arXiv:2511.09247v1 Announce Type: new Abstract: Clinical time series derived from electronic health records (EHRs) are inherently irregular, with asynchronous sampling, missing values, and heterogeneous feature dynamics. While numerical laboratory measurements are highly informative, existing embedding strategies usually combine feature identity and value embeddings through additive operations, which constrains their ability to capture value-dependent feature interactions. We propose MedFuse, a framework for irregular clinical time series centered on the MuFuse (Multiplicative Embedding Fusion) module. MuFuse fuses value and feature embeddings through multiplicative modulation, preserving feature-specific information while modeling higher-order dependencies across features. Experiments on three real-world datasets covering both intensive and chronic care show that MedFuse consistently outperforms state-of-the-art baselines on key predictive tasks. Analysis of the learned representations further demonstrates that multiplicative fusion enhances expressiveness and supports cross-dataset pretraining. These results establish MedFuse as a generalizable approach for modeling irregular clinical time series.

arXiv:2511.08637v1 Announce Type: cross Abstract: The internet has become the main source of data to train modern text-to-image or vision-language models, yet it is increasingly unclear whether web-scale data collection practices for training AI systems adequately respect data owners' wishes. Ignoring the owner's indication of consent around data usage not only raises ethical concerns but also has recently been elevated into lawsuits around copyright infringement cases. In this work, we aim to reveal information about data owners' consent to AI scraping and training, and study how it's expressed in DataComp, a popular dataset of 12.8 billion text-image pairs. We examine both the sample-level information, including the copyright notice, watermarking, and metadata, and the web-domain-level information, such as a site's Terms of Service (ToS) and Robots Exclusion Protocol. We estimate at least 122M of samples exhibit some indication of copyright notice in CommonPool, and find that 60\% of the samples in the top 50 domains come from websites with ToS that prohibit scraping. Furthermore, we estimate 9-13\% with 95\% confidence interval of samples from CommonPool to contain watermarks, where existing watermark detection methods fail to capture them in high fidelity. Our holistic methods and findings show that data owners rely on various channels to convey data consent, of which current AI data collection pipelines do not entirely respect. These findings highlight the limitations of the current dataset curation/release practice and the need for a unified data consent framework taking AI purposes into consideration.

arXiv:2511.08721v1 Announce Type: cross Abstract: In behavioral sciences, experiments such as the ultimatum game are conducted to assess preferences for fairness or self-interest of study participants. In the dictator game, a simplified version of the ultimatum game where only one of two players makes a single decision, the dictator unilaterally decides how to split a fixed sum of money between themselves and the other player. Although recent studies have explored behavioral patterns of AI agents based on Large Language Models (LLMs) instructed to adopt different personas, we question the robustness of these results. In particular, many of these studies overlook the role of the system prompt - the underlying instructions that shape the model's behavior - and do not account for how sensitive results can be to slight changes in prompts. However, a robust baseline is essential when studying highly complex behavioral aspects of LLMs. To overcome previous limitations, we propose the LLM agent behavior study (LLM-ABS) framework to (i) explore how different system prompts influence model behavior, (ii) get more reliable insights into agent preferences by using neutral prompt variations, and (iii) analyze linguistic features in responses to open-ended instructions by LLM agents to better understand the reasoning behind their behavior. We found that agents often exhibit a strong preference for fairness, as well as a significant impact of the system prompt on their behavior. From a linguistic perspective, we identify that models express their responses differently. Although prompt sensitivity remains a persistent challenge, our proposed framework demonstrates a robust foundation for LLM agent behavior studies. Our code artifacts are available at https://github.com/andreaseinwiller/LLM-ABS.

