arXiv:2601.08333v1 Announce Type: new Abstract: LLM-based agent architectures systematically conflate information transport mechanisms with epistemic justification mechanisms. We formalize this class of architectural failures as semantic laundering: a pattern where propositions with absent or weak warrant are accepted by the system as admissible by crossing architecturally trusted interfaces. We show that semantic laundering constitutes an architectural realization of the Gettier problem: propositions acquire high epistemic status without a connection between their justification and what makes them true. Unlike classical Gettier cases, this effect is not accidental; it is architecturally determined and systematically reproducible. The central result is the Theorem of Inevitable Self-Licensing: under standard architectural assumptions, circular epistemic justification cannot be eliminated. We introduce the Warrant Erosion Principle as the fundamental explanation for this effect and show that scaling, model improvement, and LLM-as-judge schemes are structurally incapable of eliminating a problem that exists at the type level.

arXiv:2601.08559v1 Announce Type: new Abstract: Sustainable water resource management in transboundary river basins is challenged by fragmented data, limited real-time access, and the complexity of integrating diverse information sources. This paper presents WaterCopilot-an AI-driven virtual assistant developed through collaboration between the International Water Management Institute (IWMI) and Microsoft Research for the Limpopo River Basin (LRB) to bridge these gaps through a unified, interactive platform. Built on Retrieval-Augmented Generation (RAG) and tool-calling architectures, WaterCopilot integrates static policy documents and real-time hydrological data via two custom plugins: the iwmi-doc-plugin, which enables semantic search over indexed documents using Azure AI Search, and the iwmi-api-plugin, which queries live databases to deliver dynamic insights such as environmental-flow alerts, rainfall trends, reservoir levels, water accounting, and irrigation data. The system features guided multilingual interactions (English, Portuguese, French), transparent source referencing, automated calculations, and visualization capabilities. Evaluated using the RAGAS framework, WaterCopilot achieves an overall score of 0.8043, with high answer relevancy (0.8571) and context precision (0.8009). Key innovations include automated threshold-based alerts, integration with the LRB Digital Twin, and a scalable deployment pipeline hosted on AWS. While limitations in processing non-English technical documents and API latency remain, WaterCopilot establishes a replicable AI-augmented framework for enhancing water governance in data-scarce, transboundary contexts. The study demonstrates the potential of this AI assistant to support informed, timely decision-making and strengthen water security in complex river basins.

arXiv:2601.08690v1 Announce Type: new Abstract: Conversational AI is starting to support real clinical work, but most evaluation methods miss how compliance depends on the full course of a conversation. We introduce Obligatory-Information Phase Structured Compliance Evaluation (OIP-SCE), an evaluation method that checks whether every required clinical obligation is met, in the right order, with clear evidence for clinicians to review. This makes complex rules practical and auditable, helping close the gap between technical progress and what healthcare actually needs. We demonstrate the method in two case studies (respiratory history, benefits verification) and show how phase-level evidence turns policy into shared, actionable steps. By giving clinicians control over what to check and engineers a clear specification to implement, OIP-SCE provides a single, auditable evaluation surface that aligns AI capability with clinical workflow and supports routine, safe use.

arXiv:2601.08183v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) show promise in gastroenterology, yet their performance against comprehensive clinical workflows and human benchmarks remains unverified. To systematically evaluate state-of-the-art MLLMs across a panoramic gastrointestinal endoscopy workflow and determine their clinical utility compared with human endoscopists. We constructed GI-Bench, a benchmark encompassing 20 fine-grained lesion categories. Twelve MLLMs were evaluated across a five-stage clinical workflow: anatomical localization, lesion identification, diagnosis, findings description, and management. Model performance was benchmarked against three junior endoscopists and three residency trainees using Macro-F1, mean Intersection-over-Union (mIoU), and multi-dimensional Likert scale. Gemini-3-Pro achieved state-of-the-art performance. In diagnostic reasoning, top-tier models (Macro-F1 0.641) outperformed trainees (0.492) and rivaled junior endoscopists (0.727; p>0.05). However, a critical "spatial grounding bottleneck" persisted; human lesion localization (mIoU >0.506) significantly outperformed the best model (0.345; p

