arXiv:2601.06197v1 Announce Type: new Abstract: Generative AI has unleashed the power of content generation and it has also unwittingly opened the pandora box of realistic deepfake causing a number of social hazards and harm to businesses and personal reputation. The investigation & ramification of Generative AI technology across industries, the resolution & hybridization detection techniques using neural networks allows flagging of the content. Good detection techniques & flagging allow AI safety - this is the main focus of this paper. The research provides a significant method for efficiently detecting dark side problems by imposing a Temporal Consistency Learning (TCL) technique. Through pretrained Temporal Convolutional Networks (TCNs) model training and performance comparison, this paper showcases that TCN models outperforms the other approaches and achieves significant accuracy for five dark side problems. Findings highlight how important it is to take proactive measures in identification to reduce any potential risks associated with generative artificial intelligence.

arXiv:2601.06453v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly grounded in sensor data to perceive and reason about human physiology and the physical world. However, accurately interpreting heterogeneous multimodal sensor data remains a fundamental challenge. We show that a single monolithic LLM often fails to reason coherently across modalities, leading to incomplete interpretations and prior-knowledge bias. We introduce ConSensus, a training-free multi-agent collaboration framework that decomposes multimodal sensing tasks into specialized, modality-aware agents. To aggregate agent-level interpretations, we propose a hybrid fusion mechanism that balances semantic aggregation, which enables cross-modal reasoning and contextual understanding, with statistical consensus, which provides robustness through agreement across modalities. While each approach has complementary failure modes, their combination enables reliable inference under sensor noise and missing data. We evaluate ConSensus on five diverse multimodal sensing benchmarks, demonstrating an average accuracy improvement of 7.1% over the single-agent baseline. Furthermore, ConSensus matches or exceeds the performance of iterative multi-agent debate methods while achieving a 12.7 times reduction in average fusion token cost through a single-round hybrid fusion protocol, yielding a robust and efficient solution for real-world multimodal sensing tasks.

arXiv:2601.06060v1 Announce Type: cross Abstract: AI-generated "slop" is often seen as digital pollution. We argue that this dismissal of the topic risks missing important aspects of AI Slop that deserve rigorous study. AI Slop serves a social function: it offers a supply-side solution to a variety of problems in cultural and economic demand - that, collectively, people want more content than humans can supply. We also argue that AI Slop is not mere digital detritus but has its own aesthetic value. Like other "low" cultural forms initially dismissed by critics, it nonetheless offers a legitimate means of collective sense-making, with the potential to express meaning and identity. We identify three key features of family resemblance for prototypical AI Slop: superficial competence (its veneer of quality is belied by a deeper lack of substance), asymmetry effort (it takes vastly less effort to generate than would be the case without AI), and mass producibility (it is part of a digital ecosystem of widespread generation and consumption). While AI Slop is heterogeneous and depends crucially on its medium, it tends to vary across three dimensions: instrumental utility, personalization, and surrealism. AI Slop will be an increasingly prolific and impactful part of our creative, information, and cultural economies; we should take it seriously as an object of study in its own right.

arXiv:2601.06144v1 Announce Type: cross Abstract: Artificial intelligence (AI) in healthcare has led to many promising developments; however, increasingly, AI research is funded by the private sector leading to potential trade-offs between benefits to patients and benefits to industry. Health AI practitioners should prioritize successful adaptation into clinical practice in order to provide meaningful benefits to patients, but translation usually requires collaboration with industry. We discuss three features of AI studies that hamper the integration of AI into clinical practice from the perspective of researchers and clinicians. These include lack of clinically relevant metrics, lack of clinical trials and longitudinal studies to validate results, and lack of patient and physician involvement in the development process. For partnerships between industry and health research to be sustainable, a balance must be established between patient and industry benefit. We propose three approaches for addressing this gap: improved transparency and explainability of AI models, fostering relationships with industry partners that have a reputation for centering patient benefit in their practices, and prioritization of overall healthcare benefits. With these priorities, we can sooner realize meaningful AI technologies used by clinicians where mutua

arXiv:2601.06300v1 Announce Type: cross Abstract: Clinical trial amendments frequently introduce delays, increased costs, and administrative burden, with eligibility criteria being the most commonly amended component. We introduce \textit{eligibility criteria amendment prediction}, a novel NLP task that aims to forecast whether the eligibility criteria of an initial trial protocol will undergo future amendments. To support this task, we release $\texttt{AMEND++}$, a benchmark suite comprising two datasets: $\texttt{AMEND}$, which captures eligibility-criteria version histories and amendment labels from public clinical trials, and $\verb|AMEND_LLM|$, a refined subset curated using an LLM-based denoising pipeline to isolate substantive changes. We further propose $\textit{Change-Aware Masked Language Modeling}$ (CAMLM), a revision-aware pretraining strategy that leverages historical edits to learn amendment-sensitive representations. Experiments across diverse baselines show that CAMLM consistently improves amendment prediction, enabling more robust and cost-effective clinical trial design.