arXiv:2511.09294v1 Announce Type: cross Abstract: Federated learning (FL) enables privacy-preserving collaborative model training but remains vulnerable to adversarial behaviors that compromise model utility or fairness across sensitive groups. While extensive studies have examined attacks targeting either objective, strategies that simultaneously degrade both utility and fairness remain largely unexplored. To bridge this gap, we introduce the Dual-Facet Attack (DFA), a novel threat model that concurrently undermines predictive accuracy and group fairness. Two variants, Synchronous DFA (S-DFA) and Split DFA (Sp-DFA), are further proposed to capture distinct real-world collusion scenarios. Experimental results show that existing robust FL defenses, including hybrid aggregation schemes, fail to resist DFAs effectively. To counter these threats, we propose GuardFed, a self-adaptive defense framework that maintains a fairness-aware reference model using a small amount of clean server data augmented with synthetic samples. In each training round, GuardFed computes a dual-perspective trust score for every client by jointly evaluating its utility deviation and fairness degradation, thereby enabling selective aggregation of trustworthy updates. Extensive experiments on real-world datasets demonstrate that GuardFed consistently preserves both accuracy and fairness under diverse non-IID and adversarial conditions, achieving state-of-the-art performance compared with existing robust FL methods.

arXiv:2510.10675v2 Announce Type: replace Abstract: Generative Agentic AI systems are emerging as a powerful paradigm for automating complex, multi-step tasks. However, many existing frameworks for building these systems introduce significant complexity, a steep learning curve, and substantial boilerplate code, hindering rapid prototyping and deployment. This paper introduces simpliflow, a lightweight, open-source Python framework designed to address these challenges. simpliflow enables the rapid development and orchestration of linear, deterministic agentic workflows through a declarative, JSON-based configuration. Its modular architecture decouples agent management, workflow execution, and post-processing, promoting ease of use and extensibility. By integrating with LiteLLM, it supports over 100 Large Language Models (LLMs) out-of-the-box. We present the architecture, operational flow, and core features of simpliflow, demonstrating its utility through diverse use cases ranging from software development simulation to real-time system interaction. A comparative analysis with prominent frameworks like LangChain and AutoGen highlights simpliflow's unique position as a tool optimized for simplicity, control, and speed in deterministic workflow environments.

arXiv:2410.15281v4 Announce Type: replace-cross Abstract: With the broader adoption and highly successful development of Large Language Models (LLMs), there has been growing interest and demand for applying LLMs to autonomous driving technology. Driven by their natural language understanding and reasoning capabilities, LLMs have the potential to enhance various aspects of autonomous driving systems, from perception and scene understanding to interactive decision-making. In this paper, we first introduce the novel concept of designing Large Language Models for Autonomous Driving (LLM4AD), followed by a review of existing LLM4AD studies. Then, we propose a comprehensive benchmark for evaluating the instruction-following and reasoning abilities of LLM4AD systems, which includes LaMPilot-Bench, CARLA Leaderboard 1.0 Benchmark in simulation and NuPlanQA for multi-view visual question answering. Furthermore, we conduct extensive real-world experiments on autonomous vehicle platforms, examining both on-cloud and on-edge LLM deployment for personalized decision-making and motion control. Next, we explore the future trends of integrating language diffusion models into autonomous driving, exemplified by the proposed ViLaD (Vision-Language Diffusion) framework. Finally, we discuss the main challenges of LLM4AD, including latency, deployment, security and privacy, safety, trust and transparency, and personalization.

arXiv:2410.21348v3 Announce Type: replace-cross Abstract: With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark datasets employed in medical LLM tasks. These datasets span multiple modalities including text, image, and multimodal benchmarks, focusing on different aspects of medical knowledge such as electronic health records (EHRs), doctor-patient dialogues, medical question-answering, and medical image captioning. The survey categorizes the datasets by modality, discussing their significance, data structure, and impact on the development of LLMs for clinical tasks such as diagnosis, report generation, and predictive decision support. Key benchmarks include MIMIC-III, MIMIC-IV, BioASQ, PubMedQA, and CheXpert, which have facilitated advancements in tasks like medical report generation, clinical summarization, and synthetic data generation. The paper summarizes the challenges and opportunities in leveraging these benchmarks for advancing multimodal medical intelligence, emphasizing the need for datasets with a greater degree of language diversity, structured omics data, and innovative approaches to synthesis. This work also provides a foundation for future research in the application of LLMs in medicine, contributing to the evolving field of medical artificial intelligence.

