arXiv:2511.01935v1 Announce Type: cross Abstract: The determination of sample size in qualitative research has traditionally relied on the subjective and often ambiguous principle of data saturation, which can lead to inconsistencies and threaten methodological rigor. This study introduces a new, systematic model based on machine learning (ML) to make this process more objective. Utilizing a dataset derived from five fundamental qualitative research approaches - namely, Case Study, Grounded Theory, Phenomenology, Narrative Research, and Ethnographic Research - we developed an ensemble learning model. Ten critical parameters, including research scope, information power, and researcher competence, were evaluated using an ordinal scale and used as input features. After thorough preprocessing and outlier removal, multiple ML algorithms were trained and compared. The K-Nearest Neighbors (KNN), Gradient Boosting (GB), Random Forest (RF), XGBoost, and Decision Tree (DT) algorithms showed the highest explanatory power (Test R2 ~ 0.85), effectively modeling the complex, non-linear relationships involved in qualitative sampling decisions. Feature importance analysis confirmed the vital roles of research design type and information power, providing quantitative validation of key theoretical assumptions in qualitative methodology. The study concludes by proposing a conceptual framework for a web-based computational application designed to serve as a decision support system for qualitative researchers, journal reviewers, and thesis advisors. This model represents a significant step toward standardizing sample size justification, enhancing transparency, and strengthening the epistemological foundation of qualitative inquiry through evidence-based, systematic decision-making.

arXiv:2511.02531v1 Announce Type: cross Abstract: Healthcare artificial intelligence systems routinely fail when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in historical data. This brittleness stems, in part, from learning statistical associations rather than causal mechanisms. Causal graph neural networks address this triple crisis of distribution shift, discrimination, and inscrutability by combining graph-based representations of biomedical data with causal inference principles to learn invariant mechanisms rather than spurious correlations. This Review examines methodological foundations spanning structural causal models, disentangled causal representation learning, and techniques for interventional prediction and counterfactual reasoning on graphs. We analyse applications demonstrating clinical value across psychiatric diagnosis through brain network analysis, cancer subtyping via multi-omics causal integration, continuous physiological monitoring with mechanistic interpretation, and drug recommendation correcting prescription bias. These advances establish foundations for patient-specific Causal Digital Twins, enabling in silico clinical experimentation, with integration of large language models for hypothesis generation and causal graph neural networks for mechanistic validation. Substantial barriers remain, including computational requirements precluding real-time deployment, validation challenges demanding multi-modal evidence triangulation beyond cross-validation, and risks of causal-washing where methods employ causal terminology without rigorous evidentiary support. We propose tiered frameworks distinguishing causally-inspired architectures from causally-validated discoveries and identify critical research priorities making causal rather than purely associational claims.

arXiv:2511.02752v1 Announce Type: cross Abstract: Artificial intelligence (AI) is diffusing globally at unprecedented speed, but adoption remains uneven. Frontier Large Language Models (LLMs) are known to perform poorly on low-resource languages due to data scarcity. We hypothesize that this performance deficit reduces the utility of AI, thereby slowing adoption in Low-Resource Language Countries (LRLCs). To test this, we use a weighted regression model to isolate the language effect from socioeconomic and demographic factors, finding that LRLCs have a share of AI users that is approximately 20% lower relative to their baseline. These results indicate that linguistic accessibility is a significant, independent barrier to equitable AI diffusion.

arXiv:2511.02805v1 Announce Type: cross Abstract: Typical search agents concatenate the entire interaction history into the LLM context, preserving information integrity but producing long, noisy contexts, resulting in high computation and memory costs. In contrast, using only the current turn avoids this overhead but discards essential information. This trade-off limits the scalability of search agents. To address this challenge, we propose MemSearcher, an agent workflow that iteratively maintains a compact memory and combines the current turn with it. At each turn, MemSearcher fuses the user's question with the memory to generate reasoning traces, perform search actions, and update memory to retain only information essential for solving the task. This design stabilizes context length across multi-turn interactions, improving efficiency without sacrificing accuracy. To optimize this workflow, we introduce multi-context GRPO, an end-to-end RL framework that jointly optimize reasoning, search strategies, and memory management of MemSearcher Agents. Specifically, multi-context GRPO samples groups of trajectories under different contexts and propagates trajectory-level advantages across all conversations within them. Trained on the same dataset as Search-R1, MemSearcher achieves significant improvements over strong baselines on seven public benchmarks: +11% on Qwen2.5-3B-Instruct and +12% on Qwen2.5-7B-Instruct relative average gains. Notably, the 3B-based MemSearcher even outperforms 7B-based baselines, demonstrating that striking a balance between information integrity and efficiency yields both higher accuracy and lower computational overhead. The code and models will be publicly available at https://github.com/icip-cas/MemSearcher

arXiv:2510.09801v2 Announce Type: replace Abstract: LLM-powered agents are both a promising new technology and a source of complexity, where choices about models, tools, and prompting can affect their usefulness. While numerous benchmarks measure agent accuracy across domains, they mostly assume full automation, failing to represent the collaborative nature of real-world use cases. In this paper, we make two major steps towards the rigorous assessment of human-agent interactions. First, we propose PULSE, a framework for more efficient human-centric evaluation of agent designs, which comprises collecting user feedback, training an ML model to predict user satisfaction, and computing results by combining human satisfaction ratings with model-generated pseudo-labels. Second, we deploy the framework on a large-scale web platform built around the open-source software agent OpenHands, collecting in-the-wild usage data across over 15k users. We conduct case studies around how three agent design decisions -- choice of LLM backbone, planning strategy, and memory mechanisms -- impact developer satisfaction rates, yielding practical insights for software agent design. We also show how our framework can lead to more robust conclusions about agent design, reducing confidence intervals by 40% compared to a standard A/B test. Finally, we find substantial discrepancies between in-the-wild results and benchmark performance (e.g., the anti-correlation between results comparing claude-sonnet-4 and gpt-5), underscoring the limitations of benchmark-driven evaluation. Our findings provide guidance for evaluations of LLM agents with humans and identify opportunities for better agent designs.

arXiv:2504.04365v5 Announce Type: replace-cross Abstract: The performance of large language models (LLMs) depends on how they are prompted, with choices spanning both the high-level prompting pattern (e.g., Zero-Shot, CoT, ReAct, ReWOO) and the specific prompt content (instructions and few-shot demonstrations). Manually tuning this combination is tedious, error-prone, and specific to a given LLM and task. Therefore, this paper proposes AutoPDL, an automated approach to discovering good LLM agent configurations. Our approach frames this as a structured AutoML problem over a combinatorial space of agentic and non-agentic prompting patterns and demonstrations, using successive halving to efficiently navigate this space. We introduce a library implementing common prompting patterns using the PDL prompt programming language. AutoPDL solutions are human-readable, editable, and executable PDL programs that use this library. This approach also enables source-to-source optimization, allowing human-in-the-loop refinement and reuse. Evaluations across three tasks and seven LLMs (ranging from 3B to 70B parameters) show consistent accuracy gains ($9.21\pm15.46$ percentage points), up to 67.5pp, and reveal that selected prompting strategies vary across models and tasks.

Nature, Published online: 05 November 2025; doi:10.1038/d41586-025-03540-4

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