npj Digital Medicine
AI-driven virtual cell models in preclinical research: technical pathways, validation mechanisms, and clinical translation potential Chunyu Ma · Han Zhang · Yiwei Rao · Xinyu Jiang · Boheng Liu · Zhikang Sun · Zhenyu Song · Yuan Gao · Yuhao Cui · Xinyu Liu · Zedong Li
npj Digital Medicine, Published online: 11 December 2025; doi:10.1038/s41746-025-02198-6AI-driven virtual cell models in preclinical research: technical pathways, validation mechanisms, and clinical translation potential
11 December 2025 at 08:00

AI-driven virtual cell models in preclinical research: technical pathways, validation mechanisms, and clinical translation potential

By: Chunyu Ma · Han Zhang · Yiwei Rao · Xinyu Jiang · Boheng Liu · Zhikang Sun · Zhenyu Song · Yuan Gao · Yuhao Cui · Xinyu Liu · Zedong Li

11 December 2025 at 08:00

npj Digital Medicine, Published online: 11 December 2025; doi:10.1038/s41746-025-02198-6

Cell
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors Xing Kang · Xinran Li · Jiaqi Zhou · Yang Zhang · Lingyu Qiu · Congcong Tian · Zhiwen Deng · Xiaoyan Liang · Ziwei Zhang · Songlin Du · Suili Hu · Nan Wang · Zhen Yue · Yajing Xu · Yuan Gao · Junbiao Dai · Zhiquan Wang · Chuanhe Yu · Jinyi Chen · Yuchun Wu · Liangming Chen · Yuan Yao · Sitong Yao · Xinran Yang · Lixia Yan · Qing Wen · Olivia M. Depies · Kuiming Chan · Xiaohuan Liang · Gang Li · Zhike Zi · Xiangyu Liu · Haiyun Gan
This study demonstrates that extrachromosomal DNA (ecDNA) replication induces DNA double-strand breaks and activates the DNA damage response (DDR). The DDR pathways, such as alt-NHEJ, are critical for ecDNA maintenance in tumor cells. Mechanistic insights into ecDNA replication and maintenance unveil a therapeutic approach for treating tumors harboring ecDNA.
28 April 2025 at 08:00

Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors

Cell

By: Xing Kang · Xinran Li · Jiaqi Zhou · Yang Zhang · Lingyu Qiu · Congcong Tian · Zhiwen Deng · Xiaoyan Liang · Ziwei Zhang · Songlin Du · Suili Hu · Nan Wang · Zhen Yue · Yajing Xu · Yuan Gao · Junbiao Dai · Zhiquan Wang · Chuanhe Yu · Jinyi Chen · Yuchun Wu · Liangming Chen · Yuan Yao · Sitong Yao · Xinran Yang · Lixia Yan · Qing Wen · Olivia M. Depies · Kuiming Chan · Xiaohuan Liang · Gang Li · Zhike Zi · Xiangyu Liu · Haiyun Gan

28 April 2025 at 08:00

This study demonstrates that extrachromosomal DNA (ecDNA) replication induces DNA double-strand breaks and activates the DNA damage response (DDR). The DDR pathways, such as alt-NHEJ, are critical for ecDNA maintenance in tumor cells. Mechanistic insights into ecDNA replication and maintenance unveil a therapeutic approach for treating tumors harboring ecDNA.

Cell
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations Jason J. Liu · Beatrice Borsari · Yunyang Li · Susanna X. Liu · Yuan Gao · Xin Xin · Shaoke Lou · Matthew Jensen · Diego Garrido-Martín · Terril L. Verplaetse · Garrett Ash · Jing Zhang · Matthew J. Girgenti · Walter Roberts · Mark Gerstein
Complex disorders require precise strategies for their characterization. AI-based digital phenotypes from biosensors can be used to predict psychiatric disorders and identify GWAS loci.
19 December 2024 at 08:00

Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations

Cell

By: Jason J. Liu · Beatrice Borsari · Yunyang Li · Susanna X. Liu · Yuan Gao · Xin Xin · Shaoke Lou · Matthew Jensen · Diego Garrido-Martín · Terril L. Verplaetse · Garrett Ash · Jing Zhang · Matthew J. Girgenti · Walter Roberts · Mark Gerstein

19 December 2024 at 08:00

Complex disorders require precise strategies for their characterization. AI-based digital phenotypes from biosensors can be used to predict psychiatric disorders and identify GWAS loci.

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