Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Trustworthy Blockchain-based Federated Learning for Electronic Health Records: Securing Participant Identity with Decentralized Identifiers and Verifiable Credentials
arXiv:2602.02629v1 Announce Type: cross Abstract: The digitization of healthcare has generated massive volumes of Electronic Health Records (EHRs), offering unprecedented opportunities for training Artificial Intelligence (AI) models. However, stringent privacy regulations such as GDPR and HIPAA have created data silos that prevent centralized training. Federated Learning (FL) has emerged as a promising solution that enables collaborative model training without sharing raw patient data. Despite
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npj Digital Medicine
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Digital intervention <i>mylovia</i> improves sexual functioning in women with sexual dysfunction in randomized controlled trial
npj Digital Medicine, Published online: 03 February 2026; doi:10.1038/s41746-026-02385-zDigital intervention mylovia improves sexual functioning in women with sexual dysfunction in randomized controlled trial
Digital intervention <i>mylovia</i> improves sexual functioning in women with sexual dysfunction in randomized controlled trial
npj Digital Medicine, Published online: 03 February 2026; doi:10.1038/s41746-026-02385-z
Digital intervention mylovia improves sexual functioning in women with sexual dysfunction in randomized controlled trial-
Journal of Medical Internet Research
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Barriers to Digital Health Adoption in Older Adults: Scoping Review Informed by Innovation Resistance Theory
Background: The transformation of digital health technologies has reshaped how healthcare is delivered, particularly in primary care. However, despite the advantages of these innovations, older adults remain among the most resistant users. Traditional technology adoption models may not fully capture the complexity of this reluctance, which is shaped not only by usability challenges but also by emotional, psychological, and identity-related concerns. Innovation Resistance Theory (IRT) offers a co
Barriers to Digital Health Adoption in Older Adults: Scoping Review Informed by Innovation Resistance Theory
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Omics in Gastric
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Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer
Gut. 2026 Jan 30:gutjnl-2025-337247. doi: 10.1136/gutjnl-2025-337247. Online ahead of print.ABSTRACTBACKGROUND: Gastric cancer, with disproportionately higher incidence in East Asia, arises from complex host-microbiome-environment interactions beyond Helicobacter pylori (HP) infection. However, the molecular architecture linking environmental carcinogens, microbial succession and host response remains unclear.OBJECTIVE: To delineate multifactorial aetiologies and clinically actionable subtypes/b
Integrative proteogenomics maps multifactorial aetiology, progression and therapeutic vulnerabilities in gastric cancer
Gut. 2026 Jan 30:gutjnl-2025-337247. doi: 10.1136/gutjnl-2025-337247. Online ahead of print.
ABSTRACT
BACKGROUND: Gastric cancer, with disproportionately higher incidence in East Asia, arises from complex host-microbiome-environment interactions beyond Helicobacter pylori (HP) infection. However, the molecular architecture linking environmental carcinogens, microbial succession and host response remains unclear.
OBJECTIVE: To delineate multifactorial aetiologies and clinically actionable subtypes/biomarkers of gastric cancer through integrative proteogenomic, microbial and environmental exposure profiling.
DESIGN: We established a multiomics atlas of paired tumour, adjacent mucosa tissues and blood from 154 treatment-naïve Taiwanese patients, integrating whole-exome sequencing, RNA-seq, proteome and phosphoproteome profiling with carcinogen signatures, HP status, microbiome composition and refined anatomical mapping. Cell-based functional assays tested carcinogen effects. Microbial subtype was assessed in an independent cohort.
RESULTS: A polycyclic-aromatic-hydrocarbon signature, dibenz[a,h]acridine, emerged as a high-risk exposure promoting invasion, immune suppression and poor survival, significantly exceeding nitrosamine-linked risk in this cohort. Multilayer integration defined three initiation ecologies: HP-driven inflammatory, non-HP microbiome-enriched immune-silent and HP-free microbially depleted states. Among HP-negative tumours, a Streptococcus-enriched subtype associated with tight-junction (CLDN18.2/ZO-1/OCLN) disruption and epithelial-mesenchymal transition, whereas a subset of clinically aggressive cases retained CLDN18.2-high epithelial-stable subtype for therapeutic accessibility. An independent cohort revealed gastric juice-derived Streptococcus anginosus abundance inversely correlated with tight-junction proteins. Anatomical mapping reveals location-specific, sex-specific, subtype-specific oncogenic networks and kinase activity, including CDK4 activation in clinical biomarker-negative tumours. Decision-tree models combining exposure and proteome-immune states refined recurrence and survival prediction beyond stage.