arXiv:2601.08634v1 Announce Type: cross Abstract: While recent research has systematically documented political orientation in large language models (LLMs), existing evaluations rely primarily on direct probing or demographic persona engineering to surface ideological biases. In social psychology, however, political ideology is also understood as a downstream consequence of fundamental moral intuitions. In this work, we investigate the causal relationship between moral values and political positioning by treating moral orientation as a controllable condition. Rather than simply assigning a demographic persona, we condition models to endorse or reject specific moral values and evaluate the resulting shifts on their political orientations, using the Political Compass Test. By treating moral values as lenses, we observe how moral conditioning actively steers model trajectories across economic and social dimensions. Our findings show that such conditioning induces pronounced, value-specific shifts in models' political coordinates. We further notice that these effects are systematically modulated by role framing and model scale, and are robust across alternative assessment instruments instantiating the same moral value. This highlights that effective alignment requires anchoring political assessments within the context of broader social values including morality, paving the way for more socially grounded alignment techniques.

arXiv:2601.08732v1 Announce Type: cross Abstract: Accurate delineation of acute ischemic stroke lesions in MRI is a key component of stroke diagnosis and management. In recent years, deep learning models have been successfully applied to the automatic segmentation of such lesions. While most proposed architectures are based on the U-Net framework, they primarily differ in their choice of loss functions and in the use of deep supervision, residual connections, and attention mechanisms. Moreover, many implementations are not publicly available, and the optimal configuration for acute ischemic stroke (AIS) lesion segmentation remains unclear. In this work, we introduce ISLA (Ischemic Stroke Lesion Analyzer), a new deep learning model for AIS lesion segmentation from diffusion MRI, trained on three multicenter databases totaling more than 1500 AIS participants. Through systematic optimization of the loss function, convolutional architecture, deep supervision, and attention mechanisms, we developed a robust segmentation framework. We further investigated unsupervised domain adaptation to improve generalization to an external clinical dataset. ISLA outperformed two state-of-the-art approaches for AIS lesion segmentation on an external test set. Codes and trained models will be made publicly available to facilitate reuse and reproducibility.

arXiv:2509.14507v2 Announce Type: replace Abstract: Natural Language to SQL (NL2SQL) provides a new model-centric paradigm that simplifies database access for non-technical users by converting natural language queries into SQL commands. Recent advancements, particularly those integrating Retrieval-Augmented Generation (RAG) and Chain-of-Thought (CoT) reasoning, have made significant strides in enhancing NL2SQL performance. However, challenges such as inaccurate task decomposition and keyword extraction by LLMs remain major bottlenecks, often leading to errors in SQL generation. While existing datasets aim to mitigate these issues by fine-tuning models, they struggle with over-fragmentation of tasks and lack of domain-specific keyword annotations, limiting their effectiveness. To address these limitations, we present DeKeyNLU, a novel dataset which contains 1,500 meticulously annotated QA pairs aimed at refining task decomposition and enhancing keyword extraction precision for the RAG pipeline. Fine-tuned with DeKeyNLU, we propose DeKeySQL, a RAG-based NL2SQL pipeline that employs three distinct modules for user question understanding, entity retrieval, and generation to improve SQL generation accuracy. We benchmarked multiple model configurations within DeKeySQL RAG pipeline. Experimental results demonstrate that fine-tuning with DeKeyNLU significantly improves SQL generation accuracy on both BIRD (62.31% to 69.10%) and Spider (84.2% to 88.7%) dev datasets.

