Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Chatbot To Help Patients Understand Their Health
arXiv:2509.05818v2 Announce Type: replace Abstract: Patients must possess the knowledge necessary to actively participate in their care. We present NoteAid-Chatbot, a conversational AI that promotes patient understanding via a novel 'learning as conversation' framework, built on a multi-agent large language model (LLM) and reinforcement learning (RL) setup without human-labeled data. NoteAid-Chatbot was built on a lightweight LLaMA 3.2 3B model trained in two stages: initial supervised fine-tun
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cs.AI, q-bio.NC updates on arXiv.org
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VaultGemma: A Differentially Private Gemma Model
arXiv:2510.15001v2 Announce Type: replace-cross Abstract: We introduce VaultGemma 1B, a 1 billion parameter model within the Gemma family, fully trained with differential privacy. Pretrained on the identical data mixture used for the Gemma 2 series, VaultGemma 1B represents a significant step forward in privacy-preserving large language models. We openly release this model to the community
VaultGemma: A Differentially Private Gemma Model
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Nature - Issue - nature.com science feeds
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Pre-rRNA spatial distribution and functional organization of the nucleolus
Nature, Published online: 23 July 2025; doi:10.1038/s41586-025-09412-1Pre-rRNA spatial distribution and functional organization of the nucleolus
Pre-rRNA spatial distribution and functional organization of the nucleolus
Nature, Published online: 23 July 2025; doi:10.1038/s41586-025-09412-1
Pre-rRNA spatial distribution and functional organization of the nucleolus-
Most Recent Articles: Clinical Epigenetics
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A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma
Childhood asthma presents a multifaceted immune-driven pathology shaped by genetic, epigenetic, and immune regulatory interactions. Despite extensive genome-wide analyses pinpointing multiple susceptibility lo...
A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma
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(Multiomics OR Omics) AND (Pancreatic)
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Efficient discovery of robust prognostic biomarkers and signatures in solid tumors
Cancer Lett. 2025 Mar 31;613:217502. doi: 10.1016/j.canlet.2025.217502. Epub 2025 Jan 24.ABSTRACTRecent advancements in multi-omics and big-data technologies have facilitated the discovery of numerous cancer prognostic biomarkers and gene signatures. However, their clinical application remains limited due to poor reproducibility and insufficient independent validation. Despite the availability of high-quality datasets, achieving reliable biomarker identification across multiple cohorts continues
Efficient discovery of robust prognostic biomarkers and signatures in solid tumors
Cancer Lett. 2025 Mar 31;613:217502. doi: 10.1016/j.canlet.2025.217502. Epub 2025 Jan 24.
ABSTRACT
Recent advancements in multi-omics and big-data technologies have facilitated the discovery of numerous cancer prognostic biomarkers and gene signatures. However, their clinical application remains limited due to poor reproducibility and insufficient independent validation. Despite the availability of high-quality datasets, achieving reliable biomarker identification across multiple cohorts continues to be a significant challenge. To address these issues, we developed a comprehensive platform, SurvivalML, designed to support the discovery and validation of prognostic biomarkers and gene signatures using large-scale and harmonized data from 21 cancer types. Through SurvivalML, we identified DCLRE1B as a novel prognostic biomarker for hepatocellular carcinoma, with experimental confirmation of its role in promoting tumor progression. Additionally, we developed the Chinese glioblastoma prognostic signature (CGPS) and its simplified version, SCGPS, a three-gene model. Both demonstrated superior predictive performance compared to other glioblastoma signatures in our in-house cohort and five independent Chinese datasets. The SCGPS model was further validated in 109 clinical samples using multiplex immunofluorescence, showing strong consistency with the original CGPS model. Overall, SurvivalML provides a robust platform for the identification and validation of prognostic biomarkers and gene signatures, offering a valuable resource for advancing cancer research and clinical application.
PMID:39864538 | DOI:10.1016/j.canlet.2025.217502
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Nature - Issue - nature.com science feeds
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Tumour vasculature at single-cell resolution
Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07698-1An atlas of tumour vasculature shows that tumour angiogenesis is initiated from venous endothelial cells and extended towards arterial endothelial cells.
Tumour vasculature at single-cell resolution
Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07698-1
An atlas of tumour vasculature shows that tumour angiogenesis is initiated from venous endothelial cells and extended towards arterial endothelial cells.-
Most Recent Articles: Clinical Epigenetics
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Epigenetically regulated gene expression profiles decipher four molecular subtypes with prognostic and therapeutic implications in gastric cancer
Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract which seriously endangers the health of human beings worldwide. Transcriptomic deregulation by epigenetic mechanisms plays ...