arXiv:2508.01159v2 Announce Type: replace-cross Abstract: This study evaluates the capacity of large language models (LLMs) to generate structured clinical consultation templates for electronic consultation. Using 145 expert-crafted templates developed and routinely used by Stanford's eConsult team, we assess frontier models -- including o3, GPT-4o, Kimi K2, Claude 4 Sonnet, Llama 3 70B, and Gemini 2.5 Pro -- for their ability to produce clinically coherent, concise, and prioritized clinical question schemas. Through a multi-agent pipeline combining prompt optimization, semantic autograding, and prioritization analysis, we show that while models like o3 achieve high comprehensiveness (up to 92.2\%), they consistently generate excessively long templates and fail to correctly prioritize the most clinically important questions under length constraints. Performance varies across specialties, with significant degradation in narrative-driven fields such as psychiatry and pain medicine. Our findings demonstrate that LLMs can enhance structured clinical information exchange between physicians, while highlighting the need for more robust evaluation methods that capture a model's ability to prioritize clinically salient information within the time constraints of real-world physician communication.

Stereo-seq V2 facilitates single-cell-resolution spatial RNA mapping in FFPE samples through random primer capture, uncovering ncRNAs, host-pathogen transcriptome profiling, and spatial immune repertoires in situ.

Background: In recent years, large language models (LLMs) have experienced rapid development. LLM-based virtual patients have begun to gain attention, offering new opportunities for simulations in medical education. Objective: This study aims to systematically analyze the current applications, research trends, and challenges of LLM-based virtual patients in medical education and to explore potential future directions for development. Methods: This study adheres to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. Five databases (Web of Science Core Collection, PubMed, IEEE Xplore, Embase, and Scopus) were searched from January 1, 2018, to June 24, 2025, to identify studies related to the application of LLM-based virtual patients in medical education. A comprehensive analysis of LLM-based virtual patients from research design to application and evaluation was conducted. Results: A total of 28 studies were included in this scoping review. Analysis revealed that 92.9% (26/28) of the studies were published in the past 2 years, indicating that LLM-based virtual patient research is still in its early stages. The research primarily focuses on medical training and spans a wide range of medical disciplines. When using LLMs, advanced technologies such as social robots, virtual reality, and mixed reality are used to present LLM-based virtual patients. Combining these technologies with various supplementary tools enhances the realism of LLM-based virtual patients and improves user interaction. The evaluation of LLM-based virtual patients mainly emphasizes user experience. However, evaluation methods lack standardization, and only 13% (3/23) of studies used validated tools in assessing LLM-based virtual patients, while only 21.7% (5/23) of studies objectively measured learning outcomes facilitated by LLM-based virtual patients. All included studies expressed a positive attitude toward LLM-based virtual patients; however, they overlook privacy and security considerations in practical applications. Conclusions: LLM-based virtual patients hold significant innovation potential in medical education and are still in the early stages of development. They are primarily applied in medical training and show promise in communication skills training, although they cannot replace real-world interactions. Moreover, the heterogeneity of research designs, the absence of nonverbal cues in interactions, and concerns regarding privacy and security limit their broader implementation. Future research should focus on improving the reliability, realism, safety, and scientific efficacy of LLM-based virtual patients. Trial Registration: Open Science Framework Registries 10.17605/OSF.IO/DMC9Q; https://osf.io/DMC9Q/overview

npj Digital Medicine, Published online: 12 November 2025; doi:10.1038/s41746-025-02013-2

Equipping mathematical models for hospital dynamics using information theory