Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
Deployability-Centric Infrastructure-as-Code Generation: Fail, Learn, Refine, and Succeed through LLM-Empowered DevOps Simulation
arXiv:2506.05623v2 Announce Type: replace-cross Abstract: Infrastructure-as-Code (IaC) generation holds significant promise for automating cloud infrastructure provisioning. Recent advances in Large Language Models (LLMs) present a promising opportunity to democratize IaC development by generating deployable infrastructure templates from natural language descriptions. However, current evaluation focuses on syntactic correctness while ignoring deployability, the critical measure of the utility o
-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
-
Causal relationship of immune cell characteristics in hepatocellular carcinoma: A multi-omics analysis based on Mendelian randomization
Medicine (Baltimore). 2025 Dec 5;104(49):e45942. doi: 10.1097/MD.0000000000045942.ABSTRACTThe tumor immune microenvironment of hepatocellular carcinoma (HCC) is complex, yet the causal relationship between immune cell subpopulations and HCC risk remains incompletely elucidated. This study aims to systematically evaluate the causal association between immune cell subpopulations and HCC using Mendelian randomization (MR) analysis, and to validate the biological mechanisms underlying these associat
Causal relationship of immune cell characteristics in hepatocellular carcinoma: A multi-omics analysis based on Mendelian randomization
Medicine (Baltimore). 2025 Dec 5;104(49):e45942. doi: 10.1097/MD.0000000000045942.
ABSTRACT
The tumor immune microenvironment of hepatocellular carcinoma (HCC) is complex, yet the causal relationship between immune cell subpopulations and HCC risk remains incompletely elucidated. This study aims to systematically evaluate the causal association between immune cell subpopulations and HCC using Mendelian randomization (MR) analysis, and to validate the biological mechanisms underlying these associations through multi-omics data. Bidirectional two-sample MR analysis was performed to examine causal relationships between 731 immune cell subpopulations and HCC. Inverse-variance weighting (IVW) served as the primary analysis method, with robustness validation through Bayesian weighted MR (BWMR) and machine learning algorithms. Therefore, for significantly associated immune subpopulations, independent analyses of gene expression, prognosis, and tumor immune microenvironment were conducted using HCC data from the Cancer Genome Atlas (TCGA) LIHC cohort. MR analysis and validation identified 21 immune cell subpopulations with significant causal associations to HCC risk. Among these, 12 were identified as risk factors, and 9 as protective factors. Validation in the TCGA cohort revealed that risk-associated immune subpopulations were predominantly enriched for markers of T cell exhaustion and immunosuppressive microenvironments, whereas protective subpopulations likely represented a distinct regulatory B cell subset whose function was associated with the anti-inflammatory factor interleukin-10. This study genetically confirms that specific immune cell functional subpopulations constitute causal risk factors for HCC. These subpopulations exert their effects by shaping distinct tumor immune microenvironments. These findings provide novel mechanisms for understanding the immunopathogenesis of HCC and identify potential targets for developing novel immune intervention strategies.
PMID:41366997 | DOI:10.1097/MD.0000000000045942
-
cs.AI, q-bio.NC updates on arXiv.org
-
Worse than Zero-shot? A Fact-Checking Dataset for Evaluating the Robustness of RAG Against Misleading Retrievals
arXiv:2502.16101v3 Announce Type: replace Abstract: Retrieval-augmented generation (RAG) has shown impressive capabilities in mitigating hallucinations in large language models (LLMs). However, LLMs struggle to maintain consistent reasoning when exposed to misleading or conflicting evidence, especially in real-world domains such as politics, where information is polarized or selectively framed. Mainstream RAG benchmarks evaluate models under clean retrieval settings, where systems generate answ
Worse than Zero-shot? A Fact-Checking Dataset for Evaluating the Robustness of RAG Against Misleading Retrievals
-
Journal of Medical Internet Research
-
The Impact of Digital Health Interventions on Psychological Health, Self-Efficacy, and Quality of Life in Patients With End-Stage Kidney Disease: Systematic Review and Meta-Analysis
Background: End-stage kidney disease (ESKD) imposes a significant global health burden, with patients often experiencing poor quality of life (QoL) due to psychological distress and low self-efficacy. Digital health interventions (DHIs) offer potential to address these challenges. However, their effects in this population remain inconsistent, and a comprehensive synthesis of the evidence is lacking. Objective: To assess the impact of DHIs on the psychological health, self-efficacy, and QoL of ES
The Impact of Digital Health Interventions on Psychological Health, Self-Efficacy, and Quality of Life in Patients With End-Stage Kidney Disease: Systematic Review and Meta-Analysis
-
Most Recent Articles: Clinical Epigenetics
-
Association between pace of biological aging and cancer and the modulating role of physical activity: a national cross-sectional study
Cancer remains a serious public health problem impeding gains in life expectancy. Epigenetic clocks, derived from sets of DNA methylation CpGs and mathematical algorithms, have demonstrated a remarkable abilit...
Association between pace of biological aging and cancer and the modulating role of physical activity: a national cross-sectional study
-
Cell Death Discovery nature.com science feeds
-
Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy
Cell Death Discovery, Published online: 01 April 2023; doi:10.1038/s41420-023-01407-zFerroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy
Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy
Cell Death Discovery, Published online: 01 April 2023; doi:10.1038/s41420-023-01407-z
Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy