Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Deployability-Centric Infrastructure-as-Code Generation: Fail, Learn, Refine, and Succeed through LLM-Empowered DevOps Simulation
arXiv:2506.05623v2 Announce Type: replace-cross Abstract: Infrastructure-as-Code (IaC) generation holds significant promise for automating cloud infrastructure provisioning. Recent advances in Large Language Models (LLMs) present a promising opportunity to democratize IaC development by generating deployable infrastructure templates from natural language descriptions. However, current evaluation focuses on syntactic correctness while ignoring deployability, the critical measure of the utility o
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(Multiomics OR Omics) AND (Pancreatic)
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High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis
bioRxiv [Preprint]. 2025 May 5:2025.05.01.651678. doi: 10.1101/2025.05.01.651678.ABSTRACTPancreatic cancer remains as one of the most challenging malignancies to diagnose and treat due to the late development of symptoms and limited early diagnostic options. Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursors to invasive pancreatic ductal adenocarcinoma (PDAC)and an understanding of the changes in patterns of protein expression that accompany the progression from normal
High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis
bioRxiv [Preprint]. 2025 May 5:2025.05.01.651678. doi: 10.1101/2025.05.01.651678.
ABSTRACT
Pancreatic cancer remains as one of the most challenging malignancies to diagnose and treat due to the late development of symptoms and limited early diagnostic options. Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursors to invasive pancreatic ductal adenocarcinoma (PDAC)and an understanding of the changes in patterns of protein expression that accompany the progression from normal ductal (ND) cell, to IPMN to PDAC may provide avenues for improved earlier detection. In this study, we present an optimized spatial tissue proteomics workflow, termed SP-Max (Spatial Proteomics Optimized for Maximum Sensitivity and Reproducibility in Minimal Sample), designed to maximize protein recovery and quantification from limited laser micro dissected (LMD) samples. Our workflow enabled the identification of more than 6,000 proteins and the quantification of over 5,200 protein groups from FFPE tissue contours of pancreatic tissues. Comparative analyses across ND, IPMN, and PDAC revealed critical molecular differences in protein pathways and potential markers of progression. SP-Max provides a systematic, reproducible approach that significantly enhances our ability to study precancerous lesions and cancer progression in pancreatic tissues at unprecedented resolution.
PMID:40654937 | PMC:PMC12247709 | DOI:10.1101/2025.05.01.651678
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Cell Death Discovery nature.com science feeds
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Ferroptosis: a new hunter of hepatocellular carcinoma
Cell Death Discovery, Published online: 13 March 2024; doi:10.1038/s41420-024-01863-1Ferroptosis: a new hunter of hepatocellular carcinoma
Ferroptosis: a new hunter of hepatocellular carcinoma
Cell Death Discovery, Published online: 13 March 2024; doi:10.1038/s41420-024-01863-1
Ferroptosis: a new hunter of hepatocellular carcinoma