arXiv:2601.07136v1 Announce Type: cross Abstract: The rapid emergence of multi-agent AI systems (MAS), including LangChain, CrewAI, and AutoGen, has shaped how large language model (LLM) applications are developed and orchestrated. However, little is known about how these systems evolve and are maintained in practice. This paper presents the first large-scale empirical study of open-source MAS, analyzing over 42K unique commits and over 4.7K resolved issues across eight leading systems. Our analysis identifies three distinct development profiles: sustained, steady, and burst-driven. These profiles reflect substantial variation in ecosystem maturity. Perfective commits constitute 40.8% of all changes, suggesting that feature enhancement is prioritized over corrective maintenance (27.4%) and adaptive updates (24.3%). Data about issues shows that the most frequent concerns involve bugs (22%), infrastructure (14%), and agent coordination challenges (10%). Issue reporting also increased sharply across all frameworks starting in 2023. Median resolution times range from under one day to about two weeks, with distributions skewed toward fast responses but a minority of issues requiring extended attention. These results highlight both the momentum and the fragility of the current ecosystem, emphasizing the need for improved testing infrastructure, documentation quality, and maintenance practices to ensure long-term reliability and sustainability.

arXiv:2504.14523v2 Announce Type: replace Abstract: Training models on synthetic data has emerged as an increasingly important strategy for improving the performance of generative AI. This approach is particularly helpful for large multimodal models (LMMs) due to the relative scarcity of high-quality paired image-text data compared to language-only data. While a variety of methods have been proposed for generating large multimodal datasets, they do not tailor the synthetic data to address specific deficiencies in the reasoning abilities of LMMs which will be trained with the generated dataset. In contrast, humans often learn in a more efficient manner by seeking out examples related to the types of reasoning where they have failed previously. Inspired by this observation, we propose a new approach for synthetic data generation which is grounded in the analysis of an existing LMM's reasoning failures. Our methodology leverages frontier models to automatically analyze errors produced by a weaker LMM and propose new examples which can be used to correct the reasoning failure via additional training, which are then further filtered to ensure high quality. We generate a large multimodal instruction tuning dataset containing over 553k examples using our approach and conduct extensive experiments demonstrating its utility for improving the performance of LMMs on multiple downstream tasks. Our results show that models trained on our synthetic data can even exceed the performance of LMMs trained on an equivalent amount of additional real data, demonstrating the high value of generating synthetic data targeted to specific reasoning failure modes in LMMs. We will make our dataset and code publicly available.

arXiv:2505.19562v2 Announce Type: replace Abstract: Large language models (LLMs) are approaching expert-level performance in medical question answering (QA), demonstrating strong potential to improve public healthcare. However, underlying biases related to sensitive attributes such as sex and race pose life-critical risks. The extent to which such sensitive attributes affect diagnosis remains an open question and requires comprehensive empirical investigation. Additionally, even the latest Counterfactual Patient Variations (CPV) benchmark can hardly distinguish the bias levels of different LLMs. To further explore these dynamics, we propose a new benchmark, FairMedQA, and benchmark 12 representative LLMs. FairMedQA contains 4,806 counterfactual question pairs constructed from 801 clinical vignettes. Our results reveal substantial accuracy disparity ranging from 3 to 19 percentage points across sensitive demographic groups. Notably, FairMedQA exposes biases that are at least 12 percentage points larger than those identified by the latest CPV benchmark, presenting superior benchmarking sensitivity. Our results underscore an urgent need for targeted debiasing techniques and more rigorous, identity-aware validation protocols before LLMs can be safely integrated into practical clinical decision-support systems.

arXiv:2511.19577v2 Announce Type: replace Abstract: Chronic pain (CP) and opioid use disorder (OUD) are common and interrelated chronic medical conditions. Currently, there is a paucity of evidence-based integrated treatments for CP and OUD among individuals receiving medication for opioid use disorder (MOUD). Wearable devices have the potential to monitor complex patient information and inform treatment development for persons with OUD and CP, including pain variability (e.g., exacerbations of pain or pain spikes) and clinical correlates (e.g., perceived stress). However, the application of large language models (LLMs) with wearable data for understanding pain spikes, remains unexplored. Consequently, the aim of this pilot study was to examine the clinical correlates of pain spikes using a range of AI approaches. We found that machine learning models achieved relatively high accuracy (>0.7) in predicting pain spikes, while LLMs were limited in providing insights on pain spikes. Real-time monitoring through wearable devices, combined with advanced AI models, could facilitate early detection of pain spikes and support personalized interventions that may help mitigate the risk of opioid relapse, improve adherence to MOUD, and enhance the integration of CP and OUD care. Given overall limited LLM performance, these findings highlight the need to develop LLMs which can provide actionable insights in the OUD/CP context.

arXiv:2501.17414v2 Announce Type: replace-cross Abstract: Although machine learning (ML) shows potential in improving query optimization by generating and selecting more efficient plans, ensuring the robustness of learning-based cost models (LCMs) remains challenging. These LCMs currently lack explainability, which undermines user trust and limits the ability to derive insights from their cost predictions to improve plan quality. Accurately converting tree-structured query plans into representations via tree models is also essential, as omitting any details may negatively impact subsequent cost model performance. Additionally, inherent uncertainty in cost estimation leads to inaccurate predictions, resulting in suboptimal plan selection. To address these challenges, we introduce Reqo, a Robust and Explainable Query Optimization cost model that comprehensively enhances three main stages in query optimization: plan generation, plan representation, and plan selection. Reqo integrates three innovations: the first explainability technique for LCMs that quantifies subgraph contributions and produces plan generation hints to enhance candidate plan quality; a novel tree model based on Bidirectional Graph Neural Networks (Bi-GNNs) with a Gated Recurrent Unit (GRU) aggregator to further capture both node-level and structural information and effectively strengthen plan representation; and an uncertainty-aware learning-to-rank cost estimator that adaptively integrates cost estimates with uncertainties to enhance plan selection robustness. Extensive experiments demonstrate that Reqo outperforms state-of-the-art approaches across all three stages.

Anthropic's Claude for Healthcare is unveiled about a week after OpenAI announced its ChatGPT Health product.

Background: Artificial Intelligence (AI)-enabled devices are increasingly used in healthcare. However, there has been limited research on patients’ informational preferences, including which elements of AI device labeling enhance patient understanding, trust, and acceptance. Clear and effective patient-facing communication is essential to address patient concerns and support informed decision-making regarding AI-enabled care. Objective: Using simulated AI device labels in a cardiovascular context, we evaluated three aims. First, we identified key information elements that influence patient trust and acceptance of an AI device. Second, we examined how these effects varied based on patient characteristics. Third, we explored how patients evaluated informational content of AI labels and their perceived effectiveness of the AI labels in informing decision-making about the use of AI device, building trust in the device, and shaping their intention to use it in their healthcare. Methods: We recruited 340 US patients from ResearchMatch.org to participate in a web-based survey that contained two experiments. In the discrete choice experiment (DCE), participants indicated preferences in terms of trust and acceptance regarding 16 pairs of simulated AI device labels that varied across eight types of information needs identified in our previous qualitative work. In the single profile factorial experiment (SPFE), participants evaluated four randomly assigned label prototypes regarding the label’s legibility, comprehensibility, information overload, credibility, and perceived effectiveness in informing about the AI device, as well as participants’ trust in the AI device and intention to use the device in their healthcare. Data was analyzed using mixed effects binary or ordinal logistic regression. Results: The DCE showed that information about regulatory approval, high device performance, provider oversight, and AI’s value added to usual care significantly increased the likelihood of patient trust by 14.1-19.3% and acceptance by 13.3-17.9%. Subgroup analyses revealed variations based on patient characteristics such as familiarity with AI, health literacy, and recency of last medical checkup. The SPFE showed that patients reported good label comprehension, and that information about provider oversight, regulatory approval, device performance, and AI’s added value improved perceived credibility and effectiveness of the AI label (odds ratios [ORs] range 1.35-2.05), reduced doubts in the AI device (ORs range 0.61- 0.77), and increased trust and intention to use the AI device (ORs range 1.47-1.73). However, information about data privacy and safety management protocols are less influential. Conclusions: Patients value information about an AI device’s performance, provider oversight, regulatory status, and added value during decision-making. Providing transparent, easily understandable information about these aspects is critical to support patient determinations of trust and acceptance of AI-enabled healthcare. Information elements’ impact on patient trust and acceptance varies by patient characteristics, highlighting the need for a tailored approach to address the concerns of diverse patient groups about AI in healthcare.

