is also personal: She has two siblings with an incurable form of muscular dystrophy, one of whom waited decades for a diagnosis. During the writing of her book, she also lost her partner to cancer and her father to dementia within a devastating six-month period. “I witnessed first-hand the sheer brilliance of doctors and the kindness of health professionals,” she writes. “But I also observed how things can go wrong with care.”


cover of the Silicon Shrink
The Silicon Shrink: How Artificial Intelligence Made the World an Asylum
Daniel Oberhaus
MIT PRESS, 2025

A similar tension animates Daniel Oberhaus’s engrossing book The Silicon Shrink: How Artificial Intelligence Made the World an Asylum. Oberhaus starts from a point of tragedy: the loss of his younger sister to suicide. As Oberhaus carried out the “distinctly twenty-first-century mourning process” of sifting through her digital remains, he wondered if technology could have eased the burden of the psychiatric problems that had plagued her since childhood.

“It seemed possible that all of this personal data might have held important clues that her mental health providers could have used to provide more effective treatment,” he writes. “What if algorithms running on my sister’s smartphone or laptop had used that data to understand when she was in distress? Could it have led to a timely intervention that saved her life? Would she have wanted that even if it did?”

This concept of digital phenotyping—in which a person’s digital behavior could be mined for clues about distress or illness—seems elegant in theory. But it may also become problematic if integrated into the field of psychiatric artificial intelligence (PAI), which extends well beyond chatbot therapy.

Oberhaus emphasizes that digital clues could actually exacerbate the existing challenges of modern psychiatry, a discipline that remains fundamentally uncertain about the underlying causes of mental illnesses and disorders. The advent of PAI, he says, is “the logical equivalent of grafting physics onto astrology.” In other words, the data generated by digital phenotyping is as precise as physical measurements of planetary positions, but it is then integrated into a broader framework—in this case, psychiatry—that, like astrology, is based on unreliable assumptions.  

Oberhaus, who uses the phrase “swipe psychiatry” to describe the outsourcing of clinical decisions based on behavioral data to LLMs, thinks that this approach cannot escape the fundamental issues facing psychiatry. In fact, it could worsen the problem by causing the skills and judgment of human therapists to atrophy as they grow more dependent on AI systems. 

He also uses the asylums of the past—in which institutionalized patients lost their right to freedom, privacy, dignity, and agency over their lives—as a touchstone for a more insidious digital captivity that may spring from PAI. LLM users are already sacrificing privacy by telling chatbots sensitive personal information that companies then mine and monetize, contributing to a new surveillance economy. Freedom and dignity are at stake when complex inner lives are transformed into data streams tailored for AI analysis. 

AI therapists could flatten humanity into patterns of prediction, and so sacrifice the intimate, individualized care that is expected of traditional human therapists. “The logic of PAI leads to a future where we may all find ourselves patients in an algorithmic asylum administered by digital wardens,” Oberhaus writes. “In the algorithmic asylum there is no need for bars on the window or white padded rooms because there is no possibility of escape. The asylum is already everywhere—in your homes and offices, schools and hospitals, courtrooms and barracks. Wherever there’s an internet connection, the asylum is waiting.”


cover of Chatbot Therapy
Chatbot Therapy:
A Critical Analysis of
AI Mental Health Treatment

Eoin Fullam
ROUTLEDGE, 2025

Eoin Fullam, a researcher who studies the intersection of technology and mental health, echoes some of the same concerns in Chatbot Therapy: A Critical Analysis of AI Mental Health Treatment. A heady academic primer, the book analyzes the assumptions underlying the automated treatments offered by AI chatbots and the way capitalist incentives could corrupt these kinds of tools.  

Fullam observes that the capitalist mentality behind new technologies “often leads to questionable, illegitimate, and illegal business practices in which the customers’ interests are secondary to strategies of market dominance.”

That doesn’t mean that therapy-bot makers “will inevitably conduct nefarious activities contrary to the users’ interests in the pursuit of market dominance,” Fullam writes. 

But he notes that the success of AI therapy depends on the inseparable impulses to make money and to heal people. In this logic, exploitation and therapy feed each other: Every digital therapy session generates data, and that data fuels the system that profits as unpaid users seek care. The more effective the therapy seems, the more the cycle entrenches itself, making it harder to distinguish between care and commodification. “The more the users benefit from the app in terms of its therapeutic or any other mental health intervention,” he writes, “the more they undergo exploitation.” 


This sense of an economic and psychological ouroboros—the snake that eats its own tail—serves as a central metaphor in Sike, the debut novel from Fred Lunzer, an author with a research background in AI. 

Described as a “story of boy meets girl meets AI psychotherapist,” Sike follows Adrian, a young Londoner who makes a living ghostwriting rap lyrics, in his romance with Maquie, a business professional with a knack for spotting lucrative technologies in the beta phase. 

cover of Sike
Sike
Fred Lunzer
CELADON BOOKS, 2025

The title refers to a splashy commercial AI therapist called Sike, uploaded into smart glasses, that Adrian uses to interrogate his myriad anxieties. “When I signed up to Sike, we set up my dashboard, a wide black panel like an airplane’s cockpit that showed my daily ‘vitals,’” Adrian narrates. “Sike can analyze the way you walk, the way you make eye contact, the stuff you talk about, the stuff you wear, how often you piss, shit, laugh, cry, kiss, lie, whine, and cough.”