arXiv:2512.20387v4 Announce Type: replace Abstract: We propose a Vision-Language Simulation Model (VLSM) that unifies visual and textual understanding to synthesize executable FlexScript from layout sketches and natural-language prompts, enabling cross-modal reasoning for industrial simulation systems. To support this new paradigm, the study constructs the first large-scale dataset for generative digital twins, comprising over 120,000 prompt-sketch-code triplets that enable multimodal learning between textual descriptions, spatial structures, and simulation logic. In parallel, three novel evaluation metrics, Structural Validity Rate (SVR), Parameter Match Rate (PMR), and Execution Success Rate (ESR), are proposed specifically for this task to comprehensively evaluate structural integrity, parameter fidelity, and simulator executability. Through systematic ablation across vision encoders, connectors, and code-pretrained language backbones, the proposed models achieve near-perfect structural accuracy and high execution robustness. This work establishes a foundation for generative digital twins that integrate visual reasoning and language understanding into executable industrial simulation systems. Project page: https://danielhsu2014.github.io/GDT-VLSM-project/

arXiv:2405.16041v4 Announce Type: replace-cross Abstract: Providing explainable molecular property predictions is critical for many scientific domains, such as drug discovery and material science. Though transformer-based language models have shown great potential in accurate molecular property prediction, they neither provide chemically meaningful explanations nor faithfully reveal the molecular structure-property relationships. In this work, we develop a framework for explainable molecular property prediction based on language models, dubbed as Lamole, which can provide chemical concepts-aligned explanations. We take a string-based molecular representation -- Group SELFIES -- as input tokens to pretrain and fine-tune our Lamole, as it provides chemically meaningful semantics. By disentangling the information flows of Lamole, we propose combining self-attention weights and gradients for better quantification of each chemically meaningful substructure's impact on the model's output. To make the explanations more faithfully respect the structure-property relationship, we then carefully craft a marginal loss to explicitly optimize the explanations to be able to align with the chemists' annotations. We bridge the manifold hypothesis with the elaborated marginal loss to prove that the loss can align the explanations with the tangent space of the data manifold, leading to concept-aligned explanations. Experimental results over six mutagenicity datasets and one hepatotoxicity dataset demonstrate Lamole can achieve comparable classification accuracy and boost the explanation accuracy by up to 14.3%, being the state-of-the-art in explainable molecular property prediction.

arXiv:2504.08526v2 Announce Type: replace-cross Abstract: Generative AI increasingly supports scientific inference, from protein structure prediction to weather forecasting. Yet its distinctive failure mode, hallucination, raises epistemic alarm bells. I argue that this failure mode can be addressed by shifting from data-centric to phenomenon-centric assessment. Through case studies of AlphaFold and GenCast, I show how scientific workflows discipline generative models through theory-guided training and confidence-based error screening. These strategies convert hallucination from an unmanageable epistemic threat into bounded risk. When embedded in such workflows, generative models support reliable inference despite opacity, provided they operate in theoretically mature domains.

arXiv:2505.07917v2 Announce Type: replace-cross Abstract: Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for biomedical QA, evaluating retrieval strategies and response time trade-offs. We first assess state-of-the-art retrieval methods, including BM25, BioBERT, MedCPT, and a hybrid approach, alongside common data stores such as Elasticsearch, MongoDB, and FAISS, on a ~10% subset of PubMed (2.4M documents) to measure indexing efficiency, retrieval latency, and retriever performance in the end-to-end RAG system. Based on these insights, we deploy the final RAG system on the full 24M PubMed corpus, comparing different retrievers' impact on overall performance. Evaluations of the retrieval depth show that retrieving 50 documents with BM25 before reranking with MedCPT optimally balances accuracy (0.90), recall (0.90), and response time (1.91s). BM25 retrieval time remains stable (82ms), while MedCPT incurs the main computational cost. These results highlight previously not well-known trade-offs in retrieval depth, efficiency, and scalability for biomedical QA. With open-source code, the system is fully reproducible and extensible.

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The next test for Kite Pharma — and Gilead

It’s anito-cel, the CAR-T therapy for multiple myeloma that Gilead is developing in partnership with Arcellx. Gilead submitted the therapy to the FDA sometime before the end of December, Cindy Perettie, executive vice president of Kite Pharma, the cell therapy division of Gilead, told STAT at a Gilead media breakfast.

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npj Digital Medicine, Published online: 13 January 2026; doi:10.1038/s41746-025-02287-6

Geometric multi-instance learning for weakly supervised gastric cancer segmentation

arXiv:2601.06663v1 Announce Type: new Abstract: Large language model-based agents are rapidly evolving from simple conversational assistants into autonomous systems capable of performing complex, professional-level tasks in various domains. While these advancements promise significant productivity gains, they also introduce critical safety risks that remain under-explored. Existing safety evaluations primarily focus on simple, daily assistance tasks, failing to capture the intricate decision-making processes and potential consequences of misaligned behaviors in professional settings. To address this gap, we introduce \textbf{SafePro}, a comprehensive benchmark designed to evaluate the safety alignment of AI agents performing professional activities. SafePro features a dataset of high-complexity tasks across diverse professional domains with safety risks, developed through a rigorous iterative creation and review process. Our evaluation of state-of-the-art AI models reveals significant safety vulnerabilities and uncovers new unsafe behaviors in professional contexts. We further show that these models exhibit both insufficient safety judgment and weak safety alignment when executing complex professional tasks. In addition, we investigate safety mitigation strategies for improving agent safety in these scenarios and observe encouraging improvements. Together, our findings highlight the urgent need for robust safety mechanisms tailored to the next generation of professional AI agents.

arXiv:2601.07233v1 Announce Type: new Abstract: Explainable AI (XAI) in high-stakes domains should help stakeholders trust and verify system outputs. Yet Chain-of-Thought methods reason before concluding, and logical gaps or hallucinations can yield conclusions that do not reliably align with their rationale. Thus, we propose "Result -> Justify", which constrains the output communication to present a conclusion before its structured justification. We introduce SEF (Structured Explainability Framework), operationalizing professional conventions (e.g., CREAC, BLUF) via six metrics for structure and grounding. Experiments across four tasks in three domains validate this approach: all six metrics correlate with correctness (r=0.20-0.42; p

arXiv:2601.07463v1 Announce Type: new Abstract: Offline multi-agent reinforcement learning (MARL) aims to solve cooperative decision-making problems in multi-agent systems using pre-collected datasets. Existing offline MARL methods primarily constrain training within the dataset distribution, resulting in overly conservative policies that struggle to generalize beyond the support of the data. While model-based approaches offer a promising solution by expanding the original dataset with synthetic data generated from a learned world model, the high dimensionality, non-stationarity, and complexity of multi-agent systems make it challenging to accurately estimate the transitions and reward functions in offline MARL. Given the difficulty of directly modeling joint dynamics, we propose a local-to-global (LOGO) world model, a novel framework that leverages local predictions-which are easier to estimate-to infer global state dynamics, thus improving prediction accuracy while implicitly capturing agent-wise dependencies. Using the trained world model, we generate synthetic data to augment the original dataset, expanding the effective state-action space. To ensure reliable policy learning, we further introduce an uncertainty-aware sampling mechanism that adaptively weights synthetic data by prediction uncertainty, reducing approximation error propagation to policies. In contrast to conventional ensemble-based methods, our approach requires only an additional encoder for uncertainty estimation, significantly reducing computational overhead while maintaining accuracy. Extensive experiments across 8 scenarios against 8 baselines demonstrate that our method surpasses state-of-the-art baselines on standard offline MARL benchmarks, establishing a new model-based baseline for generalizable offline multi-agent learning.

arXiv:2601.06030v1 Announce Type: cross Abstract: This paper offers a concise, 60-year synthesis of human-AI collaboration, from Licklider's ``man-computer symbiosis" (AI as colleague) and Engelbart's ``augmenting human intellect" (AI as tool) to contemporary poles: Human-Centered AI's ``supertool" and Symbiotic Intelligence's mutual-adaptation model. We formalize the mechanism for effective teaming as a causal chain: Explainable AI (XAI) -> co-adaptation -> shared mental models (SMMs). A meta-analytic ``performance paradox" is then examined: human-AI teams tend to show negative synergy in judgment/decision tasks (underperforming AI alone) but positive synergy in content creation and problem formulation. We trace failures to the algorithm-in-the-loop dynamic, aversion/bias asymmetries, and cumulative cognitive deskilling. We conclude with a unifying framework--combining extended-self and dual-process theories--arguing that durable gains arise when AI functions as an internalized cognitive component, yielding a unitary human-XAI symbiotic agency. This resolves the paradox and delineates a forward agenda for research and practice.

arXiv:2601.06060v1 Announce Type: cross Abstract: AI-generated "slop" is often seen as digital pollution. We argue that this dismissal of the topic risks missing important aspects of AI Slop that deserve rigorous study. AI Slop serves a social function: it offers a supply-side solution to a variety of problems in cultural and economic demand - that, collectively, people want more content than humans can supply. We also argue that AI Slop is not mere digital detritus but has its own aesthetic value. Like other "low" cultural forms initially dismissed by critics, it nonetheless offers a legitimate means of collective sense-making, with the potential to express meaning and identity. We identify three key features of family resemblance for prototypical AI Slop: superficial competence (its veneer of quality is belied by a deeper lack of substance), asymmetry effort (it takes vastly less effort to generate than would be the case without AI), and mass producibility (it is part of a digital ecosystem of widespread generation and consumption). While AI Slop is heterogeneous and depends crucially on its medium, it tends to vary across three dimensions: instrumental utility, personalization, and surrealism. AI Slop will be an increasingly prolific and impactful part of our creative, information, and cultural economies; we should take it seriously as an object of study in its own right.

arXiv:2601.06153v1 Announce Type: cross Abstract: This policy report draws on country studies from China, South Korea, Singapore, and the United Kingdom to identify effective tools and key barriers to interoperability in AI safety governance. It offers practical recommendations to support a globally informed yet locally grounded governance ecosystem. Interoperability is a central goal of AI governance, vital for reducing risks, fostering innovation, enhancing competitiveness, promoting standardization, and building public trust. However, structural gaps such as fragmented regulations and lack of global coordination, and conceptual gaps, including limited Global South engagement, continue to hinder progress. Focusing on three high-stakes domains - autonomous vehicles, education, and cross-border data flows - the report compares ethical, legal, and technical frameworks across the four countries. It identifies areas of convergence, divergence, and potential alignment, offering policy recommendations that support the development of interoperability mechanisms aligned with the Global Digital Compact and relevant UN resolutions. The analysis covers seven components: objectives, regulators, ethics, binding measures, targeted frameworks, technical standards, and key risks.

arXiv:2601.06223v1 Announce Type: cross Abstract: This paper presents a conceptual and operational framework for developing and operating safe and trustworthy AI agents based on a Three-Pillar Model grounded in transparency, accountability, and trustworthiness. Building on prior work in Human-in-the-Loop systems, reinforcement learning, and collaborative AI, the framework defines an evolutionary path toward autonomous agents that balances increasing automation with appropriate human oversight. The paper argues that safe agent autonomy must be achieved through progressive validation, analogous to the staged development of autonomous driving, rather than through immediate full automation. Transparency and accountability are identified as foundational requirements for establishing user trust and for mitigating known risks in generative AI systems, including hallucinations, data bias, and goal misalignment, such as the inversion problem. The paper further describes three ongoing work streams supporting this framework: public deliberation on AI agents conducted by the Stanford Deliberative Democracy Lab, cross-industry collaboration through the Safe AI Agent Consortium, and the development of open tooling for an agent operating environment aligned with the Three-Pillar Model. Together, these contributions provide both conceptual clarity and practical guidance for enabling the responsible evolution of AI agents that operate transparently, remain aligned with human values, and sustain societal trust.