CONCLUSION: This proteogenomic framework defines exposure-informed and microbiome-informed gastric cancer subtypes, providing a molecular schema for patient stratification, prevention and actionable therapeutic vulnerabilities.
PMID:41617485 | DOI:10.1136/gutjnl-2025-337247
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Pulmonary nodule
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Liquid biopsy biomarkers for accurate detection of malignant pulmonary nodules: a meta-analytic approach
Discov Oncol. 2026 Jan 29;17(1):178. doi: 10.1007/s12672-025-03646-1.ABSTRACTPulmonary nodules are a common radiological finding that can be classified as either benign or Malignant, with significant clinical implications. The early detection of malignant nodules is critically important for improving the prognosis of lung cancer, which remains the leading cause of cancer-related mortality worldwide. Traditional imaging techniques have Limitations in accurately classifying pulmonary nodules. Liqu
Liquid biopsy biomarkers for accurate detection of malignant pulmonary nodules: a meta-analytic approach
Discov Oncol. 2026 Jan 29;17(1):178. doi: 10.1007/s12672-025-03646-1.
ABSTRACT
Pulmonary nodules are a common radiological finding that can be classified as either benign or Malignant, with significant clinical implications. The early detection of malignant nodules is critically important for improving the prognosis of lung cancer, which remains the leading cause of cancer-related mortality worldwide. Traditional imaging techniques have Limitations in accurately classifying pulmonary nodules. Liquid biopsy, a minimally invasive method that evaluates circulating components in the Blood, presents promising diagnostic potential in this context. This study aims to evaluate the diagnostic capacity of multiple liquid biopsy biomarkers for early and accurate differentiation between benign and Malignant pulmonary nodules. Accordingly, we conducted a comprehensive study involving a meta-analysis, selecting 16 eligible studies that utilised liquid biopsy to assess various circulating biomarkers in the diagnostic yield. The most significant results were linked to circulating free DNA (cfDNA). However, other components, including circulating tumour cells (CTCs), microRNAs/pfeRNAs, extracellular vesicles (EVs), serological markers, and imaging techniques, also provided valuable information. Similarly, integrating multi-omics data with machine learning models has been shown to enhance the ability to differentiate between benign and malignant pulmonary nodules, thereby supporting early diagnosis and improved management for patients with lung cancer.
PMID:41612093 | PMC:PMC12855667 | DOI:10.1007/s12672-025-03646-1
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Journal of Medical Internet Research
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Products, Performance, and Technological Development of Ambulatory Oxygen Therapy Devices: Scoping Review
Background: Ambulatory oxygen therapy is prescribed for patients with chronic lung diseases who experience exertional hypoxemia. However, available devices may not adequately meet user requirements, and their performance characteristics are heterogeneous. Objective: This study aims to identify devices available for delivery of ambulatory oxygen therapy, the technologies that they use to generate oxygen, the performance characteristics of each device, and the development status. Methods: We used
Products, Performance, and Technological Development of Ambulatory Oxygen Therapy Devices: Scoping Review
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InfoQ

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OpenAI and Anthropic Introduce Healthcare-Focused AI Platforms
OpenAI and Anthropic have announced new healthcare-oriented AI offerings that extend their models beyond general conversational use and into regulated clinical and life sciences environments. Both releases emphasize technical integration, interoperability, and governance, reflecting a shift toward AI systems designed to operate directly within existing healthcare infrastructure. By Robert Krzaczyński
OpenAI and Anthropic Introduce Healthcare-Focused AI Platforms
OpenAI and Anthropic have announced new healthcare-oriented AI offerings that extend their models beyond general conversational use and into regulated clinical and life sciences environments. Both releases emphasize technical integration, interoperability, and governance, reflecting a shift toward AI systems designed to operate directly within existing healthcare infrastructure.