In other words, Sike is the ultimate digital phenotyper, constantly and exhaustively analyzing everything in a user’s daily experiences. In a twist, Lunzer chooses to make Sike a luxury product, available only to subscribers who can foot the price tag of £2,000 per month. 

Flush with cash from his contributions to a hit song, Adrian comes to rely on Sike as a trusted mediator between his inner and outer worlds. The novel explores the impacts of the app on the wellness of the well-off, following rich people who voluntarily commit themselves to a boutique version of the digital asylum described by Oberhaus.

The only real sense of danger in Sike involves a Japanese torture egg (don’t ask). The novel strangely sidesteps the broader dystopian ripples of its subject matter in favor of drunken conversations at fancy restaurants and elite dinner parties. 

The sudden ascent of the AI therapist seems startlingly futuristic, as if it should be unfolding in some later time when the streets scrub themselves and we travel the world through pneumatic tubes.

Sike’s creator is simply “a great guy” in Adrian’s estimation, despite his techno-messianic vision of training the app to soothe the ills of entire nations. It always seems as if a shoe is meant to drop, but in the end, it never does, leaving the reader with a sense of non-resolution.

While Sike is set in the present day, something about the sudden ascent of the AI therapist—­in real life as well as in fiction—seems startlingly futuristic, as if it should be unfolding in some later time when the streets scrub themselves and we travel the world through pneumatic tubes. But this convergence of mental health and artificial intelligence has been in the making for more than half a century. The beloved astronomer Carl Sagan, for example, once imagined a “network of computer psychotherapeutic terminals, something like arrays of large telephone booths” that could address the growing demand for mental-health services.

Oberhaus notes that one of the first incarnations of a trainable neural network, known as the Perceptron, was devised not by a mathematician but by a psychologist named Frank Rosenblatt, at the Cornell Aeronautical Laboratory in 1958. The potential utility of AI in mental health was widely recognized by the 1960s, inspiring early computerized psychotherapists such as the DOCTOR script that ran on the ELIZA chatbot developed by Joseph Weizenbaum, who shows up in all three of the nonfiction books in this article.

Weizenbaum, who died in 2008, was profoundly concerned about the possibility of computerized therapy. “Computers can make psychiatric judgments,” he wrote in his 1976 book Computer Power and Human Reason. “They can flip coins in much more sophisticated ways than can the most patient human being. The point is that they ought not to be given such tasks. They may even be able to arrive at ‘correct’ decisions in some cases—but always and necessarily on bases no human being should be willing to accept.”

It’s a caution worth keeping in mind. As AI therapists arrive at scale, we’re seeing them play out a familiar dynamic: Tools designed with superficially good intentions are enmeshed with systems that can exploit, surveil, and reshape human behavior. In a frenzied attempt to unlock new opportunities for patients in dire need of mental-health support, we may be locking other doors behind them.

Becky Ferreira is a science reporter based in upstate New York and author of First Contact: The Story of Our Obsession with Aliens.

PIC-SURE: an open-source platform for integrating clinical and genomic data

npj Digital Medicine, Published online: 30 December 2025; doi:10.1038/s41746-025-02284-9

PIC-SURE: an open-source platform for integrating clinical and genomic data

Bidirectional RAG: Safe Self-Improving Retrieval-Augmented Generation Through Multi-Stage Validation

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SciEvalKit: An Open-source Evaluation Toolkit for Scientific General Intelligence

arXiv:2512.22334v1 Announce Type: new Abstract: We introduce SciEvalKit, a unified benchmarking toolkit designed to evaluate AI models for science across a broad range of scientific disciplines and task capabilities. Unlike general-purpose evaluation platforms, SciEvalKit focuses on the core competencies of scientific intelligence, including Scientific Multimodal Perception, Scientific Multimodal Reasoning, Scientific Multimodal Understanding, Scientific Symbolic Reasoning, Scientific Code Generation, Science Hypothesis Generation and Scientific Knowledge Understanding. It supports six major scientific domains, spanning from physics and chemistry to astronomy and materials science. SciEvalKit builds a foundation of expert-grade scientific benchmarks, curated from real-world, domain-specific datasets, ensuring that tasks reflect authentic scientific challenges. The toolkit features a flexible, extensible evaluation pipeline that enables batch evaluation across models and datasets, supports custom model and dataset integration, and provides transparent, reproducible, and comparable results. By bridging capability-based evaluation and disciplinary diversity, SciEvalKit offers a standardized yet customizable infrastructure to benchmark the next generation of scientific foundation models and intelligent agents. The toolkit is open-sourced and actively maintained to foster community-driven development and progress in AI4Science.
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