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Received — 25 July 2025 ⏭ Favourites

(Multiomics OR Omics) AND (Pancreatic)
PIVOT: an open-source tool for multi-omic spatial data registration André Forjaz · Valentina Matos Romero · Ian Reucroft · Margaret Eminizer · Donald Kramer · Daniela Higuera · Hengameh Mojdeganlou · Paola A Guerrero · Jimin Min · Meredith Wetzel · Dmitrijs Lvovs · Alens Valentin · Sarah M Shin · Xuan Yuan · Rosalie C Sears · Koei Chin · Anirban Maitra · Elana J Fertig · Won Jin Ho · Luciane T Kagohara · Laura D Wood · Denis Wirtz · Dimitrios N Sidiropoulos · Ashley L Kiemen
bioRxiv [Preprint]. 2025 Jun 8:2025.06.08.658506. doi: 10.1101/2025.06.08.658506.ABSTRACTAdvances in spatial profiling have resulted in the generation of multi-omic atlases that span biological scales. In general, multiple workflows are required for image registration, coordinate registration, and spot deconvolution to integrate modalities. To improve the throughput of registration of multi-omic cohorts, we introduce PIVOT, a user-friendly and open-source interface for streamlined nonlinear regi
15 July 2025 at 18:00

PIVOT: an open-source tool for multi-omic spatial data registration

By: André Forjaz · Valentina Matos Romero · Ian Reucroft · Margaret Eminizer · Donald Kramer · Daniela Higuera · Hengameh Mojdeganlou · Paola A Guerrero · Jimin Min · Meredith Wetzel · Dmitrijs Lvovs · Alens Valentin · Sarah M Shin · Xuan Yuan · Rosalie C Sears · Koei Chin · Anirban Maitra · Elana J Fertig · Won Jin Ho · Luciane T Kagohara · Laura D Wood · Denis Wirtz · Dimitrios N Sidiropoulos · Ashley L Kiemen

15 July 2025 at 18:00

bioRxiv [Preprint]. 2025 Jun 8:2025.06.08.658506. doi: 10.1101/2025.06.08.658506.

ABSTRACT

Advances in spatial profiling have resulted in the generation of multi-omic atlases that span biological scales. In general, multiple workflows are required for image registration, coordinate registration, and spot deconvolution to integrate modalities. To improve the throughput of registration of multi-omic cohorts, we introduce PIVOT, a user-friendly and open-source interface for streamlined nonlinear registration. We demonstrate PIVOT's strengths through registration of three multi-omic datasets, and show comparison of its performance to existing workflows.

PMID:40661390 | PMC:PMC12259011 | DOI:10.1101/2025.06.08.658506

Cell
Personalized molecular signatures of insulin resistance and type 2 diabetes Jeppe Kjærgaard · Ben Stocks · John Henderson · Jordana B. Freemantle · David Rizo-Roca · Michele Puglia · Maria Madrazo Montoya · Daniel Andersson · Jesper Bäckdahl · Daniel Eriksson-Hogling · Jacob V. Stidsen · Michael Wierer · Simon Rasmussen · Kei Sakamoto · Kurt Højlund · Mikael Rydén · Juleen R. Zierath · Anna Krook · Atul S. Deshmukh
Muscle samples from over 120 people were analyzed to identify molecular patterns linked to insulin resistance, a key feature of type 2 diabetes. The findings reveal new insights that could help tailor more personalized and effective treatments for the disease.
27 May 2025 at 08:00

Personalized molecular signatures of insulin resistance and type 2 diabetes

Cell

By: Jeppe Kjærgaard · Ben Stocks · John Henderson · Jordana B. Freemantle · David Rizo-Roca · Michele Puglia · Maria Madrazo Montoya · Daniel Andersson · Jesper Bäckdahl · Daniel Eriksson-Hogling · Jacob V. Stidsen · Michael Wierer · Simon Rasmussen · Kei Sakamoto · Kurt Højlund · Mikael Rydén · Juleen R. Zierath · Anna Krook · Atul S. Deshmukh

27 May 2025 at 08:00

Muscle samples from over 120 people were analyzed to identify molecular patterns linked to insulin resistance, a key feature of type 2 diabetes. The findings reveal new insights that could help tailor more personalized and effective treatments for the disease.