By Robert Krzaczyński-
npj Digital Medicine
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Publisher Correction: Best practice recommendations and considerations for designing and electronically implementing event-driven diaries in clinical trials
npj Digital Medicine, Published online: 27 January 2026; doi:10.1038/s41746-026-02396-wPublisher Correction: Best practice recommendations and considerations for designing and electronically implementing event-driven diaries in clinical trials
Publisher Correction: Best practice recommendations and considerations for designing and electronically implementing event-driven diaries in clinical trials
npj Digital Medicine, Published online: 27 January 2026; doi:10.1038/s41746-026-02396-w
Publisher Correction: Best practice recommendations and considerations for designing and electronically implementing event-driven diaries in clinical trials-
cs.AI, q-bio.NC updates on arXiv.org
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High-Fidelity Longitudinal Patient Simulation Using Real-World Data
arXiv:2601.17310v1 Announce Type: new Abstract: Simulation is a powerful tool for exploring uncertainty. Its potential in clinical medicine is transformative and includes personalized treatment planning and virtual clinical trials. However, simulating patient trajectories is challenging because of complex biological and sociocultural influences. Here, we show that real-world clinical records can be leveraged to empirically model patient timelines. We developed a generative simulator model that
High-Fidelity Longitudinal Patient Simulation Using Real-World Data
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cs.AI, q-bio.NC updates on arXiv.org
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Decentralized Multi-Agent Swarms for Autonomous Grid Security in Industrial IoT: A Consensus-based Approach
arXiv:2601.17303v1 Announce Type: cross Abstract: As Industrial Internet of Things (IIoT) environments expand to include tens of thousands of connected devices. The centralization of security monitoring architectures creates serious latency issues that savvy attackers can exploit to compromise an entire manufacturing ecosystem. This paper outlines a new, decentralized multi-agent swarm (DMAS) architecture that includes autonomous artificial intelligence (AI) agents at each edge gateway, functio
Decentralized Multi-Agent Swarms for Autonomous Grid Security in Industrial IoT: A Consensus-based Approach
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cs.AI, q-bio.NC updates on arXiv.org
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Coronary Artery Segmentation and Vessel-Type Classification in X-Ray Angiography
arXiv:2601.17429v1 Announce Type: cross Abstract: X-ray coronary angiography (XCA) is the clinical reference standard for assessing coronary artery disease, yet quantitative analysis is limited by the difficulty of robust vessel segmentation in routine data. Low contrast, motion, foreshortening, overlap, and catheter confounding degrade segmentation and contribute to domain shift across centers. Reliable segmentation, together with vessel-type labeling, enables vessel-specific coronary analytic
Coronary Artery Segmentation and Vessel-Type Classification in X-Ray Angiography
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cs.AI, q-bio.NC updates on arXiv.org
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"Rebuilding" Statistics in the Age of AI: A Town Hall Discussion on Culture, Infrastructure, and Training
arXiv:2601.17510v1 Announce Type: cross Abstract: This article presents the full, original record of the 2024 Joint Statistical Meetings (JSM) town hall, "Statistics in the Age of AI," which convened leading statisticians to discuss how the field is evolving in response to advances in artificial intelligence, foundation models, large-scale empirical modeling, and data-intensive infrastructures. The town hall was structured around open panel discussion and extensive audience Q&A, with the ai
"Rebuilding" Statistics in the Age of AI: A Town Hall Discussion on Culture, Infrastructure, and Training
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cs.AI, q-bio.NC updates on arXiv.org
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GenAI-Net: A Generative AI Framework for Automated Biomolecular Network Design
arXiv:2601.17582v1 Announce Type: cross Abstract: Biomolecular networks underpin emerging technologies in synthetic biology-from robust biomanufacturing and metabolic engineering to smart therapeutics and cell-based diagnostics-and also provide a mechanistic language for understanding complex dynamics in natural and ecological systems. Yet designing chemical reaction networks (CRNs) that implement a desired dynamical function remains largely manual: while a proposed network can be checked by si
GenAI-Net: A Generative AI Framework for Automated Biomolecular Network Design
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cs.AI, q-bio.NC updates on arXiv.org
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The Limits of AI Data Transparency Policy: Three Disclosure Fallacies