Nature Medicine, Published online: 12 January 2026; doi:10.1038/s41591-025-04126-3

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

arXiv:2601.05500v1 Announce Type: new Abstract: Benchmarking the relative capabilities of AI systems, including Large Language Models (LLMs) and Vision Models, typically ignores the impact of uncertainty in the underlying ground truth answers from experts. This ambiguity is particularly consequential in medicine where uncertainty is pervasive. In this paper, we introduce a probabilistic paradigm to theoretically explain how high certainty in ground truth answers is almost always necessary for even an expert to achieve high scores, whereas in datasets with high variation in ground truth answers there may be little difference between a random labeller and an expert. Therefore, ignoring uncertainty in ground truth evaluation data can result in the misleading conclusion that a non-expert has similar performance to that of an expert. Using the probabilistic paradigm, we thus bring forth the concepts of expected accuracy and expected F1 to estimate the score an expert human or system can achieve given ground truth answer variability. Our work leads to the recommendation that when establishing the capability of a system, results should be stratified by probability of the ground truth answer, typically measured by the agreement rate of ground truth experts. Stratification becomes critical when the overall performance drops below a threshold of 80%. Under stratified evaluation, performance comparison becomes more reliable in high certainty bins, mitigating the effect of the key confounding factor -- uncertainty.

arXiv:2601.05293v1 Announce Type: cross Abstract: Agentic AI marks an important transition from single-step generative models to systems capable of reasoning, planning, acting, and adapting over long-lasting tasks. By integrating memory, tool use, and iterative decision cycles, these systems enable continuous, autonomous workflows in real-world environments. This survey examines the implications of agentic AI for cybersecurity. On the defensive side, agentic capabilities enable continuous monitoring, autonomous incident response, adaptive threat hunting, and fraud detection at scale. Conversely, the same properties amplify adversarial power by accelerating reconnaissance, exploitation, coordination, and social-engineering attacks. These dual-use dynamics expose fundamental gaps in existing governance, assurance, and accountability mechanisms, which were largely designed for non-autonomous and short-lived AI systems. To address these challenges, we survey emerging threat models, security frameworks, and evaluation pipelines tailored to agentic systems, and analyze systemic risks including agent collusion, cascading failures, oversight evasion, and memory poisoning. Finally, we present three representative use-case implementations that illustrate how agentic AI behaves in practical cybersecurity workflows, and how design choices shape reliability, safety, and operational effectiveness.

Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04170-z

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04171-y

In a randomized, double-blind, placebo-controlled trial comparing autologous mRNA-engineered BCMA-targeting CAR T cell therapy versus placebo in patients with generalized myasthenia gravis, a significantly higher percentage of patients exhibited a reduction in disease activity in the treatment arm than in the placebo arm.

arXiv:2601.04577v1 Announce Type: new Abstract: While AI innovation accelerates rapidly, the intellectual process behind breakthroughs -- how researchers identify gaps, synthesize prior work, and generate insights -- remains poorly understood. The lack of structured data on scientific reasoning hinders systematic analysis and development of AI research agents. We introduce Sci-Reasoning, the first dataset capturing the intellectual synthesis behind high-quality AI research. Using community-validated quality signals and an LLM-accelerated, human-verified pipeline, we trace Oral and Spotlight papers across NeurIPS, ICML, and ICLR (2023-2025) to its key predecessors, articulating specific reasoning links in a structured format. Our analysis identifies 15 distinct thinking patterns, with three dominant strategies accounting for 52.7%: Gap-Driven Reframing (24.2%), Cross-Domain Synthesis (18.0%), and Representation Shift (10.5%). The most powerful innovation recipes combine multiple patterns: Gap-Driven Reframing + Representation Shift, Cross-Domain Synthesis + Representation Shift, and Gap-Driven Reframing + Cross-Domain Synthesis. This dataset enables quantitative studies of scientific progress and provides structured reasoning trajectories for training the next generation AI research agents.

arXiv:2601.04703v1 Announce Type: new Abstract: Agentic search has emerged as a promising paradigm for complex information seeking by enabling Large Language Models (LLMs) to interleave reasoning with tool use. However, prevailing systems rely on monolithic agents that suffer from structural bottlenecks, including unconstrained reasoning outputs that inflate trajectories, sparse outcome-level rewards that complicate credit assignment, and stochastic search noise that destabilizes learning. To address these challenges, we propose \textbf{M-ASK} (Multi-Agent Search and Knowledge), a framework that explicitly decouples agentic search into two complementary roles: Search Behavior Agents, which plan and execute search actions, and Knowledge Management Agents, which aggregate, filter, and maintain a compact internal context. This decomposition allows each agent to focus on a well-defined subtask and reduces interference between search and context construction. Furthermore, to enable stable coordination, M-ASK employs turn-level rewards to provide granular supervision for both search decisions and knowledge updates. Experiments on multi-hop QA benchmarks demonstrate that M-ASK outperforms strong baselines, achieving not only superior answer accuracy but also significantly more stable training dynamics.\footnote{The source code for M-ASK is available at https://github.com/chenyiqun/M-ASK.}