arXiv:2601.18127v1 Announce Type: cross Abstract: Data transparency has emerged as a rallying cry for addressing concerns about AI: data quality, privacy, and copyright chief among them. Yet while these calls are crucial for accountability, current transparency policies often fall short of their intended aims. Similar to nutrition facts for food, policies aimed at nutrition facts for AI currently suffer from a limited consideration of research on effective disclosures. We offer an institutional
The Limits of AI Data Transparency Policy: Three Disclosure Fallacies
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cs.AI, q-bio.NC updates on arXiv.org
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Computational Phenomenology of Borderline Personality Disorder: A Comparative Evaluation of LLM-Simulated Expert Personas and Human Clinical Experts
arXiv:2508.19008v2 Announce Type: replace Abstract: Building on a human-led thematic analysis of life-story interviews with inpatients with Borderline Personality Disorder, this study examines the capacity of large language models (OpenAI's GPT, Google's Gemini, and Anthropic's Claude) to support qualitative clinical analysis. The models were evaluated through a mixed procedure. Study A involved blinded and non-blinded expert judges in phenomenology and clinical psychology. Assessments included
Computational Phenomenology of Borderline Personality Disorder: A Comparative Evaluation of LLM-Simulated Expert Personas and Human Clinical Experts
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cs.AI, q-bio.NC updates on arXiv.org
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MEDIC: Comprehensive Evaluation of Leading Indicators for LLM Safety and Utility in Clinical Applications
arXiv:2409.07314v2 Announce Type: replace-cross Abstract: While Large Language Models (LLMs) achieve superhuman performance on standardized medical licensing exams, these static benchmarks have become saturated and increasingly disconnected from the functional requirements of clinical workflows. To bridge the gap between theoretical capability and verified utility, we introduce MEDIC, a comprehensive evaluation framework establishing leading indicators across various clinical dimensions. Beyond
MEDIC: Comprehensive Evaluation of Leading Indicators for LLM Safety and Utility in Clinical Applications
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cs.AI, q-bio.NC updates on arXiv.org
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Multimodal Cancer Modeling in the Age of Foundation Model Embeddings
arXiv:2505.07683v4 Announce Type: replace-cross Abstract: The Cancer Genome Atlas (TCGA) has enabled novel discoveries and served as a large-scale reference dataset in cancer through its harmonized genomics, clinical, and imaging data. Numerous prior studies have developed bespoke deep learning models over TCGA for tasks such as cancer survival prediction. A modern paradigm in biomedical deep learning is the development of foundation models (FMs) to derive feature embeddings agnostic to a speci
Multimodal Cancer Modeling in the Age of Foundation Model Embeddings
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Journal of Medical Internet Research
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Feasibility, Acceptability, and Perspectives Regarding the Use of Activity Tracking Wearable Devices Among Home Health Aides: Mixed Methods Study
Background: Home health aides and attendants (HHAs) provide in-home care to the growing population of older adults who want to age in place. Despite their vital role in patient care, HHAs are an underserved and vulnerable population of health care professionals who often experience poor health themselves. Activity tracking devices offer a promising way to improve HHAs’ health-related awareness and promote health behavior change, particularly regarding physical activity and sleep quality, 2 areas
Feasibility, Acceptability, and Perspectives Regarding the Use of Activity Tracking Wearable Devices Among Home Health Aides: Mixed Methods Study
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cs.AI, q-bio.NC updates on arXiv.org
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PyHealth 2.0: A Comprehensive Open-Source Toolkit for Accessible and Reproducible Clinical Deep Learning
arXiv:2601.16414v1 Announce Type: cross Abstract: Difficulty replicating baselines, high computational costs, and required domain expertise create persistent barriers to clinical AI research. To address these challenges, we introduce PyHealth 2.0, an enhanced clinical deep learning toolkit that enables predictive modeling in as few as 7 lines of code. PyHealth 2.0 offers three key contributions: (1) a comprehensive toolkit addressing reproducibility and compatibility challenges by unifying 15+
PyHealth 2.0: A Comprehensive Open-Source Toolkit for Accessible and Reproducible Clinical Deep Learning
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cs.AI, q-bio.NC updates on arXiv.org
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The Responsibility Vacuum: Organizational Failure in Scaled Agent Systems
arXiv:2601.15059v1 Announce Type: new Abstract: Modern CI/CD pipelines integrating agent-generated code exhibit a structural failure in responsibility attribution. Decisions are executed through formally correct approval processes, yet no entity possesses both the authority to approve those decisions and the epistemic capacity to meaningfully understand their basis. We define this condition as responsibility vacuum: a state in which decisions occur, but responsibility cannot be attributed bec